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[null,"1.","Record Nr.",null,"UNINA9910495350303321"]
[null,null,"Titolo",null,"Anoikis : how the extracellular matrix regulates life-or-death decisions / / edited by Steven M. Frisch"]
[null,null,"Pubbl/distr/stampa",null,"Cham, Switzerland : , : Springer, , [2021]"]
[{"$nulls":4},"©2021"]
[null,null,"ISBN",null,"3-030-73856-6"]
[null,null,"Descrizione fisica",null,"1 online resource (210 pages)"]
[null,null,"Disciplina",null,"571.936"]
[null,null,"Soggetti",null,"Extracellular matrix"]
[{"$nulls":4},"Apoptosis"]
[{"$nulls":4},"Apoptosi"]
[{"$nulls":4},"Histologia"]
[{"$nulls":4},"Llibres electrònics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Intro -- Introduction -- Contents -- 1 Metabolic Contributions to Anoikis-Resistance in Metastatic Dissemination -- Abstract -- 1 Introduction -- 2 Bioenergetics -- 2.1 Glycolysis -- 2.2 Glutaminolysis -- 2.3 Autophagy -- 3 Redox Control -- 3.1 Restricted Glucose Oxidation -- 3.2 Antioxidant Defenses -- 3.3 ROS-Mediated Anti-apoptotic Signaling -- 4 Conclusion -- References -- 2 Metabolic Reprogramming and the Control of Anoikis Resistance in Cancer -- Abstract -- 1 Metabolic Signal Integrators -- 1.1 The PI3K/Akt-mTOR Pathway -- 1.2 The Ras-MAPK Pathway -- 1.3 Myc and HIF-1 Transcription Factors -- 1.4 AMPK Pathway -- 2 ECM Attachment-Dependent Signaling Pathways that Regulate Cell Metabolism -- 3 An Overview of Model Systems Used to Study Anoikis -- 4 Metabolic Adaptations of Detached Cancer Cells-Roles in Anoikis-Resistance and Metastasis -- 4.1 Glucose Metabolism -- 4.2 Amino Acid Metabolism -- 4.3 Redox Homeostasis -- 4.3.1 Antioxidant Enzymes in Anoikis-Resistance -- 4.3.2 Mechanisms to Reduce ROS Generation -- 4.3.3 Synthesis of Reducing Equivalents -- 4.3.4 Mitochondrial ROS and Anoikis -- 4.4 Lipid Metabolism -- 5 HIF-1 and Anoikis-Resistance -- 6 Autophagy and Its Role in the Regulation of Metabolic Stress and Anoikis -- 7 Metabolic Switch in Detached Cells-The Tug of War Between AMPK and Akt -- Acknowledgement -- References -- 3 The "]
[{"$nulls":4},"Intersection of Anoikis Resistance and Fatty Acid Metabolism in Cancer -- Abstract -- 1 Introduction -- 2 Metabolic Plasticity -- 3 Fatty Acid Oxidation -- 4 Stemness and Fatty Acid Oxidation -- 5 FAO in Ovarian Cancer -- 6 FAO-Mediated Signaling and Anoikis Resistance -- 7 Receptor Tyrosine Kinase Contribution to Metabolic Reprogramming -- 8 Conclusions -- References -- 4 Shc and the Control of Small GTPase Dynamics in Cellular Anchorage -- Abstract."]
[{"$nulls":4},"1 Cellular Anchorage and the Importance of Shape Change -- 2 Regulation of Shape Change by Rho GTPases -- 3 Rho GTPases and Abnormal Matrix Signaling in Cancer -- 4 p52Shc and the Control of Mechanical Signals -- 5 Distinct Functional Roles for p66Shc -- 6 Control of RhoA and Anoikis by p66Shc -- 7 p66Shc and Metastatic Behavior -- 8 Epigenetic Control of SHC1 and Implications for Lineage Shifting -- 9 Summary -- References -- 5 Anoikis and the Human Gut Epithelium in Health and Disease -- Abstract -- 1 Anoikis: Back to (General) Basics -- 1.1 A Brief Word on Apoptosis -- 1.2 Cell-ECM and Cell-Cell Interactions -- 1.2.1 Integrins -- 1.2.2 E-cadherin -- 1.3 Enter Anoikis -- 1.3.1 Anoikis and Integrins -- 1.3.2 Anoikis and E-cadherin -- 2 Anoikis and the Human Gut Epithelium in Health -- 2.1 Anoikis and the Renewal of the Human Gut Epithelium -- 2.1.1 A Few Words on the Regulation of hIEC Survival -- 2.1.2 hIEC Anoikis: Sensitivity Versus State of Differentiation -- 2.2 hIEC Anoikis and Integrins -- 2.3 hIEC Anoikis and E-cadherin -- 3 Anoikis and the Human Gut Epithelium in Disease -- 3.1 Anoikis and CRC: Generalities -- 3.1.1 Anoikis, Integrins and CRC -- 3.1.2 Anoikis, E-cadherins and CRC -- 3.2 Anoikis and ... IBD? -- 4 Concluding Considerations -- Acknowledgements -- References -- 6 The Roles of Anoikis in Cervical Cancer -- Abstract -- 1 Introduction -- 2 The Role of Anoikis in Cervical Cancer -- 2.1 Molecular Mechanisms of Anoikis -- 2.2 The Role of Anoikis Resistance in Cervical Cancer Invasion and Metastasis -- 2.3 Molecular Mechanisms of Anoikis Resistance in Cervical Cancer Cells -- 2.4 The Role of Chronic Stress in Cervical Cancer Through Anoikis Resistance -- 3 The Role of YAP Proteins in Cervical Cancer -- 3.1 The Structure and Function of YAP-Related Proteins -- 3.2 Role of YAP Proteins in Cervical Caner."]
[{"$nulls":4},"3.3 YAP Proteins in the Susceptibility to hrHPV Infection -- 3.4 The Role of Chronic Stress in Cervical Cancer Through the Hippo-YAP Pathway -- 4 Conclusions and Future Directions -- References -- 7 Anoikis Resistance in Melanoma -- Abstract -- 1 Introduction -- 2 Epithelial-Mesenchymal Transition (EMT) -- 3 Anoikis-Death Induced in Epithelial Cells upon Detachment from Extra Cellular Matrix (ECM) -- 4 General Pathways Leading to Anoikis Resistance in Epithelial Tissues -- 5 Melanocytes and Melanoma-Non-epithelial Lineage Origins -- 6 Cell Surface Molecules in Anoikis Resistance in Melanoma -- 6.1 Integrin Switch -- 6.2 Fibronectin -- 6.3 Cadherins -- 7 Activation of Receptor Tyrosine Kinases in Melanoma Anoikis Resistance -- 7.1 c-MET/HGF Axis -- 7.2 FGFR1/FGF2 Axis -- 8 Signaling Pathways in Melanoma Anoikis Resistance -- 8.1 Mitogen-Activated Protein Kinase (MAPK) Pathway -- 8.2 Phosphoinositide 3-Kinase (PI3K)/AKT Pathway -- 8.3 CDKN2A and p16INK4A -- 8.4 Focal Adhesion Kinase (FAK) Pathway -- 9 Transcription Factors in Melanoma Anoikis Resistance -- 9.1 STAT3 -- 9.2 FOSL1 -- 9.3 BRN2 -- 10 Anti-apoptotic Mechanisms in Melanoma Anoikis Resistance -- 11 Conclusion -- References -- 8 Anoikis Mediated by Stress-Activated MAPK Signaling Pathways -- Abstract -- 1 Stress-Activated MAPK Signaling Pathways -- 1.1 p38 MAPK -- 1.2 JNK -- 2 Stress-Activated MAPK and Cell Death -- 3 Stress-Activated MAPK and BCL2 Family Proteins -- 4 JNK and Anoikis -- 5 p38 MAPK and Anoikis -- 6 Conclusions -- References -- 9 The "]
[{"$nulls":4},"TGFβ and Androgen Receptor Signaling Pathways Converge to Support Anoikis Resistance in Triple Negative Breast Cancer -- Abstract -- 1 Introduction -- 2 Anoikis Resistance and Breast Cancer -- 3 The TGFβ Pathway -- 4 TGFβ Signaling in Breast Cancer -- 5 TGFβ Inhibitors in BC Clinical Trials."]
[{"$nulls":4},"6 Connections Between AR and TGFβ in Prostate and Breast Cancer -- 7 TGFβ and AR Pathways Converge to Support TNBC Anoikis Resistance -- References -- 10 Regulation of Homeostasis and Anoikis by Epithelial Cell Extrusion -- Abstract -- 1 Introduction -- 2 Sphingosine-1-Phosphate (S1P) and Collaborating Factors in Cell Extrusion -- 3 Specialized Mechanisms Pertaining to the Extrusion of Transformed Cells -- 4 Summary and Future Directions -- References."]
[null,"2.","Record Nr.",null,"UNINA9910792102403321"]
[null,null,"Autore",null,"Pitney John J., Jr., <1955->"]
[null,null,"Titolo",null,"Politics of Autism [[electronic resource] ] : Navigating The Contested Spectrum"]
[null,null,"Pubbl/distr/stampa",null,"Rowman & Littlefield Publishers, 2015"]
[null,null,"ISBN",null,"1-4422-4960-9"]
[{"$nulls":4},"1-4422-4961-7"]
[null,null,"Descrizione fisica",null,"1 online resource (191 p.)"]
[null,null,"Disciplina",null,"618.9285"]
[null,null,"Soggetti",null,"Autistic disorder -- United States"]
[{"$nulls":4},"Education, Special -- United States"]
[{"$nulls":4},"Policy Making -- United States"]
[{"$nulls":4},"Politics -- United States"]
[{"$nulls":4},"Social Control, Formal"]
[{"$nulls":4},"Social Control Policies"]
[{"$nulls":4},"Education, Nonprofessional"]
[{"$nulls":4},"Child Development Disorders, Pervasive"]
[{"$nulls":4},"Social Sciences"]
[{"$nulls":4},"Policy"]
[{"$nulls":4},"Health Care Economics and Organizations"]
[{"$nulls":4},"Education"]
[{"$nulls":4},"Mental Disorders Diagnosed in Childhood"]
[{"$nulls":4},"Sociology"]
[{"$nulls":4},"Health Care"]
[{"$nulls":4},"Mental Disorders"]
[{"$nulls":4},"Geography"]
[{"$nulls":4},"Psychology"]
[{"$nulls":4},"Public Policy"]
[{"$nulls":4},"Autistic Disorder"]
[{"$nulls":4},"Education, Special"]
[{"$nulls":4},"Policy Making"]
[{"$nulls":4},"Politics"]
[{"$nulls":4},"Psychiatry"]
[{"$nulls":4},"Health & Biological Sciences"]
[{"$nulls":4},"Psychiatric Disorders, Individual"]
[{"$nulls":4},"North America"]
[{"$nulls":4},"Americas"]
[{"$nulls":4},"Geographic Locations"]
[{"$nulls":4},"United States"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,"Nota di contenuto",null,"\"\"Contents\"\"; \"\"Preface\"\"; \"\"1 Introduction\"\"; \"\"2 A Short History of Autism\"\"; \"\"3 Medicine, Science, and Math\"\"; \"\"4 Education\"\"; \"\"5 Before, Outside, and After the Classroom\"\"; \"\"6 The Future\"\"; \"\"Appendix: A Timeline of Autism Policy and Politics\"\"; \"\"Notes\"\"; \"\"Index\"\"; \"\"About the Author\"\""]
[null,null,null,"Sommario/riassunto","In the first book devoted exclusively to the contentious politics of autism, noted political scientist and public policy expert John J. Pitney, Jr., explains how autism has evolved into a heated political issue disputed by scientists, educators, social workers, and families. Nearly everything about autism is subject to debate and struggle, including its measurement and definition. Organizational attempts to deal with autism have resulted in not a single \"autism policy,\" but a vast array of policies at the federal, state, and local levels, which often leave people with autism and their families"]
[null,"3.","Record Nr.",null,"UNINA9910792578003321"]
[null,null,"Titolo",null,"Renaissance theories of vision / / edited by John Shannon Hendrix and Charles H. Carman"]
[null,null,"Pubbl/distr/stampa",null,"London ; ; New York : , : Routledge, , 2016"]
[null,null,"ISBN",null,"1-4094-2399-9"]
[{"$nulls":4},"1-317-06639-1"]
[{"$nulls":4},"9786612892752"]
[{"$nulls":4},"1-315-60531-7"]
[{"$nulls":4},"1-282-89275-4"]
[{"$nulls":4},"1-4094-0024-7"]
[null,null,"Descrizione fisica",null,"1 online resource (258 pages) : illustrations"]
[null,null,"Collana",null,"Visual Culture in Early Modernity"]
[null,null,"Disciplina",null,"701.8"]
[null,null,"Soggetti",null,"Visual perception - History"]
[{"$nulls":4},"Vision - History"]
[{"$nulls":4},"Perspective - History"]
[{"$nulls":4},"Art - Philosophy"]
[{"$nulls":4},"Art, Renaissance"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","\"An Ashgate book\"--Cover."]
[{"$nulls":4},"First published 2010 by Ashgate Publishing."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Introduction / John S. Hendrix and Charles H. Carman -- Classical optics and the perspectivae traditions leading to the Renaissance / Nader El-Bizri -- Meanings of perspective in the Renaissance : tensions and resolution / Charles Carman -- Criminal vision in early modern Florence : Fra Angelico's altarpiece for \"Il Tempio\" and the Magdalenian gaze / Allie Terry -- Donatello's Chellini Madonna, light, and vision / Amy R. Bloch -- Perception as a function of desire in the Renaissance / John Hendrix -- Leonardo da Vinci's theory of vision and creativity : the Uffizi Annunciation / Liana De Girolami Cheney -- At the boundaries of sight : the Italian Renaissance cloud putto / Christian Kleinbub -- Gesture and perspective in Raphael's School of Athens / Nicholas Temple -- Seeing and the transfer of spirits in early modern art theory / Thijs Weststeijn -- \"All in him selfe as in a glass he sees\" : mirrors and vision in the Renaissance / Faye Tudor -- \"Nearest the tangible earth\" : Rembrandt, Samuel van Hoogstraten, George Berkeley, and the "]
[{"$nulls":4},"optics of touch / Alice Crawford Berghof."]
[null,null,null,"Sommario/riassunto","How are processes of vision, perception, and sensation conceived in the Renaissance? How are those conceptions made manifest in the arts? The essays in this volume address these and similar questions to establish important theoretical and philosophical bases for artistic production in the Renaissance and beyond. The essays also attend to the views of historically significant writers from the ancient classical period to the eighteenth century, including Plato, Aristotle, Plotinus, St Augustine, Ibn Sina (Avicenna), Ibn al-Haytham (Alhazen), Ibn Sahl, Marsilio Ficino, Nicholas of Cusa, Leon Battista Alberti, Gian Paolo Lomazzo, Gregorio Comanini, John Davies, Rene Descartes, Samuel van Hoogstraten, and George Berkeley."]
[null,"4.","Record Nr.",null,"UNINA9910254088203321"]
[null,null,"Autore",null,"Kreuzer Martin"]
[null,null,"Titolo",null,"Computational Linear and Commutative Algebra / / by Martin Kreuzer, Lorenzo Robbiano"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016"]
[null,null,"ISBN",null,"3-319-43601-5"]
[null,null,"Edizione",null,"[1st ed. 2016.]"]
[null,null,"Descrizione fisica",null,"1 online resource (XVIII, 321 p. 1 illus.)"]
[null,null,"Disciplina",null,"512.24"]
[null,null,"Soggetti",null,"Commutative algebra"]
[{"$nulls":4},"Commutative rings"]
[{"$nulls":4},"Matrix theory"]
[{"$nulls":4},"Algebra"]
[{"$nulls":4},"Commutative Rings and Algebras"]
[{"$nulls":4},"Linear and Multilinear Algebras, Matrix Theory"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Foreword -- Introduction -- 1 Endomorphisms -- 2 Families of Commuting Endomorphisms -- 3 Special Families of Endomorphisms -- 4 Zero-Dimensional Affine Algebras -- 5 Computing Primary and Maximal Components -- 6 Solving Zero-Dimensional Polynomial Systems -- Notation -- References -- Index."]
[null,null,null,"Sommario/riassunto","This book combines, in a novel and general way, an extensive development of the theory of families of commuting matrices with applications to zero-dimensional commutative rings, primary decompositions and polynomial system solving. It integrates the Linear Algebra of the Third Millennium, developed exclusively here, with classical algorithmic and algebraic techniques. Even the experienced reader will be pleasantly surprised to discover new and unexpected aspects in a variety of subjects including eigenvalues and eigenspaces of linear maps, joint eigenspaces of commuting families of endomorphisms, multiplication maps of zero-dimensional affine algebras, computation of primary decompositions and maximal ideals, and solution of polynomial systems. This book completes a trilogy initiated by the uncharacteristically witty books Computational Commutative Algebra 1 and 2 by the same authors. The material treated here is not available in book form, and much of it is not "]
[{"$nulls":4},"available at all. The authors continue to present it in their lively and humorous style, interspersing core content with funny quotations and tongue-in-cheek explanations."]