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[null,"1.","Record Nr.",null,"UNINA9910220055803321"]
[null,null,"Autore",null,"Allegra Via"]
[null,null,"Titolo",null,"Protein Phosphorylation in Health and Disease"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2016"]
[null,null,"Descrizione fisica",null,"1 online resource (122 p.)"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[null,null,"Soggetti",null,"Genetics (non-medical)"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Protein phosphorylation is one of the most abundant reversible post-translational modifications in eukaryotes. It is involved in virtually all cellular processes by regulating protein function, localization and stability and by mediating protein-protein interactions. Furthermore, aberrant protein phosphorylation is implicated in the onset and progression of human diseases such as cancer and neurodegenerative disorders. In the last years, tens of thousands of in vivo phosphorylation events have been identified by large-scale quantitative phospho-proteomics experiment suggesting that a large fraction of the proteome might be regulated by phosphorylation. This data explosion is increasingly enabling the development of computational approaches, often combined with experimental validation, aiming at prioritizing phosphosites and assessing their functional relevance. Some computational approaches also address the inference of specificity determinants of protein kinases/phosphatases and the identification of phosphoresidue recognition domains. In this context, several challenging issues are still open regarding phosphorylation, including a better understanding of the interplay between phosphorylation and allosteric regulation, agents and mechanisms disrupting or promoting abnormal phosphorylation in diseases, the identification and modulation of novel phosphorylation inhibitors, and so forth. Furthermore, the determinants of kinase and phosphatase recognition and binding specificity are still unknown in several cases, as well as the impact of disease mutations on phosphorylation-mediated signaling. The articles included in this Research Topic illustrate the very diverse aspects of phosphorylation, ranging from structural changes induced "]
[{"$nulls":4},"by phosphorylation to the peculiarities of phosphosite evolution. Some also provide a glimpse into the huge complexity of phosphorylation networks and pathways in health and disease, and underscore that a deeper knowledge of such processes is essential to identify disease biomarkers, on one hand, and design more effective therapeutic strategies, on the other."]
[null,"2.","Record Nr.",null,"UNINA9910263752803321"]
[null,null,"Autore",null,"Roussel Jimmy"]
[null,null,"Titolo",null,"Trace Element Supplementation As a Management Tool for Anaerobic Digester Operation : Benefits and Risks"]
[null,null,"Pubbl/distr/stampa",null,"IWA Publishing, 2018"]
[{"$nulls":4},"London : , : IWA Publishing, , 2018"]
[{"$nulls":4},"©2018"]
[null,null,"ISBN",null,"1-5231-2327-3"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource"]
[null,null,"Disciplina",null,"628.354"]
[null,null,"Soggetti",null,"Water supply & treatment"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Cover -- Introduction -- How to (choose to read) -- Do I need to add trace elements to my digester? -- What are the benefits of adding trace elements to a digester? -- Which trace elements do I need to add to my digester? -- Strategy for trace elements supplementation -- Risks linked with TE supplementation -- COST action ES 1302 -- References -- Credits."]
[null,null,null,"Sommario/riassunto","\" This guide is intended for use by industry stakeholders, decision-makers and digester operators in navigating the topic of trace element (TE) supplementation as a management tool for anaerobic digester operation.\nThe subject is the application of TE, and supplementation regimes in anaerobic waste-conversion biotechnologies, such as biogas digesters. TE is a term used to include a wide range of micronutrients essential for the microbial community underpinning AD. TE mostly includes elements from the metal groups (e.g. cobalt, nickel, zinc and tungsten) but also other elemental groups, such as metalloids (e.g. selenium). TE are dosed to anaerobic digesters to boost biological activity and to increase biogas production rates. Little is understood about the concentrations and dosing strategies best suited to sustained supplementation and stable performance in anaerobic biotechnologies.\nA range of companies offer proprietary blends of trace elements for supplementation of anaerobic digesters. Very little joined-up information is available on the concentrations of individual TE best suited to improved digester performance. Moreover, typically no "]
[{"$nulls":4},"attention whatsoever is paid to the bioavailability of TE dosed to digesters i.e. despite high concentrations, TE may not be available for uptake by the microorganisms underpinning the digestion process.\nBased on extensive engagement with a range of stakeholders throughout the course of the recent EU COST Action on ‘The ecological roles of trace metals in anaerobic biotechnologies’, and particularly on feedback from industrial partners, it is clear that such a guide is needed by industry stakeholders, decision-makers and operators of anaerobic digesters.\""]