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[null,"1.","Record Nr.",null,"UNISA996390218303316"]
[null,null,"Autore",null,"Jerome Stephen <fl. 1604-1650.>"]
[null,null,"Titolo",null,"Origens repentance: after he had sacrificed to the idols of the heathen [[electronic resource] ] : Gathered from Suidas, Nicephorus, Osiander, and the Greeke and Latine coppies in Origens workes; illustrated and applied to the case of euery poore penitent ... Diuided into three sections: containing 1 Origens fearefull fall. 2 His behauiour in it. 3 His worthy and sound conuersion. Together with Origens life and death, and other materiall obseruations. Written by Stephen Ierom, Master of Arts, and preacher of the towne of Newcastle; first for his owne exercise, and now published for the good of others"]
[null,null,"Pubbl/distr/stampa",null,"Printed at London, : By Iohn Beale, for Roger Iackson, and are to be sold at his shop neere Fleet-Conduit, 1619"]
[null,null,"Descrizione fisica",null,"[20], 63, [1] p"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","In verse."]
[{"$nulls":4},"Reproduction of the original in the British Library."]
[null,null,null,"Sommario/riassunto","eebo-0018"]
[null,"2.","Record Nr.",null,"UNINA9910298269003321"]
[null,null,"Autore",null,"Baici Antonio"]
[null,null,"Titolo",null,"Kinetics of Enzyme-Modifier Interactions : Selected Topics in the Theory and Diagnosis of Inhibition and Activation Mechanisms / / by Antonio Baici"]
[null,null,"Pubbl/distr/stampa",null,"Vienna : , : Springer Vienna : , : Imprint : Springer, , 2015"]
[null,null,"ISBN",null,"3-7091-1402-0"]
[null,null,"Edizione",null,"[1st ed. 2015.]"]
[null,null,"Descrizione fisica",null,"1 online resource (503 p.)"]
[null,null,"Disciplina",null,"570"]
[{"$nulls":4},"570285"]
[{"$nulls":4},"571.4"]
[{"$nulls":4},"572.6"]
[null,null,"Soggetti",null,"Enzymology"]
[{"$nulls":4},"Proteins"]
[{"$nulls":4},"Bioinformatics"]
[{"$nulls":4},"Computational biology"]
[{"$nulls":4},"Biophysics"]
[{"$nulls":4},"Protein-Ligand Interactions"]
[{"$nulls":4},"Computer Appl. in Life Sciences"]
[{"$nulls":4},"Biological and Medical Physics, Biophysics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references at the end of each chapters and index."]
[null,null,"Nota di contenuto",null,"Basic Knowledge -- The General Modifier Mechanism -- Taxonomy of Enzyme-Modifier Interactions and the Specific Velocity Plot -- Complements to Enzyme-Modifier Interactions -- The Basic Mechanisms of Inhibition and Nonessential Activation -- Multiple Enzyme-Modifier Interactions -- Multiple Interactions: Essential Activation and Liberation -- Slow-Onset Enzyme Inhibition -- Enzyme Inactivation with a Note on the Significance of Slow Modification Processes.- Dichotomous Keys to Enzyme-Modification Mechanisms. ."]
[null,null,null,"Sommario/riassunto","The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the "]
[{"$nulls":4},"allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism."]