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[null,"1.","Record Nr.",null,"UNINA9910164341503321"]
[null,null,"Autore",null,"Tveito Aslak"]
[null,null,"Titolo",null,"Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models [[electronic resource] /] / by Aslak Tveito, Glenn T. Lines"]
[null,null,"Pubbl/distr/stampa",null,"Basingstoke, : Springer Nature, 2015"]
[{"$nulls":4},"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2016"]
[null,null,"ISBN",null,"3-319-30030-X"]
[null,null,"Edizione",null,"[1st ed. 2016.]"]
[null,null,"Descrizione fisica",null,"1 online resource (XVI, 261 p. 129 illus., 30 illus. in color.)"]
[null,null,"Collana",null,"Lecture Notes in Computational Science and Engineering, , 1439-7358 ; ; 111"]
[null,null,"Disciplina",null,"004"]
[null,null,"Soggetti",null,"Computer mathematics"]
[{"$nulls":4},"Medicine"]
[{"$nulls":4},"Optical data processing"]
[{"$nulls":4},"Computational Science and Engineering"]
[{"$nulls":4},"Biomedicine, general"]
[{"$nulls":4},"Computer Imaging, Vision, Pattern Recognition and Graphics"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,"Nota di contenuto",null,"Preface -- Background: Contents and Method -- One-dimensional calcium release -- Models of open and state blockers -- Two-dimensional calcium release -- Computing theoretical drugs in the two-dimensional case -- Generalized systems -- Calcium-induced calcium release -- Numerical release for CICR -- A prototypical model of an ion channel -- Inactivated ion channels -- A simple model of the sodium channel -- Mutations affecting the mean open time -- The burst mode -- Whole sale action potentials -- ."]
[null,null,null,"Sommario/riassunto","Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. "]
[{"$nulls":4},"Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model."]
[null,"2.","Record Nr.",null,"UNINA9910842300003321"]
[null,null,"Autore",null,"Pherson Randolph H."]
[null,null,"Titolo",null,"Clear Thinking : Structured Analytic Techniques and Strategic Foresight Analysis for Decisionmakers / / by Randolph H. Pherson, Ole Donner, Oliver Gnad"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2024"]
[null,null,"ISBN",null,"3-031-48766-4"]
[null,null,"Edizione",null,"[1st ed. 2024.]"]
[null,null,"Descrizione fisica",null,"1 online resource (259 pages)"]
[null,null,"Collana",null,"Professional Practice in Governance and Public Organizations, , 2731-9784"]
[null,null,"Disciplina",null,"153.83"]
[null,null,"Soggetti",null,"Security, International"]
[{"$nulls":4},"Political science"]
[{"$nulls":4},"Cognitive psychology"]
[{"$nulls":4},"Political leadership"]
[{"$nulls":4},"World politics"]
[{"$nulls":4},"International Security Studies"]
[{"$nulls":4},"Governance and Government"]
[{"$nulls":4},"Cognitive Psychology"]
[{"$nulls":4},"Political Leadership"]
[{"$nulls":4},"Political History"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Chapter 1. Setting the Stage -- Chapter 2. Understanding How We Think: System I and System 2 -- Chapter 3. Conceptualizing Your Topic -- Chapter 4. Blackout In Berlin! -- Chapter 5. Terror in Stockholm -- Chapter 6. Conflict or Cooperation in the Arctic? -- Chapter 7. Optimizing the Impact of Your Product -- Chapter 8. Outlook."]
[null,null,null,"Sommario/riassunto","This book enables analysts in government and the private sector as well as policy advisors and decision makers to assess global risks and opportunities systematically, make well-founded and informed decisions, and anticipate the unanticipated. The authors illuminate the basics of intuitive and analytical thinking and how structured techniques can mitigate the impact of cognitive biases, misapplied heuristics, and intuitive traps. Three case studies illustrate how to apply over 30 Structured Analytic Techniques (SATs) with step-by-step instructions. The final chapter focuses on how to optimize the impact "]
[{"$nulls":4},"of your analytic product, be it a paper, briefing, or digital display."]