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[null,"1.","Record Nr.",null,"UNINA9910154743303321"]
[null,null,"Autore",null,"Mostow G. Daniel"]
[null,null,"Titolo",null,"Strong Rigidity of Locally Symmetric Spaces. (AM-78), Volume 78 / / G. Daniel Mostow"]
[null,null,"Pubbl/distr/stampa",null,"Princeton, NJ : , : Princeton University Press, , [2016]"]
[{"$nulls":4},"©1974"]
[null,null,"ISBN",null,"1-4008-8183-8"]
[null,null,"Descrizione fisica",null,"1 online resource (205 pages)"]
[null,null,"Collana",null,"Annals of Mathematics Studies ; ; 247"]
[null,null,"Disciplina",null,"516/.36"]
[null,null,"Soggetti",null,"Riemannian manifolds"]
[{"$nulls":4},"Symmetric spaces"]
[{"$nulls":4},"Lie groups"]
[{"$nulls":4},"Rigidity (Geometry)"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,"Nota di contenuto",null,"Frontmatter -- Contents -- §1. Introduction -- §2. Algebraic Preliminaries -- §3. The Geometry of χ : Preliminaries -- §4. A Metric Definition of the Maximal Boundary -- §5. Polar Parts -- §6. A Basic Inequality -- §7. Geometry of Neighboring Flats -- §8. Density Properties of Discrete Subgroups -- §8. Density Properties of Discrete Subgroups -- § 10. Pseudo Isometries of Simply Connected Spaces with Negative Curvature -- §11. Polar Regular Elements in Co-Compact Γ -- § 12. Pseudo-Isometric Invariance of Semi-Simple and Unipotent Elements -- §13. The Basic Approximation -- §14. The Map ∅̅ -- §15. The Boundary Map ∅0 -- §16. Tits Geometries -- §17. Rigidity for R-rank > 1 -- §18. The Restriction to Simple Groups -- §19. Spaces of R-rank 1 -- §20. The Boundary Semi-Metric -- §21. Quasi-Conformal Mappings Over K and Absolute Continuity on Almost All R-Circles -- §22. The Effect of Ergodicity -- §23. R-Rank 1 Rigidity Proof Concluded -- §24. Concluding Remarks -- Bibliography -- Backmatter"]
[null,null,null,"Sommario/riassunto","Locally symmetric spaces are generalizations of spaces of constant curvature. In this book the author presents the proof of a remarkable phenomenon, which he calls \"strong rigidity\": this is a stronger form of the deformation rigidity that has been investigated by Selberg, Calabi-Vesentini, Weil, Borel, and Raghunathan.The proof combines the theory of semi-simple Lie groups, discrete subgroups, the geometry of E. Cartan's symmetric Riemannian spaces, elements of ergodic theory, and "]
[{"$nulls":4},"the fundamental theorem of projective geometry as applied to Tit's geometries. In his proof the author introduces two new notions having independent interest: one is \"pseudo-isometries\"; the other is a notion of a quasi-conformal mapping over the division algebra K (K equals real, complex, quaternion, or Cayley numbers). The author attempts to make the account accessible to readers with diverse backgrounds, and the book contains capsule descriptions of the various theories that enter the proof."]
[null,"2.","Record Nr.",null,"UNINA9910136793803321"]
[null,null,"Autore",null,"Christophe M. Filippi"]
[null,null,"Titolo",null,"Toll-Like Receptor Activation in Immunity vs. Tolerance"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2015"]
[null,null,"Descrizione fisica",null,"1 online resource (75 p.)"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[null,null,"Soggetti",null,"Medicine"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","The innate immune system has evolved means to recognize and react suitably to foreign entities such as infectious agents. In many cases infectious microorganisms threaten the integrity and function of the target organs or tissues; therefore, consequent to their recognition the immune system becomes activated to ensure their elimination. Toll-like receptors (TLR) constitute a family of receptors specialized in the recognition of molecular patterns typically associated with infectious agents. Different TLRs exist, each selective for molecular entities and motifs belonging to a specific pathogen group. Consequently, it is thought that the molecular nature of invading microorganisms activates specific TLRs to drive adequate anti-infectious immunity. For instance, nucleic acid-specific, intracellular receptors (TLR3/7/8/9) are used to sense viruses and drive antiviral immunity, while other receptors (such as TLR2 and TLR4) recognize and promote immunity against bacteria, yeast, and fungi. Yet, it is becoming evident that activation of TLR pathways trigger mechanisms that not only stimulate but also regulate the immune system. For instance, TLR stimulation by viruses will drive antiviral interferon but also immunoregulatory cytokine production and regulatory T cell activation. Stimulation of TLRs by bacteria or using molecular agonists can also trigger both immune stimulatory and regulatory responses. TLR stimulation by infectious agents likely serves to activate but also control anti-infectious immunity, for instance prevent potential immunopathological tissue damage which can be caused by acute immune defense mechanisms. Previous work by us and others has shown that the immunoregulatory arm of TLR stimulation can additionally help control autoreactive processes in autoimmune "]
[{"$nulls":4},"disease. Hence, it is becoming established that gut commensals, which also play a crucial part in the control of autoimmune disease, establish immune regulatory mechanisms through activation of particular TLRs. In sum, it appears that TLRs are key immune players that not only stimulate but also regulate immune processes in health and disease. In this Research Topic, we wish to review the dual role of TLRs as activators and regulators of immune responses. We aim to motivate data-driven opinions as to the importance of context of TLR agonism for determining immune activation vs. regulation. The presentation of ongoing original works, as well as data and opinions around other innate immune receptors pertaining to this topic, are also encouraged."]