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[null,"1.","Record Nr.",null,"UNINA9910162994003321"]
[null,null,"Titolo",null,"Skin barrier function / / volume editor, Tove Agner"]
[null,null,"Pubbl/distr/stampa",null,"Basel ; ; New York : , : Karger, , 2016"]
[null,null,"ISBN",null,"3-318-05586-7"]
[null,null,"Descrizione fisica",null,"1 online resource (172 p.)"]
[null,null,"Collana",null,"Current problems in dermatology, , 1421-5721 ; ; volume 49"]
[null,null,"Disciplina",null,"612.7/9"]
[null,null,"Soggetti",null,"Skin - Physiology"]
[{"$nulls":4},"Epidermis - Physiology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and indexes."]
[null,null,"Nota di contenuto",null,"Cover; Front Matter; Contents; Preface; Section I: Basic Parameters; Filaggrin and Skin Barrier Function; Abstract; Filaggrin and the Skin Barrier; Clinical Studies; In vitro Models; Animal Models; Conclusion; Acknowledgment; References; Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients; Abstract; Lipid Properties in Healthy Stratum Corneum; Lipid Properties in Atopic Dermatitis; Enzymes Involved in Lipid Biosynthesis; Effect of FLG Mutations on Lipid Barrier Properties; Natural Moisturizing Factor and pH Levels"]
[{"$nulls":4},"Effect of Inflammation on the Lipid Metabolism and Lipid Barrier PropertiesConcluding Remarks; References; Importance of Tight Junctions in Relation to Skin Barrier Function; Abstract; Tight Junctions and Their Proteins in Mammalian Skin; Barrier Function of Tight Junctions in the Skin; Nonbarrier Functions of Tight Junction Proteins in the Skin; Interaction of Tight Junctions with Other Barriers of the Skin - Importance of Tight Junctions for Skin Barrier Function; Tight Junctions as a Boundary between Microbial and Immunological Barriers; Conclusion; Acknowledgments; References"]
[{"$nulls":4},"Antimicrobial Peptides, Infections and the Skin BarrierAbstract; Antimicrobial Peptides in the Epidermis; Antimicrobial Peptides and Impaired Barrier Function; Antimicrobial Peptides and Infections; Conclusion; Acknowledgment; References; Biological Variation in Skin Barrier Function: From A (Atopic Dermatitis) to X (Xerosis); Abstract; Biological Variation of the Skin Barrier with Age; Pathological Variations in Skin Barrier Function; Conclusion; References; Section II: External Factors Influencing Skin Barrier; Methods for the Assessment of Barrier "]
[{"$nulls":4},"Function; Abstract"]
[{"$nulls":4},"Transepidermal Water LossBioengineering Methods for Skin Barrier Assessment (Other than Transepidermal Water Loss); Tape Stripping and Other Invasive Methods; Spectroscopic Methods, Molecular Imaging and Further Modern Methods; Irritants: Methods Used for Challenging Barrier Function; Conclusion; References; In vivo Raman Confocal Spectroscopy in the Investigation of the Skin Barrier; Abstract; Physical Basis of Raman Spectroscopy; In vivo Raman Confocal Spectroscopy of the Epidermal Barrier; Conclusion; References; Irritants and Skin Barrier Function; Abstract"]
[{"$nulls":4},"Irritants and Skin Barrier HomeostasisNon-Invasive Bioengineering Methods; Conclusions; References; Skin Barrier Function and Allergens; Abstract; Normal Skin Barrier Function; Psoriasis; Atopic Dermatitis; Irritant Contact Dermatitis; Conclusion; Acknowledgment; References; Penetration through the Skin Barrier; Abstract; Percutaneous Penetration; Methodologies for Studying Percutaneous Penetration; Biological Factors Affecting Percutaneous Penetration; Physicochemical Characteristics Affecting Percutaneous Penetration; The Best Experimental Model?; References"]
[{"$nulls":4},"Section III: Optimizing Skin Barrier Function"]
[null,null,null,"Sommario/riassunto","Although a very fragile structure, the skin barrier is probably one of the most important organs of the body. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available.    This book is an interdisciplinary update offering a wide range of information on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier.    Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information."]