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[null,"1.","Record Nr.",null,"UNINA9910254147703321"]
[null,null,"Autore",null,"Terasaka Naohiro"]
[null,null,"Titolo",null,"Applications of Aminoacylation Ribozymes That Recognize the 3′-end of tRNA / / by Naohiro Terasaka"]
[null,null,"Pubbl/distr/stampa",null,"Tokyo : , : Springer Japan : , : Imprint : Springer, , 2017"]
[null,null,"ISBN",null,"9784431565154"]
[{"$nulls":4},"9784431565178 (e-book)"]
[null,null,"Edizione",null,"[1st ed. 2017.]"]
[null,null,"Descrizione fisica",null,"1 online resource (XII, 89 p. 38 illus., 28 illus. in color.)"]
[null,null,"Collana",null,"Springer Theses, Recognizing Outstanding Ph.D. Research, , 2190-5053"]
[null,null,"Disciplina",null,"540"]
[null,null,"Soggetti",null,"Bioorganic chemistry"]
[{"$nulls":4},"Catalysis"]
[{"$nulls":4},"Nucleic acids"]
[{"$nulls":4},"Biotechnology"]
[{"$nulls":4},"Bioorganic Chemistry"]
[{"$nulls":4},"Nucleic Acid Chemistry"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","\"Doctoral Thesis accepted by the University of Tokyo, Tokyo, Japan.\""]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,"Nota di contenuto",null,"General introduction -- Discovery of human microRNA precursor binding to folic acid by small RNA transcriptomic SELEX -- Orthogonal ribosome-tRNAs pair by engineering of peptidyl transferase center -- General conclusion."]
[null,null,null,"Sommario/riassunto","In this thesis, applications of aminoacylation ribozymes named flexizymes are described. Flexizymes have the following unique characteristics: (i) substrate RNA is recognized by two consecutive base pairs between the 3'-end of substrate RNA and the 3'-end of the flexizyme; (ii) these base pairs can be substituted with other base pairs; and (iii) various activated amino acids can be used as substrates including both canonical and noncanonical amino acids. This flexible aminoacylation of RNAs by flexizymes was used to label endogenous tRNAs to be removed, and in vitro selection using the tRNA-depleted library enabled the discovery of the novel interaction between the microRNA precursor and metabolites. Flexizymes are also used to prepare various aminoacyl-tRNAs bearing mutations at the 3'-end to engineer the translation machinery and to develop the orthogonal translation machinery. The first part of the research demonstrated that SELEX is appropriate for discovering the interaction between small RNA "]
[{"$nulls":4},"and ligands, and suggested that more RNA motif binding to small molecules exists in small RNAs. The second part opened a door to new opportunities for in vitro synthetic biology involving the engineering of the genetic codes and translation machineries. This research also indicated the great potential of aminoacylation by flexizymes to be applied in various fields of RNA research, which is beneficial for RNA researchers."]
[null,"2.","Record Nr.",null,"UNINA9910309741303321"]
[null,null,"Autore",null,"Brommer Sarah"]
[null,null,"Titolo",null,"Sprachliche Muster : Eine induktive korpuslinguistische Analyse wissenschaftlicher Texte / / Sarah Brommer"]
[null,null,"Pubbl/distr/stampa",null,"Berlin/Boston, : De Gruyter, 2018"]
[{"$nulls":4},"Berlin ; ; Boston : , : De Gruyter, , [2018]"]
[{"$nulls":4},"©2018"]
[null,null,"ISBN",null,"3-11-057366-0"]
[null,null,"Descrizione fisica",null,"1 online resource (xvi, 422 pages)"]
[null,null,"Collana",null,"Empirische Linguistik / Empirical Linguistics ; ; 10"]
[null,null,"Disciplina",null,"410.188"]
[null,null,"Soggetti",null,"German language - Style"]
[{"$nulls":4},"Academic writing"]
[{"$nulls":4},"Corpora (Linguistics)"]
[{"$nulls":4},"Discourse analysis"]
[null,null,"Lingua di pubblicazione",null,"Tedesco"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,"Nota di contenuto",null,"1. Einleitung -- I. Theoretischer Teil: Wissenschaftssprache und Musterhaftigkeit -- 2. Untersuchungsgegenstand ,Wissenschaftssprache' -- 3. Muster und Musterhaftigkeit -- II. Empirischer Teil: Methode, Korpus, Datenauswertung -- 4. Korpuslinguistische Methodologie und Mustererkennung aus statistischer Sicht -- 5. Korpus und methodisches Vorgehen -- 6. Auswertung - das Typikprofil ,wissenschaftlicher Aufsatz' -- III. Theoretische Verortung der Ergebnisse und Fazit -- 7. Theoretische Verortung der Ergebnisse -- 8. Fazit -- Literaturverzeichnis -- Anhang -- Register"]
[null,null,null,"Sommario/riassunto","Die Studie arbeitet den musterhaften Sprachgebrauch in wissenschaftlichen Texten heraus und beschreibt auf der Basis einer datengeleiteten Korpusanalyse den Wissenschaftsstil auf formaler und pragmatischer Ebene. Mit der theoretischen Einbettung in mehrere linguistische Teildisziplinen leistet das Buch einen wichtigen Beitrag zur Textsortenforschung, zur Normendiskussion und zur Schreibforschung."]
[{"$nulls":4},"The study examines patterns of language usage in scientific texts and describes the academic style based on a data-derived corpus analysis at the formal and pragmatic levels. Theoretically grounded in multiple linguistic subdisciplines, the book offers an important contribution to the description of text types, the discussion of norms, and research on "]
[{"$nulls":4},"writing."]