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[null,"1.","Record Nr.",null,"UNINA9910275041103321"]
[null,null,"Autore",null,"Allard Jérôme-Olivier"]
[null,null,"Titolo",null,"Jeu vidéo et livre / / Björn-Olav Dozo, Fanny Barnabé"]
[null,null,"Pubbl/distr/stampa",null,"Liège, : Presses universitaires de Liège, 2018"]
[null,null,"ISBN",null,"979-1-03-651235-3"]
[null,null,"Soggetti",null,"Art"]
[{"$nulls":4},"Literary Theory &amp; Criticism"]
[{"$nulls":4},"jeu vidéo"]
[{"$nulls":4},"game studies"]
[{"$nulls":4},"rapports intermédiatiques"]
[{"$nulls":4},"transmedia"]
[null,null,"Lingua di pubblicazione",null,"Francese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Si les rapports entre jeu vidéo et cinéma suscitent depuis longtemps l’intérêt des milieux académiques, les relations, échanges et points de passage entre le livre et le jeu vidéo constituent pour leur part un domaine de recherche toujours en friche. Pourtant, les interactions entre ces deux médias sont loin d’être des exceptions et les disciplines qui les étudient (les game studies et l’histoire du livre) sont connectées par une certaine affinité méthodologique : tous deux ont un fondement profondément interdisciplinaire ; tous deux rassemblent, autour d’un objet commun, des chercheurs issus d’horizons très différents. Cette parenté disciplinaire, ajoutée à la richesse des constants échanges entre livre et jeu vidéo, a encouragé la conception de cet ouvrage collectif consacré à la rencontre entre le médium vidéoludique et son voisin livresque."]
[null,"2.","Record Nr.",null,"UNINA9910830024003321"]
[null,null,"Titolo",null,"The aptamer handbook [[electronic resource] ] : functional oligonucleotides and their applications / / edited by Sven Klussmann"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim, : Wiley-VCH, c2006"]
[null,null,"ISBN",null,"1-280-72339-4"]
[{"$nulls":4},"9786610723393"]
[{"$nulls":4},"3-527-60819-2"]
[{"$nulls":4},"3-527-60791-9"]
[null,null,"Descrizione fisica",null,"1 online resource (520 p.)"]
[null,null,"Disciplina",null,"572.85"]
[null,null,"Soggetti",null,"Oligonucleotides"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"The Aptamer Handbook; Contents; Preface; Foreword; List of Contributors; Part 1 History and Theoretical Background; 1 In Vitro Selection of Functional Oligonucleotides and the Origins of Biochemical Activity; 1.1 Introduction; 1.2 A Brief History of In Vitro Selection; 1.3 Lessons from the Aptamers, Ribozymes, Deoxyribozymes Generated by In Vitro Selection; 1.4 Synthetic Approaches to Understanding the Natural Origins of Function; 1.5 Recent Technological Developments and Future Directions; 1.6 Conclusion; Acknowledgments; References"]
[{"$nulls":4},"2 Mathematical Models on RNA Evolution, Simulations In Silico, and Concepts for In Vitro Selection2.1 From Early Experiments and Theories to the Concept of Neutral Networks; 2.1.1 Evolution in the Test Tube; 2.1.2 Kinetic Theory of the Evolution of Molecules; 2.1.3 Sequence Space and Shape Space; 2.2 RNA Structures, Thermodynamics and Kinetic Folding; 2.2.1 Secondary Structures of Minimum Free Energies; 2.2.2 Inverse Folding; 2.2.3 Suboptimal Conformations and Kinetic Folding; 2.2.4 Cofolding and DNA Parameters; 2.3 Neutral Networks and In Silico Evolution of Molecules"]
[{"$nulls":4},"2.3.1 Neutral Networks in Sequence Space2.3.2 RNA Evolution In Silico; 2.3.3 Lessons from Evolution In Silico; 2.4 Designed and Natural RNA Switches; 2.5 Outlook on Future Problems in RNA Design; Acknowledgments; References; 3 Fitness Landscapes, Error Thresholds, and Cofactors in Aptamer Evolution; 3.1 Introduction; 3.2 Functionality Landscapes Inferred from Examples; 3.2.1 Fitness Landscape; 3.2.2 "]
[{"$nulls":4},"Damage Selection Experiments with Ribozymes; 3.2.3 Construction of the Fitness Landscape; 3.2.3.1 Compatible Structure; 3.2.3.2 Mispairs; 3.2.3.3 Critical Sites; 3.2.3.4 Predicted Structure"]
[{"$nulls":4},"3.2.4 Case Study: The Fitness Landscape of the Neurospora VS Ribozyme3.2.4.1 Compatible Structure of the VS Ribozyme; 3.2.4.2 Allowed Mispairs in the VS Ribozyme; 3.2.4.3 Critical Sites in the VS Ribozyme; 3.2.4.4 Predicted Structure for the VS Ribozyme; 3.2.4.5 Properties of the Estimated Fitness Landscape for the VS Ribozyme; 3.3 Error Thresholds Inferred from Functional Landscapes: The \"Realistic\" Error Threshold of the Neurospora VS Ribozyme; 3.4 Looking for Catalytic Partners: Cofactors and Aptamers; 3.4.1 Co-ribozymes (cofactor-assisted ribozymes); 3.4.2 Aptazymes"]
[{"$nulls":4},"3.5 The Use of Coenzymes: From the RNA World to the Protein World via Translation and the Genetic Code3.6 Outlook; Acknowledgments; References; Part 2 In Vitro Selection of Target-binding Oligonucleotides; 4 Aptamers to Small Molecules; 4.1 Introduction; 4.2 Aptamers to Nucleotides/Nucleosides/Nucleobases; 4.3 Aptamers to Cofactors; 4.4 Aptamers to Amino Acids; 4.5 Aptamers to Carbohydrates; 4.6 Aptamers to Natural Products; 4.7 Aptamers to Organic or Fluorescent Dyes; 4.8 The Chimeric Approach for Aptamer Selection; 4.9 Conclusion; Acknowledgments; References; 5 Aptamers to Antibiotics"]
[{"$nulls":4},"5.1 Introduction"]
[null,null,null,"Sommario/riassunto","In The Aptamer Handbook, leading scientists from academia as well as biotech and pharma companies introduce the revolutionary concept of designing RNA and DNA oligonucleotides with novel functions by in vitro selection. These functions comprise high affinity binding (aptamers), catalytic activity (ribozymes and deoxyribozymes) or combinations of binding and catalytic properties (aptazymes).Basic concepts and technologies describing in detail how these functional oligonucleotides can be identified are presented. Numerous examples demonstrate the versatility of in vitro selected oligonucleot"]