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[null,"1.","Record Nr.",null,"UNINA9910138410903321"]
[null,null,"Autore",null,"Rupp Carriveau"]
[null,null,"Titolo",null,"Fundamental and Advanced Topics in Wind Power / / edited by Rupp Carriveau"]
[null,null,"Pubbl/distr/stampa",null,"IntechOpen, 2011"]
[{"$nulls":4},"Rijeka, Croatia : , : IntechOpen, , 2011"]
[{"$nulls":4},"©2011"]
[null,null,"ISBN",null,"953-51-4491-X"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (436 pages) : illustrations"]
[null,null,"Disciplina",null,"621.312136"]
[null,null,"Soggetti",null,"Wind Power"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","As the fastest growing source of energy in the world, wind has a very important role to play in the global energy mix. This text covers a spectrum of leading edge topics critical to the rapidly evolving wind power industry. The reader is introduced to the fundamentals of wind energy aerodynamics; then essential structural, mechanical, and electrical subjects are discussed. The book is composed of three sections that include the Aerodynamics and Environmental Loading of Wind Turbines, Structural and Electromechanical Elements of Wind Power Conversion, and Wind Turbine Control and System Integration. In addition to the fundamental rudiments illustrated, the reader will be exposed to specialized applied and advanced topics including magnetic suspension bearing systems, structural health monitoring, and the optimized integration of wind power into micro and smart grids."]
[null,"2.","Record Nr.",null,"UNINA9910227348003321"]
[null,null,"Autore",null,"Wilfredo Mellado"]
[null,null,"Titolo",null,"Myelin-Mediated Inhibition of Axonal Regeneration: Past, Present, and Future"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2017"]
[null,null,"Descrizione fisica",null,"1 online resource (116 p.)"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[null,null,"Soggetti",null,"Neurosciences"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Pioneering studies conducted in the 1980's laid the foundation for the hypothesis that axonal regeneration is limited by CNS myelin, and the identification of myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte myelin glycoprotein (OMgp) as inhibitors of neurite outgrowth firmly established myelin as a key factor in regenerative failure. Mechanistically, it has been shown that MAG, Nogo, and OMgp mediate inhibition by binding to either Nogo receptor (NgR) or paired immunoglobulin receptor B (PirB), and initiating a signaling cascade that culminates in the activation of RhoA. Since the discovery of these proteins, there has been tremendous interest in identifying compounds and molecular mechanisms that are capable of overcoming myelin-mediated inhibition. Many studies have focused on pharmacological antagonism of receptors and signaling intermediates, while others have sought to identify and enhance endogenous pro-regenerative pathways. The most notable example of the latter is the conditioning lesion effect, which led to the discovery of cyclic AMP's ability to overcome inhibition by MAG and myelin. Many of the agents tested in these studies have been shown to promote axonal regeneration in vivo, and this research topic allows researchers to share information about new treatments that have been developed in both academia and industry. As we look toward the future, it is becoming increasingly clear that reversal of myelin-mediated inhibition alone will not be sufficient to produce functional recovery from spinal cord injury, and that other factors, such as astroglial scarring, the expression of chondroitin sulfate proteoglycans, neuronal cell death, and lack of neurotrophic "]
[{"$nulls":4},"support, must also be taken into consideration. Combinatorial approaches therefore hold a great deal of promise, and we hope to initiate a dialogue on how stem cell transplantation, chondroitinase ABC, gene therapy, growth-promoting agents, and other methods can be combined to optimize functional recovery. We introduce this topic in honor of the life and work of Dr. Marie T. Filbin (1955-2014). Through these articles, we highlight past achievements in the field, novel findings, unanswered questions and innovative ideas that we hope will lead to new advances in axonal regeneration."]