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[null,null,"Titolo",null,"Glucose-sensing Receptor in Pancreatic Beta-cells / / edited by Itaru Kojima"]
[null,null,"Pubbl/distr/stampa",null,"Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018"]
[null,null,"ISBN",null,"981-13-0002-X"]
[null,null,"Edizione",null,"[1st ed. 2018.]"]
[null,null,"Descrizione fisica",null,"1 online resource (73 pages)"]
[null,null,"Disciplina",null,"573.377"]
[null,null,"Soggetti",null,"Human physiology"]
[{"$nulls":4},"Endocrinology"]
[{"$nulls":4},"Human Physiology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"1 HISTORY OF THE RESEARCH ON THE GLUCOSE RECEPTOR  -- 2 Cell-surface Glucoreceptor Recognizing Anomers of Glucose in Pancreatic b-cells  -- 3 KATP CHANNEL-INDEPENDENT PATHWAY and THE GLUCORECEPTOR  -- 4 Signaling System Activated by the Glucose-sensing Receptor -- 5 The Role of the Glucose-sensing Receptor in Glucose-induced Insulin Secretion in Pancreatic b-cells."]
[null,null,null,"Sommario/riassunto","Since the 1970s, there has been much discussion about the “glucoreceptor” and “substrate site” and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the “glucoreceptor theory.” This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells. The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: “glucoreceptor theory”. Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes. ."]