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[null,"1.","Record Nr.",null,"UNINA9910161649203321"]
[null,null,"Autore",null,"Shane A. Liddelow"]
[null,null,"Titolo",null,"Ontogeny and Phylogeny of Brain Barrier Mechanisms"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2016"]
[null,null,"Descrizione fisica",null,"1 online resource (358 p.)"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[null,null,"Soggetti",null,"Neurosciences"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","The brain functions within an internal environment that is determined and controlled by morphological structures and cellular mechanisms present at interfaces between the brain and the rest of the body. In vertebrates these interfaces are across cerebral blood vessels (blood-brain barrier) choroid plexuses (blood-cerebrospinal fluid barrier) and pia-arachnoid. There is a CSF-brain barrier in the neuroepithelium lining the ventricular system that is only present in embryos. There is now substantial evidence that many brain barrier mechanisms develop early and that in some cases they are functionally more active and even more specialized compared to adult barriers. Therefore barriers in developing brain should be viewed as adapted appropriately for the growing brain and not, as is still widely believed, immature. Considerable advances in our understanding of these barrier mechanisms have come from studies of the developing brain and invertebrates. A striking aspect, to be highlighted in this special edition, is that many of the molecular mechanisms in these very diverse species are similar despite differences in the cellular composition of the interfaces. This Frontiers Topic comprises articles in three sections: Original studies, Reviews and Myths & Misconceptions. Original articles provide new information on molecular and cellular barrier mechanisms in developing brains of primates, including human embryos (Brøchner et al., Ek et al., Errede et al.), rodents (Bauer et al., Liddelow, Strazielle & Ghersi-Egea, Saunders et al., Whish et al.), chick (Bueno et al.) and zebrafish (Henson et al.) as well as studies in drosophila (Hindle & Bainton, De Salvo et al., Limmer et al.). The Reviews section includes evolutionary perspectives of the blood-brain and blood-CSF barriers "]
[{"$nulls":4},"(Bueno et al., Bill & Korzh). There are also detailed reviews of the current state of understanding of different interfaces and their functional mechanisms in developing brain (Bauer et al., Strazielle & Gjersi-Egea, Liddelow, Richardson et al., Errede et al., Henson et al., Brøchner et al.) and in invertebrates (Hindle & Bainton, De Salvo et al., Limmer et al). Different aspects of the relationship between properties of the internal environment of the brain and its development are discussed. (Stolp & Molnar, Johansson, Prasongchean et al.). A neglected area, namely barriers over the surface of the brain during development is also covered (Brøchner et al.). Clinically related perspectives on barrier disruption in neonatal stroke are provided by Kratzer et al. and other aspects of dysfunction by Morretti et al. and by Palmeta et al. on the continuing problem of bilirubin toxicity. Progress in this field is hampered by many prevailing myths about barrier function, combined with methodologies that are not always appropriately selected or interpreted. These are covered in the Misconceptions, Myths and Methods section, including historical aspects and discussion of the paracellular pathway, a central dogma of epithelial and endothelial biology (Saunders et al.) and a review of markers used to define brain barrier integrity in development and in pathological conditions (Saunders et al.). Use of inappropriate markers has caused considerable confusion and unreliable interpretation in many published studies. Torbett et al. deal with the complexities of the new field of applying proteomics to understanding blood-brain barrier properties as do Huntley at al. with respect to applying modern high throughput gene expression methods (Huntley et al.). The Editorial summarizes the contributions from all authors. This includes mention of some the main unanswered but answerable questions in the field and what the impediments to progress may be."]
[null,"2.","Record Nr.",null,"UNINA9910483445903321"]
[null,null,"Titolo",null,"Algorithms and Complexity : 9th International Conference, CIAC 2015, Paris, France, May 20-22, 2015. Proceedings / / edited by Vangelis Th. Paschos, Peter Widmayer"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2015"]
[null,null,"ISBN",null,"3-319-18173-4"]
[null,null,"Edizione",null,"[1st ed. 2015.]"]
[null,null,"Descrizione fisica",null,"1 online resource (XV, 430 p. 81 illus.)"]
[null,null,"Collana",null,"Theoretical Computer Science and General Issues, , 2512-2029 ; ; 9079"]
[null,null,"Disciplina",null,"005.1"]
[null,null,"Soggetti",null,"Algorithms"]
[{"$nulls":4},"Computer science - Mathematics"]
[{"$nulls":4},"Discrete mathematics"]
[{"$nulls":4},"Artificial intelligence - Data processing"]
[{"$nulls":4},"Discrete Mathematics in Computer Science"]
[{"$nulls":4},"Data Science"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Includes index."]
[null,null,"Nota di contenuto",null,"Communication, Dynamics and Renormalization -- Fast and Powerful Hashing using Tabulation -- Green Barrier Coverage with Mobile Sensors -- A Reﬁned Complexity Analysis of Finding the Most Vital Edges for Undirected Shortest Paths -- Orthogonal Graph Drawing with Inﬂexible Edges -- Linear time Constructions of some d-Restriction Problems -- Eﬃciently Testing T-Interval Connectivity in Dynamic Graphs -- Competitive Strategies for Online Clique Clustering -- Scheduling with Gaps: New Models and Algorithms -- MinMax-Distance Gathering on given Meeting Points -- Evacuating Robots from a Disk Using Face-to-Face Communication -- Planarity of Streamed Graphs -- Clique-width of Graph Classes Deﬁned by Two Forbidden Induced Subgraphs -- Randomized Adaptive Test Cover -- Contraction Blockers for Graphs with Forbidden Induced Paths -- Label Placement in Road Maps -- Discrete Stochastic Submodular Maximization: Adaptive vs. Non-Adaptive vs. Oﬄine -- Parameterized Algorithms and Kernels for 3-Hitting Set with Parity Constraints -- Simple strategies versus optimal schedules in multi-agent patrolling -- Sharing Non-Anonymous Costs of Multiple Resources Optimally -- Algorithms solving the Matching Cut problem -- End-Vertices of Graph Search "]
[{"$nulls":4},"Algorithms -- Deciding the On-line Chromatic Number of a Graph with Pre-coloring is PSPACE-complete -- A Lex-BFS-based recognition algorithm for Robinsonian matrices -- Mixed Map Labeling -- Optimal Online Edge Coloring of Planar Graphs with Advice -- Approximability of Two Variants of Multiple Knapsack -- Block Sorting is Hard -- An opportunistic text indexing structure based on run length encoding -- PSPACE-completeness of Bloxorz and of Games with 2-Buttons -- Advice Complexity of Fine-Grained Job Shop Scheduling."]
[null,null,null,"Sommario/riassunto","This book constitutes the refereed conference proceedings of the 9th International Conference on Algorithms and Complexity, CIAC 2015, held in Paris, France, in May 2015. The 30 revised full papers presented were carefully reviewed and selected from 93 submissions and are presented together with 2 invited papers. The papers present original research in the theory and applications of algorithms and computational complexity."]