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[null,"1.","Record Nr.",null,"UNINA9910784251903321"]
[null,null,"Titolo",null,"Virtual ADMET assessment in target selection and maturation [[electronic resource] /] / edited by B. Testa and L. Turski"]
[null,null,"Pubbl/distr/stampa",null,"Amsterdam ; ; Washington, DC, : IOS Press, c2006"]
[null,null,"ISBN",null,"1-280-81056-4"]
[{"$nulls":4},"9786610810567"]
[{"$nulls":4},"1-4294-6772-X"]
[{"$nulls":4},"1-60750-219-4"]
[{"$nulls":4},"600-00-0604-7"]
[{"$nulls":4},"1-4337-0155-3"]
[null,null,"Descrizione fisica",null,"1 online resource (268 p.)"]
[null,null,"Collana",null,"Solvay Pharmaceuticals Conferences ; ; v. 6"]
[null,null,"Disciplina",null,"615/.190285"]
[null,null,"Soggetti",null,"Drug development - Computer simulation"]
[{"$nulls":4},"Pharmacology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Organized May 11-13th, 2005 in Lucerne, Switzerland."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Preface; List of Contributors; Contents; Conference Preface; The Risky Business of Developing Drugs; Benefits and Limits of in Silico Predictions; Musings on ADME Predictions and Molecular Structure; Lipophilicity: Its Calculation and Application in ADMET Predictions; Interpretation of the Role of the Electrotopological State and Molecular Connectivity Indices in the Prediction of Physical Properties and ADME-Tox Behavior - Case Study: Human Plasma Protein Binding; Molecular Descriptors for Predicting ADMET Properties; Molecular Fields to Assess Recognition Forces and Property Spaces"]
[{"$nulls":4},"Extracting Pharmacophores from Bio-Active MoleculesIn Silico Models for Human Bioavailability; In Silico Models to Predict Brain Uptake; Algorithms to Predict Affinity for Transporters; Predicting Affinity for and Metabolism by Cytochromes P450; Expert Systems to Predict Biotransformation; Expert Systems to Predict Toxicity; From in Vivo to in Vitro/in Silico ADME: Progress and Challenges; Author Index"]
[null,null,null,"Sommario/riassunto","Today, biologists and medicinal chemists realize that there is a strong relationship between pharmacodynamic (what the drug does to the organism) and pharmacokinetic (what the organism does to the drug) effects. A significant contributing factor to the evolution in drug discovery was the methodological and technological revolution with the "]
[{"$nulls":4},"advent of combinatorial chemistry, high-throughput screening and profiling, and in silico prediction of target-based activity and ADMET (absorption, distribution, metabolism, excretion and toxicity) properties. High-throughput screening and in silico methods"]
[null,"2.","Record Nr.",null,"UNISANNIOPUV0220569"]
[null,null,"Titolo",null,"Network models / edited by M. O. Ball ... [et al.]"]
[null,null,"Pubbl/distr/stampa",null,"Amsterdam [etc.], : Elsevier, 1995"]
[null,null,"ISBN",null,"0444892923"]
[null,null,"Descrizione fisica",null,"XII, 786 p. ; 25 cm."]
[null,null,"Collana",null,"Handbooks in operations research and management science ; 7"]
[null,null,"Disciplina",null,"658.4"]
[{"$nulls":4},"658.4032"]
[null,null,"Soggetti",null,"Ottimizzazione <matematica>"]
[{"$nulls":4},"Aziende - Gestione - Controllo"]
[null,null,"Collocazione",null,"SALA DING 658.4                   NETM"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,"3.","Record Nr.",null,"UNINA9910220115503321"]
[null,null,"Autore",null,"Acosta Joie D."]
[null,null,"Titolo",null,"Mental health stigma in the military / / Joie D. Acosta [et al.]"]
[null,null,"Pubbl/distr/stampa",null,"RAND Corporation, 2014"]
[{"$nulls":4},"Santa Monica, CA : , : Rand ; , 2014"]
[null,null,"ISBN",null,"0-8330-8999-4"]
[null,null,"Descrizione fisica",null,"1 online resource (xxxii, 296 pages) : illustrations"]
[null,null,"Disciplina",null,"362.2088/35500973"]
[null,null,"Soggetti",null,"Soldiers - Mental health services - Evaluation - United States"]
[{"$nulls":4},"Stigma (Social psychology) - United States"]
[{"$nulls":4},"Mental health policy - United States"]
[{"$nulls":4},"Mental Health Services - standards"]
[{"$nulls":4},"Military Personnel - psychology"]
[{"$nulls":4},"United States Mental health services Evaluation"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[{"$nulls":4},"\"RR-426-OSD\"--Page 4 of cover"]
[null,null,"Nota di contenuto",null,"Introduction Defining Stigma in the Military Context Prevalence of Mental Health Stigma in the Military Societal Costs of Mental Health Stigma in the Military Promising Programmatic and Policy Approaches to Reducing Stigma U.S. Department of Defense Programs to Reduce Mental Health Stigma U.S. Department of Defense Policies Related to Stigma Key Findings and Priorities for Improving the U.S. Department of Defense's Approach to Stigma Reduction Appendix A: Methods for Literature Review Appendix B: Definitions of Mental Health Stigma Appendix C: Prevalence of Stigma in the General U.S. Population Appendix D: Detailed Methods for the Modeling Approach Appendix E: Program Descriptions and Analysis Appendix F: Policy-Analysis Methods Appendix G: Policies with Implications for Stigma Appendix H: Policies That Contain Negative Terminology with Implications for Stigma Appendix I: Methods Used to Conduct the Expert Panel to Refine and Vet Priorities for Mental Health Stigma Reduction in the U.S. Department of Defense"]
[null,null,null,"Sommario/riassunto","Despite the efforts of both the U.S. Department of Defense and the Veterans Health Administration to enhance mental health services, many service members are not regularly seeking needed care when "]
[{"$nulls":4},"they have mental health problems. Without appropriate treatment, these mental health problems can have wide-ranging and negative impacts on the quality of life and the social, emotional, and cognitive functioning of affected service members. The services have been actively engaged in developing policies, programs, and campaigns designed to reduce stigma and increase service members' help-seeking behavior. However, there has been no comprehensive assessment of these efforts' effectiveness and the extent to which they align with service members' needs or evidence-based practices. The goal of this research was to assess DoD's approach to stigma reduction, how well it is working and how it might be improved. To address these questions, RAND researchers used five complementary methods: (1) literature review, (2) a microsimulation modeling of costs, (3) interviews with program staff, (4) prospective policy analysis, and (5) an expert panel. The priorities outlined in this report identify ways in which program and policy development and research and evaluation can improve understanding of how best to efficiently and effectively provide needed treatment to service members with mental illness."]