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[null,"1.","Record Nr.",null,"UNINA9910298321003321"]
[null,null,"Titolo",null,"MFG-E8 and Inflammation / / edited by Ping Wang"]
[null,null,"Pubbl/distr/stampa",null,"Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2014"]
[null,null,"ISBN",null,"9401787654"]
[null,null,"Edizione",null,"[1st ed. 2014.]"]
[null,null,"Descrizione fisica",null,"1 online resource (209 p.)"]
[null,null,"Disciplina",null,"637.14"]
[null,null,"Soggetti",null,"Milkfat"]
[{"$nulls":4},"Inflammation"]
[{"$nulls":4},"Pathology"]
[{"$nulls":4},"Cancer Research"]
[{"$nulls":4},"Immunology"]
[{"$nulls":4},"Cell Biology"]
[{"$nulls":4},"Biomedicine, general"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references at the end of each chapters and index."]
[null,null,"Nota di contenuto",null,"MFG-E8: Origin, Structure, Expression, Functions and Regulation / Kenzi Oshima, Takehiko Yasueda, Shunsuke Nishio, Tsukasa Matsuda -- MFG-E8 as a Marker for Apoptotic, Stressed and Activated Cells / Kristine Blans, Jan Trige Rasmussen -- Role of MFG-E8 in Protection of Intestinal Epithelial Barrier Function and Attenuation of Intestinal Inflammation / Suhail Akhtar, Xiao Wang, Heng-Fu Bu, Xiao-Di Tan -- MFG-E8 in the Blood Cell Homeostasis and Coagulation / Swapan Kumar Dasgupta, Perumal Thiagarajan -- MFG-E8 in the Vascular System / Xuan Li, Nicolas Deroide, Ziad Mallat -- Autoimmune Diseases and the Role of MFG-E8 / Rikinari Hanayama -- Novel Therapeutic for Systemic Inflammation: Role of MFG-E8 / Asha Jacob, Ping Wang -- Anti-Inflammatory Role of MFG-E8 in the Intestinal Tract / Shunji Ishihara, Ryusaku Kusunoki, Yoshikazu Kinoshita -- MFG-E8 and Acute Lung Injury / Monowar Aziz, Ping Wang -- Role of MFG-E8 in the Brain / Monowar Aziz, Ping Wang."]
[null,null,null,"Sommario/riassunto","After the discovery of milk fat globule-epidermal growth factor-factor 8 (MFG-E8) about two decades ago, a new era of delineating its potential beneficial role in several inflammatory diseases has begun to spout from the bench to translational research.  In MFG-E8 and Inflammation, the editor and contributors have gathered a remarkable "]
[{"$nulls":4},"collection covering novel discoveries on the rapidly growing field of MFG-E8 and Inflammation which includes not only the findings from their individual lobotomies, but also from a host of pioneering researchers of this field. MFG-E8 and Inflammation starts by describing the origin, structure, expression, functions and regulation of MFG-E8, and then on continues thoughtfully exploring its potentiality as a marker for apoptotic, stressed and activated cells.  The topics cover the cellular and physiological function of MFG-E8, especially its role in efficient phagocytosis of apoptotic cells, intestinal barrier function, blood cell homeostasis and coagulation, and in the maintenance of the intact vascular system.  The role of MFG-E8 in macrophages, neutrophils, lymphocytes, dendritic cells, platelets, as well as non-hematopoietic cells is adequately described in the book.  The chapters also contain several lucid discussions on the recent discoveries of the roles of MFG-E8 in the autoimmune diseases, sepsis, tissue ischemia-reperfusion, hemorrhage, inflammatory bowel disease, acute lung injury, asthma, lung fibrosis, stroke, prion disease and Alzheimer’s disease with the potential focus on elucidating novel mechanistic pathways. MFG-E8 and Inflammation is an indispensable resource for scientists and clinical researchers working on fundamental or applied aspects of MFG-E8 pathobiology.  This book explores, dissects and reviews several noteworthy findings and striking future perspectives which not only rewrite the disease pathophysiology, but also update our understanding towards attaining novel therapeutic potentials against various inflammatory diseases.       ."]