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[null,"1.","Record Nr.",null,"UNINA9910765530003321"]
[null,null,"Autore",null,"Abélès Solal"]
[null,null,"Titolo",null,"Protéger, libérer, assujettir : L'expansion territoriale de la commune de Florence au XIVe siècle"]
[null,null,"Pubbl/distr/stampa",null,"Rome, : Publications de l'École française de Rome, 2023"]
[null,null,"ISBN",null,"2-7283-1578-7"]
[null,null,"Descrizione fisica",null,"1 online resource (360 p.)"]
[null,null,"Collana",null,"Collection de l'École française de Rome ; ; 603"]
[null,null,"Soggetti",null,"Early history: c 500 to c 1450/1500"]
[{"$nulls":4},"European history"]
[{"$nulls":4},"History"]
[{"$nulls":4},"Sources."]
[{"$nulls":4},"Florence (Italy) History To 1421 Historiography"]
[{"$nulls":4},"Florence (Italy) Politics and government To 1421"]
[{"$nulls":4},"Florence (Italy) Territorial expansion History To 1500"]
[{"$nulls":4},"Tuscany (Italy) Politics and government To 1434"]
[null,null,"Lingua di pubblicazione",null,"Francese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Au milieu du XIVe siècle, la commune de Florence, qui ne contrôlait jusqu'alors qu'un petit territoire au-delà des murs de la cité, le contado, réussit à assujettir les six principaux centres urbains voisins : Colle Valdelsa, San Gimignano, Prato, Pistoia, Volterra et San Miniato. Pour mener à bien cet assujettissement, le pouvoir florentin ne pouvait cependant se contenter d'une pure et simple conquête militaire : l'issue en aurait été non seulement incertaine mais surtout très difficile à consolider dans le temps. Car même s'ils n'avaient pas atteint l'importance démographique des grandes cités de la région, les centres convoités étaient parvenus à maintenir leur autonomie depuis plus d'un siècle. Ils avaient par conséquent développé une identité politique et culturelle propre, en vertu de laquelle ils auraient pu, une fois conquis, refuser la soumission et constituer partant des foyers permanents de révolte. D'où la nécessité pour les Florentins d'élaborer des instruments en mesure de légitimer leur domination et d'en assurer ainsi la pérennité. Quels furent les mécanismes explicites et implicites de cette entreprise de légitimation ? À partir d'une étude approfondie des actes "]
[{"$nulls":4},"juridiques qui formalisèrent la soumission et du discours produit sur celle-ci par les chroniques contemporaines, cet ouvrage en analyse les ressorts politiques et culturels. Il permet ainsi de comprendre comment et pourquoi cet assujettissement fut paradoxalement pensé comme la condition nécessaire au maintien de la libertas."]
[null,"2.","Record Nr.",null,"UNINA9910161647503321"]
[null,null,"Autore",null,"Alvaro R. Lara"]
[null,null,"Titolo",null,"Quantitative Systems Biology for Engineering Organisms and Pathways"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2016"]
[null,null,"Descrizione fisica",null,"1 online resource (126 p.)"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[null,null,"Soggetti",null,"Biotechnology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Studying organisms as a whole for potential metabolic(ally) engineering of organisms for production of (bio)chemicals is essential for industrial biotechnology. To this end, integrative analysis of different -omics measurements (transciptomics, proteomics, metabolomics, fluxomics) provides invaluable information. Combination of experimental top-down and bottom-up approaches with powerful analytical tools/techniques and mathematical modeling, namely (quantitative) systems biology, currently making the state of art of this discipline, is the only practice that would improve our understanding for the purpose. The use of high-throughput technologies induced the required development of many bioinformatics tools and mathematical methods for the integration of obtained data. Such research is significant since compiling information from different levels of a living system and connecting them is not an easy task. In particular, construction of dynamic models for product improvement has been one of the goals of many research groups. In this Research Topic, we summarize and bring a general review of the most recent and relevant contributions in quantitative systems biology applied in metabolic modeling perspective. We want to make special emphasis on the techniques that can be widely implemented in regular scientific laboratories and in those works that include theoretical presentations. With this Research Topic we discuss the importance of applying systems biology approaches for finding metabolic engineering targets for the efficient production of the desired biochemical integrating information from genomes and networks to industrial production. Examples and perspectives in the design of new industrially relevant "]
[{"$nulls":4},"chemicals, e.g. increased titer/productivity/yield of (bio)chemicals, are welcome. Addition to the founded examples, potential new techniques that would frontier the research will be part of this topic. The significance of multi 'omics' approaches to understand/uncover the pathogenesis/mechanisms of metabolic diseases is also one of the main topics."]