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[null,"1.","Record Nr.",null,"UNINA9910463507503321"]
[null,null,"Autore",null,"Altman Douglas"]
[null,null,"Titolo",null,"Statistics with confidence : confidence intervals and statistical guidelines / / Douglas Altman"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, : Wiley, 2013"]
[null,null,"ISBN",null,"1-118-70251-4"]
[{"$nulls":4},"1-322-19630-3"]
[{"$nulls":4},"0-7279-1375-1"]
[null,null,"Edizione",null,"[Second edition.]"]
[null,null,"Descrizione fisica",null,"1 online resource (254 pages)"]
[null,null,"Disciplina",null,"362.102"]
[{"$nulls":4},"610.727"]
[null,null,"Soggetti",null,"Analysis of variance"]
[{"$nulls":4},"Confidence intervals"]
[{"$nulls":4},"Statistics as topic -- Methods"]
[{"$nulls":4},"Statistics as Topic"]
[{"$nulls":4},"Confidence Intervals"]
[{"$nulls":4},"Epidemiologic Methods"]
[{"$nulls":4},"Health Care Evaluation Mechanisms"]
[{"$nulls":4},"Mathematics"]
[{"$nulls":4},"Quality of Health Care"]
[{"$nulls":4},"Investigative Techniques"]
[{"$nulls":4},"Natural Science Disciplines"]
[{"$nulls":4},"Public Health"]
[{"$nulls":4},"Health Care Quality, Access, and Evaluation"]
[{"$nulls":4},"Analytical, Diagnostic and Therapeutic Techniques and Equipment"]
[{"$nulls":4},"Environment and Public Health"]
[{"$nulls":4},"Disciplines and Occupations"]
[{"$nulls":4},"Health Care"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,"Nota di contenuto",null,"Cover; Title Page; Contents; Contributors; Source of contents; Introduction; PART I ESTIMATION AND CONFIDENCE INTERVALS; 1 Estimating with confidence; 2 Confidence intervals in practice; 3 "]
[{"$nulls":4},"Confidence intervals rather than P values; 4 Means and their differences; 5 Medians and their differences; 6 Proportions and their differences; 7 Epidemiological studies; 8 Regression and correlation; 9 Time to event studies; 10 Diagnostic tests; 11 Clinical trials and meta-analyses; 12 Confidence intervals and sample sizes; 13 Special topics; PART II STATISTICAL GUIDELINES AND CHECKLISTS"]
[{"$nulls":4},"14 Statistical guidelines for contributors to medical journals 15 Statistical checklists; PART III NOTATION, SOFTWARE, AND  TABLES; 16 Notation; 17 Computer software for calculating confidence intervals (CIA); 18 Tables for the calculation of confidence intervals; Index"]
[null,null,null,"Sommario/riassunto","This highly popular introduction to confidence intervals has been thoroughly updated and expanded. It includes methods for using confidence intervals, with illustrative worked examples and extensive guidelines and checklists to help the novice."]
[null,"2.","Record Nr.",null,"UNINA9910298410703321"]
[null,null,"Autore",null,"Iversen Patrick L"]
[null,null,"Titolo",null,"Molecular Basis of Resilience : Adapting to a Changing Environment / / by Patrick L. Iversen"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2018"]
[null,null,"ISBN",null,"3-319-98164-1"]
[null,null,"Edizione",null,"[1st ed. 2018.]"]
[null,null,"Descrizione fisica",null,"1 online resource (325 pages)"]
[null,null,"Disciplina",null,"579.25"]
[null,null,"Soggetti",null,"Pharmacology"]
[{"$nulls":4},"Molecular biology"]
[{"$nulls":4},"Pharmacology/Toxicology"]
[{"$nulls":4},"Molecular Medicine"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Prologue -- Preface -- Social Entropy -- Virus among Us -- Non-linear Anomalies -- Bacterial Infectious Disease -- Cure 2000 -- Chemicals in the Environment -- Immune Defense -- Metabolic Defense -- Analog Genetics -- Eteplirsen -- Regulating Resilience."]
[null,null,null,"Sommario/riassunto","This book illuminates mechanisms of resilience. Threats and defense systems lead to adaptive changes in gene expression. Environmental conditions may dampen adaptive responses at the level of RNA expression. The first seven chapters elaborate threats to human health. Human populations spontaneously invade niche boundaries exposing us to threats that drive the resilience process. Emerging RNA viruses are a significant threat to human health. Antiviral drugs are reviewed and how viral genomes respond to the environment driving genome sequence plasticity. Limitations in predicting the human outcome are described in “nonlinear anomalies.” An example includes medical countermeasures for Ebola and Marburg viruses under the “Animal Rule.” Bacterial infections and a review of antibacterial drugs and bacterial resilience mediated by horizontal gene transfer follow. Chapter 6 shifts focus to cancer and discovery of novel therapeutics for leukemia. The spontaneous resolution of AML in children with Down syndrome highlights human resilience. Chapter 7 explores chemicals in the environment. Examples of chemical carcinogenesis illustrate how chemicals disrupt genomes. Historic research ignored RNA damage "]
[{"$nulls":4},"from chemically induced nucleic acid damage. The emergence of important forms of RNA and their possible role in resilience is proposed. Chapters 8-10 discuss threat recognition and defense systems responding to improve resilience. Chapter 8 describes the immune response as a threat recognition system and response via diverse RNA expression. Oligonucleotides designed to suppress specific RNA to manipulate the immune response including exon-skipping strategies are described. Threat recognition and response by the cytochrome P450 enzymes parallels immune responses. The author proposes metabolic clearance of small molecules is a companion to the immune system. Chapter 10 highlights RNA diversity expressed from a single gene. Molecular Resilience lists paths to RNA transcriptome plasticity forms the molecular basis for resilience. Chapter 11 is an account of ExonDys 51, an approved drug for the treatment of Duchenne muscular dystrophy. Chapter 12 addresses the question “what informs molecular mechanisms of resilience?” that drives the limits to adaptation and boundaries for molecular resilience. He speculates that radical oxygen, epigenetic modifications, and ligands to nuclear hormone receptors play critical roles in regulating molecular resilience."]
[null,"3.","Record Nr.",null,"UNINA9910162818703321"]
[null,null,"Autore",null,"Bell David M."]
[null,null,"Titolo",null,"Rethinking Utopia : place, power, affect / / David M. Bell"]
[null,null,"Pubbl/distr/stampa",null,"New York, N.Y. : , : Routledge, , [2017]"]
[null,null,"ISBN",null,"1-317-48670-6"]
[{"$nulls":4},"1-315-70969-4"]
[{"$nulls":4},"1-317-48671-4"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (189 pages)"]
[null,null,"Collana",null,"Routledge Innovations in Political Theory ; ; 71"]
[null,null,"Disciplina",null,"307.770973"]
[{"$nulls":4},"335.02"]
[null,null,"Soggetti",null,"Utopias - United States"]
[{"$nulls":4},"Utopias - History"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references at the end of each chapters and index."]
[null,null,"Nota di contenuto",null,"1. Rethinking the present ; or, our post-Utopian, most-utopian, anti-Utopian dystopia -- 2. Rethinking contemporary Utopianism -- 3. Rethinking Utopian studies -- 4. Rethinking the good place -- 5. Rethinking the no-good place."]
[null,null,null,"Sommario/riassunto","Over five hundred years since it was named, utopia remains a vital concept for understanding and challenging the world(s) we inhabit, even in - or rather because of - the condition of 'post-utopianism' that supposedly permeates them. In Rethinking Utopia David M. Bell offers a diagnosis of the present through the lens of utopia and then, by rethinking the concept through engagement with utopian studies, a variety of 'radical' theories and the need for decolonizing praxis, shows how utopianism might work within, against and beyond that which exists in order to provide us with hope for a better future. He proposes paying a 'subversive fidelity' to utopia, in which its three constituent terms: 'good' (eu), 'place' (topos), and 'no' (ou) are rethought to assert the importance of immanent, affective relations. The volume engages with a variety of practices and forms to articulate such a utopianism, including popular education/critical pedagogy; musical improvisation; and utopian literature. The problems as well as the possibilities of this utopianism are explored, although the problems are often revealed to be possibilities, provided they are subject to material challenge. Rethinking Utopia offers a way of thinking about (and perhaps "]
[{"$nulls":4},"realising) utopia that helps overcome some of the binary oppositions structuring much thinking about the topic. It allows utopia to be thought in terms of place and process; affirmation and negation; and the real and the not-yet. It engages with the spatial and affective turns in the social sciences without ever uncritically being subsumed by them; and seeks to make connections to indigenous cosmologies. It is a cautious, careful, critical work punctuated by both pessimism and hope; and a refusal to accept the finality of this or any world."]