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[null,"1.","Record Nr.",null,"UNINA9910144736103321"]
[null,null,"Titolo",null,"Immunological tolerance [[electronic resource] /] / [editors, Gregory R. Bock (organizer) and Jamie A. Goode]"]
[null,null,"Pubbl/distr/stampa",null,"Chichester ; ; New York, : J. Wiley & Sons, 1998"]
[null,null,"ISBN",null,"1-282-12249-5"]
[{"$nulls":4},"9786612122491"]
[{"$nulls":4},"0-470-51552-X"]
[{"$nulls":4},"0-470-51553-8"]
[null,null,"Descrizione fisica",null,"1 online resource (250 p.)"]
[null,null,"Collana",null,"Novartis Foundation symposium ; ; 215"]
[null,null,"Disciplina",null,"571.96"]
[{"$nulls":4},"616.079"]
[null,null,"Soggetti",null,"Immunological tolerance"]
[{"$nulls":4},"Autoimmunity"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","\"Symposium on Immunological Tolerance, held at the Novartis Foundation, London, 8-10 July 1997\"--P. v."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and indexes."]
[null,null,"Nota di contenuto",null,"IMMUNOLOGICAL TOLERANCE; Contents; Participants; Introduction; Mechanisms of peripheral T cell tolerance; B cell antigen receptor signalling in the balance of tolerance and immunity; General discussion I; The study of self-tolerance using murine haemoglobin as a model self antigen; Tolerance and determinant hierarchy; Molecular genetic studies in lymphocyte apoptosis and human autoimmunity; General discussion II; A role for CTLA-4-mediated inhibitorv J signals in peripheral T cell tolerance?"]
[{"$nulls":4},"Antigen-specific CD4+ T cells that survive after the induction of peripheral tolerance possess an intrinsic lymphokine production defectAntigen-specific tolerance induction and the immunotherapy of experimental autoimmune disease; Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes; Tolerance induction with CD4 monoclonal antibodies; A two-step model for the induction of organ-specific autoimmunity; Cross-presentation of self antigens to CDW T cells: the balance between tolerance and autoimmunity; General discussion III"]
[{"$nulls":4},"Tolerance induction in mature T lymphocytesT lymphocyte-mediated control of autoimmunity; Final general discussion; Index of "]
[{"$nulls":4},"contributors; Subject index"]
[null,null,null,"Sommario/riassunto","This book brings together material on all aspects of immunological tolerance. Basic mechanisms of tolerance are examined in detail, including mechanisms of peripheral T cell tolerance, molecular and genetic mechanisms for maintaining self tolerance, partial T cell activation, and the role of apoptosis in tolerance. Careful consideration is also given to the clinical applications of our understanding of immunological tolerance, with specific chapters dealing with T cell activation during tumour therapy, antiantigen specific immune suppression, tolerance in infectious diseases, tolerance during"]