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[null,"1.","Record Nr.",null,"UNINA9910220052803321"]
[null,null,"Autore",null,"Vittorio Venturi"]
[null,null,"Titolo",null,"LuxR Solos are Becoming Major Players in Cell-Cell Communication in Bacteria"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2016"]
[null,null,"Descrizione fisica",null,"1 online resource (122 p.)"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[null,null,"Soggetti",null,"Biology, life sciences"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","The most common quorum sensing (QS) system in Gram-negative bacteria occurs via N-acyl homoserine lactone (AHLs) signals. An archetypical system consists of a LuxI-family protein synthesizing the AHL signal which binds at quorum concentrations to the cognate LuxR-family transcription factors which then control gene expression by binding to specific sequences in target gene promoters. QS LuxR-family proteins are approximately 250 amino acids long and made up of two domains; at the N-terminus there is an autoinducer-binding domain whereas the C-terminus contains a DNA-binding helix-turn-helix (HTH) domain. QS LuxRs display surprisingly low similarities (18-25%) even if they respond to structurally similar AHLs. 95% of LuxRs share 9 highly conserved amino acid residues; six of these are hydrophobic or aromatic and form the cavity of the AHL-binding domain and the remaining three are in the HTH domain. With only very few exceptions, the luxI/R cognate genes of AHL QS systems are located adjacent to each other. The sequencing of many bacterial genomes has revealed that many proteobacteria also possess LuxRs that do not have a cognate LuxI protein associated with them. These LuxRs have been called orphans and more recently solos. LuxR solos are widespread in proteobacterial species that possess a canonical complete AHL QS system as well as in species that do not. In many cases more than one LuxR solo is present in a bacterial genome. Scientists are beginning to investigate these solos. Are solos responding to AHL signals? If present in a bacterium which possesses a canonical AHL QS system are solos an integral part of the regulatory "]
[{"$nulls":4},"circuit? Are LuxR solos eavesdropping on AHLs produced by neighboring bacteria? Have they evolved to respond to different signals instead of AHLs, and are these signals endogenously produced or exogenously provided? Are they involved in interkingdom signaling by responding to eukaryotic signals? Recent studies have revealed that LuxR solos are involved in several mechanisms of cell-cell communication in bacteria implicating them in bacterial intraspecies and interspecies communication as well as in interkingdom signaling by responding to molecules produced by eukaryotes. LuxR solos are likely to become major players in signaling since they are widespread among proteobacterial genomes and because initial studies highlight their different roles in bacterial communication. This Research Topic allows scientists studying or interested in LuxR solos to report their data and/or express their hypotheses and thoughts on this important and currently understudied family of signaling proteins."]
[null,"2.","Record Nr.",null,"UNINA9910754088303321"]
[null,null,"Autore",null,"Roman Sanziana A"]
[null,null,"Titolo",null,"Controversies in Thyroid Nodules and Differentiated Thyroid Cancer : A Case-Based Approach / / edited by Sanziana A. Roman, Wen T. Shen, Julie Ann Sosa"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2023"]
[null,null,"ISBN",null,"3-031-37135-6"]
[null,null,"Edizione",null,"[1st ed. 2023.]"]
[null,null,"Descrizione fisica",null,"1 online resource (211 pages)"]
[null,null,"Disciplina",null,"616.44"]
[null,null,"Soggetti",null,"Oncology"]
[{"$nulls":4},"Surgery"]
[{"$nulls":4},"Otolaryngology"]
[{"$nulls":4},"Otorhinolaryngology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Chapter 01: Incidence and Epidemiology of Differentiated Thyroid Cancer: Is thyroid cancer incidence truly increasing, or is it simply a finder effect? -- Chapter 02: Criteria for Fine-Needle Aspiration Biopsy in Thyroid Nodules -- Chapter 03: Preoperative Molecular Testing for Indeterminate Thyroid Nodules -- Chapter 04: Active Surveillance of Low-Risk Differentiated Thyroid Cancer -- Chapter 05: Preoperative Laryngoscopy in Thyroid Surgery Patients -- Chapter 06: Radiofrequency Ablation for Thyroid Nodules -- Chapter 07: Management of low-risk papillary thyroid cancer in a patient with familial non-medullary thyroid cancer -- Chapter 08: Intraoperative Nerve Monitoring in Thyroid Operations -- Chapter 09: Extent of Surgery for Low-Risk Papillary Thyroid Cancer -- Chapter 10: Surgical Management of Locally Advanced Thyroid Cancer with Tracheal Invasion -- Chapter 11: Management of Central Neck Nodes in Papillary Thyroid Cancer -- Chapter 12: Impact of Surgeon Volume in Thyroid Operations -- Chapter 13: Intraoperative/Postoperative Calcium Management in Thyroidectomy -- Chapter 14: Indications for Radioactive Iodine Therapy in Thyroid Cancer Patients -- Chapter 15: Recurrent Nodal Metastases of Papillary Thyroid Cancer -- Chapter 16: Management of Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Features (NIFT-P) -- Chapter 17: Timing of long-term post-operative surveillance for low-risk differentiated thyroid cancer -- "]
[{"$nulls":4},"Chapter 18: External-Beam Radiation for Patients with Differentiated Thyroid Cancer – Is There a Role?"]
[null,null,null,"Sommario/riassunto","This book provides a practical, evidence-based approach to controversies in the management of thyroid nodules and differentiated thyroid cancer (DTC). Thyroid nodules are a commonly encountered clinical entity, identified in 2-6% of the population by palpation, and 20-35% by ultrasound. DTC is the solid organ cancer with the most rapidly increasing incidence (more than 50,000 new cases in the U.S. annually). Despite extensive research and multiple published comprehensive practice guidelines, numerous controversies remain within this field covering a wide range of issues, including incidence and epidemiology, radiographic evaluation, criteria for needle biopsy, cytopathologic and molecular diagnostics, active surveillance vs. operation for low-risk tumors, extent of surgery, indications for radioactive iodine treatment and external beam radiation, and optimal protocols for follow-up. The book takes a case-based approach: each chapter begins with a patient presentation highlighting a particular controversial subject in thyroid nodules and DTC. The remainder of each chapter discusses the controversy within the context of current scientific understanding and clinical practice, using the latest evidence-based practice guidelines. Chapters conclude with a final review and discussion of the opening case, with options and recommendations for next steps provided. The recommendations are evidence-based and practical, intended to help guide practitioners in their ongoing care of patients with thyroid nodules and DTC. Each chapter was written by a recognized expert in the area of controversy, including endocrine surgeons, endocrinologists, radiologists, medical oncologists, and nuclear medicine specialists. Controversies in Thyroid Nodules and Differentiated Thyroid Cancer: A Case-Based Approach is an excellent guide for oncologists, endocrinologists, otorhinolaryngologists, surgeons, and practitioners of all types that care for patients with thyroid nodulesand DTC."]