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[null,"1.","Record Nr.",null,"UNISA996466643803316"]
[null,null,"Titolo",null,"Approximation and optimization : proceedings of the International Seminar held in Havana, Cuba, Jan. 12-16, 1987. / / A. Gomez [and three three others], editors"]
[null,null,"Pubbl/distr/stampa",null,"Berlin : , : Springer-Verlag, , [1988]"]
[{"$nulls":4},"©1988"]
[null,null,"ISBN",null,"3-540-46005-5"]
[null,null,"Edizione",null,"[1st ed. 1988.]"]
[null,null,"Descrizione fisica",null,"1 online resource (VIII, 284 p.)"]
[null,null,"Collana",null,"Lecture notes in mathematics ; ; 1354"]
[null,null,"Disciplina",null,"511.4"]
[null,null,"Soggetti",null,"Approximation theory"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,"Nota di contenuto",null,"Nonparametric polynomial density estimation in the L P norm -- Local spline interpolation schemes in one and several variables -- On the rate of rational approximation of analytic functions -- Parametric optimization: Pathfollowing with jumps -- Optimization problems in the robustness analysis of linear state space systems -- A principle of contamination in best polynomial approximation -- Nearby sets and centers -- Approximation by lipschitz functions and its application to boundary value of cauchy-type integrals -- Asymptotics for the ratio of the leading coefficients of orthogonal polynomials associated with a jump modification -- Convergence of pade approximats in a non-commutative algebra -- Subsets of unicity in uniform approximation -- On qualitative Korovkin theorems with a-distance -- Relative asymptotics of orthogonal polynomials with respect to varying measures II -- On the rational approximation of HP functions in the LP(?) metric -- On the trajectories of inclined oil-wells -- On some contributions of Halasz to the turan power-sum theory -- On the m-th row of newton type (?,?)-PADF tables and singllar points -- On simul taneous rational interpolants of type (?,?) -- Généralisation de formules de bornage de L-I et applications aux Lp -- On C0-semigroups in a space of bounded continuous functions in the case of entrance or natural boundary points -- On the approximation of Riemann integrable functions by bernstein polynomials -- Optimization criteria for multivariate strata construction -- Proof of two conjectures by G. Chen and D. L. Russell on structural damping for elastic systems -- An iterative aggregation algorithm for linear programming -- Optimal "]
[{"$nulls":4},"control of non linear retarded systems with phase constraints."]
[null,"2.","Record Nr.",null,"UNINA9910298331703321"]
[null,null,"Titolo",null,"Systems analysis of chromatin-related protein complexes in cancer / / Andrew Emili, Jack Greenblatt, Shoshana Wodak, editors"]
[null,null,"Pubbl/distr/stampa",null,"New York, : Springer Science, 2014"]
[null,null,"ISBN",null,"1-4614-7931-2"]
[null,null,"Descrizione fisica",null,"1 online resource (320 p.)"]
[null,null,"Disciplina",null,"570"]
[{"$nulls":4},"572.6"]
[{"$nulls":4},"599935"]
[{"$nulls":4},"610"]
[null,null,"Soggetti",null,"Chromosomal proteins"]
[{"$nulls":4},"Tumor proteins"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Preface -- Systematic proteomic analysis of histone demethylating enzymes linked to cancer -- Histone methylating protein complexes in cancer -- Chromatin protein-protein interaction networks linked to cancer -- Structural genomics and drug discovery for chromatin-related protein complexes involved in histone tail recognition -- Transcription factories and global chromatin (enhancer) interactions in cancer -- Long ncRNAs associated with chromatin complexes and their role in cancer -- Familial and somatic mutations of histone modifying enzymes in cancer -- Chromatin regulators arising from RNAi screens of transformed cancer cell lines -- Chromatin complexes in cancer -- Exploring dynamics of chromatin complexes in cancer based on quantitative proteomics -- Regulatory ncRNAs and their targets -- ncRNA regulatory networks in cancer -- Decoding BAF remodelling complexes in cancer -- Mediator/cohesin complex in cancer -- miRNAs targeting chromatin-related protein complexes regulate epigenetic states in cancer -- Polycomb group protein complexes in cancer stem cells -- Genetic interactions between chromatin factors in cancer cell lines -- Chromatin complexes in DNA repair -- Chromatin complexes in chromosome segregation -- Evolution, co-expression and domain architecture of CM complexes linked to cancer  -- Index."]
[null,null,null,"Sommario/riassunto","Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They "]
[{"$nulls":4},"also underlie  environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic \"code\" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned “on” or “off” and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines  - namely, the \"readers, writers and erasers\" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks."]