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[null,"1.","Record Nr.",null,"UNINA9910146416703321"]
[null,null,"Titolo",null,"Skin sensitization in chemical risk assessment"]
[null,null,"Pubbl/distr/stampa",null,"Geneva, Switzerland, : World Health Organization, c2008"]
[null,null,"ISBN",null,"9786611937799"]
[{"$nulls":4},"9781281937797"]
[{"$nulls":4},"1281937797"]
[{"$nulls":4},"9789240683440"]
[{"$nulls":4},"9240683445"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (90 p.)"]
[null,null,"Collana",null,"Harmonization Project document ; ; no. 5"]
[null,null,"Disciplina",null,"616.994071"]
[null,null,"Soggetti",null,"Chemicals - Physiological effect"]
[{"$nulls":4},"Chemicals - Risk assessment"]
[{"$nulls":4},"Skin tests"]
[{"$nulls":4},"Toxicology"]
[{"$nulls":4},"Health risk assessment"]
[{"$nulls":4},"Hazardous susbtances - Risk assessment"]
[{"$nulls":4},"Health status indicators"]
[{"$nulls":4},"Dermatitis, Contact - physiopathology"]
[{"$nulls":4},"Hazardous Substances - toxicity"]
[{"$nulls":4},"Skin Tests - methods"]
[{"$nulls":4},"Risk Assessment - methods"]
[{"$nulls":4},"Skin Tests"]
[{"$nulls":4},"Health Status Indicators"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","\"IPCS International Programme on Chemical Safety\"."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,"Nota di contenuto",null,"Skin Sensitization in Chemical Risk Assessment: Report of a WHO/IPCS International Workshop Focusing on Dose-Response Assessment / H. Van Loveren, A. Cockshott, T. Gebel, U. Gundert-Remy, W.H. De Jong, J. Matheson, H. McGarry, L. Musset, M.K. Selgrade and C. Vickers -- Appendix A. Abstracts -- The use of human data when conducting dermal sensitization quantitative risk assessments for fragrance ingredients / A.M. Api -- Application of the local lymph node assay (LLNA) for respiratory sensitizers / J.H.E. Arts, W.H. De Jong, H. Van Loveren and C.F. Kuper -- Information derived from sensitization test "]
[{"$nulls":4},"methods: test sensitivity, false positives, and false negatives / D. Basketter -- Skin sensitization -- a regulatory overview / A. Cockshott -- Quantification, potency, and risk assessment: induction versus elicitation / G.P. Gerberick -- Uncertainty factors and risk assessment for skin sensitizers / P. Griem -- Hazard identification (human data) / J.D. Johansen -- Clinical experience informing risk assessment / C. Liden -- Perspective of the United States Environmental Protection Agency's Office of Pesticide Programs on assessment of dermal sensitization risk using hexavalent chromium as a case-study / T.F. McMahon and J. Chen -- New approaches for skin sensitization hazard identification: (Q)SARs/expert systems / G. Patlewicz -- New approaches for hazard identification: the development of in vitro methods for predicting contact sensitization potential / C.A. Ryan -- Sensitization potency of chemicals / M. Takeyoshi -- New approaches to hazard identification: non-radioactive alternatives / H.-W. Vohr."]
[null,null,null,"Sommario/riassunto","This Harmonization Project Document presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of methods for dose-response assessment, to evaluate the relative ability of a chemical to induce sensitization in the skin, and hence inform risk assessment for humans. In addition this publication includes a series of short articles on this topic by leading experts in the field. The conclusions of the workshop cover such aspects as the nature and utility for risk assessment of the data produced by non-animal test methods (suc"]