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[null,"1.","Record Nr.",null,"UNINA9910298332803321"]
[null,null,"Titolo",null,"Ras Superfamily Small G Proteins: Biology and Mechanisms 1 : General Features, Signaling / / edited by Alfred Wittinghofer"]
[null,null,"Pubbl/distr/stampa",null,"Vienna : , : Springer Vienna : , : Imprint : Springer, , 2014"]
[null,null,"ISBN",null,"3-7091-1806-9"]
[null,null,"Edizione",null,"[1st ed. 2014.]"]
[null,null,"Descrizione fisica",null,"1 online resource (447 p.)"]
[null,null,"Disciplina",null,"570"]
[{"$nulls":4},"571.6"]
[{"$nulls":4},"572.6"]
[{"$nulls":4},"572633"]
[null,null,"Soggetti",null,"Cytology"]
[{"$nulls":4},"Proteins"]
[{"$nulls":4},"Cell Biology"]
[{"$nulls":4},"Protein Science"]
[{"$nulls":4},"Protein Structure"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index at the end of each chapters."]
[null,null,"Nota di contenuto",null,"Evolution of the Ras Superfamily of GTPases -- The structure of the G domain of the Ras superfamily -- GEFs and GAPs: Mechanisms and Structures -- Bacterial protein toxins acting on small GTPases -- Posttranslational modifications of small G proteins -- Targeting the Raf-MEK-ERK Mitogen-Activates Protein Kinase Cascade for the Treatment of RAS Mutant Cancers -- RAS Genes and Cancer -- The Spatial Organization of Ras Signaling -- Ras Nanoclusters -- Mouse Models of Ras induced Tumors and Developmental Disorders -- Rap signaling -- The coordinated biology and signaling partners of Ral G-proteins -- Structure and Function of the mTOR Activator Rheb -- Classical Rho proteins: Biochemistry of molecular switch function and regulation -- Atypical Rho family members -- Molecular Structures, Cellular Functions and Physiological Roles of Rho Effectors -- Principles driving the spatial organization of Rho GTPase signaling at synapses -- Rho GTPases in Cancer."]
[null,null,null,"Sommario/riassunto","This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated "]
[{"$nulls":4},"by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field."]