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[null,"1.","Record Nr.",null,"UNINA9910298039203321"]
[null,null,"Titolo",null,"Liver regeneration : basic mechanisms, relevant models and clinical applications / / edited by Udayan Apte, PhD Dabt, Associate Professor, Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS, USA"]
[null,null,"Pubbl/distr/stampa",null,"London, UK ; ; San Diego, CA ; ; Waltham, MA : , : Elsevier, , [2015]"]
[{"$nulls":4},"©2015"]
[null,null,"ISBN",null,"0-12-800431-2"]
[null,null,"Descrizione fisica",null,"1 online resource (326 p.)"]
[null,null,"Disciplina",null,"611.36"]
[null,null,"Soggetti",null,"Liver - Regeneration"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Front Cover; Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications; Copyright; Dedication; Contents; Contributors; Preface; Part I: Introduction; Chapter 1: Liver Regeneration: An Introduction; 1.1. History; 1.2. Models of Liver Regeneration; 1.3. Mechanisms of Liver Regeneration; 1.4. Regeneration Using Progenitor Cells; 1.5. Mitogen-Induced Hepatocyte Proliferation; 1.6. Frontiers; References; Part II: Methods to Assess Liver Regeneration; Chapter 2: Models to Study Liver Regeneration; 2.1. Introduction; 2.2. Main Models; 2.2.1. Partial Hepatectomy"]
[{"$nulls":4},"2.2.1.1. PH Procedure2.2.1.2. Establishing Baseline, Time Course, and Proper Controls; 2.2.2. Models of Liver Regeneration After Chemical-Induced Liver Injury; 2.2.2.1. d-Galactosamine: Mechanism of Hepatotoxicity; 2.2.2.1.1. d-Galactosamine: Hepatic Regenerative Response; 2.2.2.2. Carbon Tetrachloride: Mechanism of Hepatotoxicity; 2.2.2.2.1. CCl4: Hepatic Regenerative Response; 2.2.2.3. Thioacetamide; 2.2.2.4. Acetaminophen; 2.2.2.5. Regeneration After Ischemia/Reflow; 2.2.2.5.1. Mechanisms of I/R Injury and Repair; 2.3. Alternate Models of Liver Growth; 2.3.1. Postnatal Liver Growth"]
[{"$nulls":4},"2.3.2. Pregnancy-Induced Liver Growth2.4. Models to Study HPCs; 2.4.1. 2-Acetylaminofluorene Combined with Partial Hepatectomy; 2.4.2. The DDC Diet Model; 2.4.3. The CDE Diet Model; 2.5. Assays Used to Assess Liver Regeneration; 2.5.1. PCNA Immunolocalization; 2.5.2. 3H-TdR and BrdU Incorporation; 2.5.3. Ki67 Immunolocalization; 2.6. Additional Methods; References; Chapter 3: Liver Regeneration in "]
[{"$nulls":4},"Zebrafish; 3.1. Introduction; 3.2. The Therapeutic Impact of Zebrafish Research; 3.3. Adult Liver Anatomy and Physiology; 3.4. Liver Regeneration Following Partial Hepatectomy"]
[{"$nulls":4},"3.5. Drug-Induced Hepatotoxicity3.6. Genetic Hepatocyte Ablation; 3.7. Summary; References; Part III: Molecular Mechanisms of Liver Regeneration; Chapter 4: The Priming and Progression Theory of Liver Regeneration; 4.1. Overview of Studies of Liver Regeneration; 4.2. Salient Features of Liver Regeneration Prior to 1970; 4.3. Identifying Hepatomitogens in the 1970s-1980s; 4.4. 1990s: Development of the Priming and Progression Model, with a Focus on Inflammatory Stimuli During Regeneration; 4.5. Priming Alone Versus Priming and Progression: 1/3 Versus 2/3 Hepatectomy"]
[{"$nulls":4},"4.6. Controversies Regarding the Importance of Priming in Regeneration4.7. Recent Insight into Cell-Cycle ``Competency;́́ 4.8. The Role of NPCs in Priming and Progression; 4.9. Future Directions; References; Chapter 5: Extracellular Signals Involved in Liver Regeneration: Direct and Auxiliary Mitogens; 5.1. Hepatocyte Growth Assay; 5.2. Complete Versus Auxiliary Mitogens; 5.3. Complete or Direct Mitogens; 5.3.1. Hepatocyte Growth Factor; 5.3.2. Ligands of EGFR; 5.4. Auxiliary Mitogens; 5.5. TNFα; 5.6. IL6; 5.7. Norepinephrine; 5.8. Insulin; 5.9. Summary; References"]
[{"$nulls":4},"Chapter 6: Developmental Pathways in Liver Regeneration-I"]
[null,null,null,"Sommario/riassunto","Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications presents cutting-edge information on liver regeneration research through an integrated, systems-wide perspective. The book addresses discoveries on hepatic progenitor cells, liver regeneration after chemical damage, and liver regeneration as a prime therapy for liver failure and disease.    By addressing the urgent need for translating basic research findings into clinically relevant modalities and potential therapeutic applications, the book provides the data needed to improve liver patient management.    Hundre"]