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[null,"1.","Record Nr.",null,"UNINA9910144683203321"]
[null,null,"Autore",null,"Amaratunga Dhammika <1956->"]
[null,null,"Titolo",null,"Exploration and analysis of DNA microarray and protein array data [[electronic resource] /] / Dhammika Amaratunga, Javier Cabrera"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, NJ, : John Wiley, c2004"]
[null,null,"ISBN",null,"1-282-30744-4"]
[{"$nulls":4},"9786612307447"]
[{"$nulls":4},"0-470-31712-4"]
[{"$nulls":4},"0-470-31796-5"]
[null,null,"Descrizione fisica",null,"1 online resource (270 p.)"]
[null,null,"Collana",null,"Wiley series in probability and statistics"]
[null,null,"Disciplina",null,"572.8"]
[{"$nulls":4},"572.8636"]
[null,null,"Soggetti",null,"DNA microarrays - Statistical methods"]
[{"$nulls":4},"Protein microarrays - Statistical methods"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. 222-236) and indexes."]
[null,null,"Nota di contenuto",null,"Exploration and Analysis of DNA Microarray and Protein A rray Data; Contents; Preface; 1. A Brief Introduction; 1.1. A Note on Exploratory Data Analysis; 1.2. Computing Considerations and Software; 1.3. A Brief Outline of the Book; 2. Genomics Basics; 2.1. Genes; 2.2. DNA; 2.3. Gene Expression; 2.4. Hybridization Assays and Other Laboratory Techniques; 2.5. The Human Genome; 2.6. Genome Variations and Their Consequences; 2.7. Genomics; 2.8. The Role of Genomics in Pharmaceutical Research; 2.9. Proteins; 2.10. Bioinformatics; Supplementary Reading; Exercises; 3. Microarrays"]
[{"$nulls":4},"3.1. Types of Microarray Experiments3.1.1. Experiment Type 1: Tissue-Specific Gene Expression; 3.1.2. Experiment Type 2: Developmental Genetics; 3.1.3. Experiment Type 3: Genetic Diseases; 3.1.4. Experiment Type 4: Complex Diseases; 3.1.5. Experiment Type 5: Pharmacological Agents; 3.1.6. Experiment Type 6: Plant Breeding; 3.1.7. Experiment Type 7: Environmental Monitoring; 3.2. A Very Simple Hypothetical Microarray Experiment; 3.3. A Typical Microarray Experiment; 3.3.1. Microarray Preparation; 3.3.2. Sample Preparation; 3.3.3. The Hybridization Step; 3.3.4. Scanning the Microarray"]
[{"$nulls":4},"3.3.5. Interpreting the Scanned Image3.4. Multichannel cDNA Microarrays; 3.5. Oligonucleotide Arrays; 3.6. Bead-Based Arrays; 3.7. "]
[{"$nulls":4},"Confirmation of Microarray Results; Supplementary Reading and Electronic References; Exercises; 4. Processing the Scanned Image; 4.1. Converting the Scanned Image to the Spotted Image; 4.1.1. Gridding; 4.1.2. Segmentation; 4.1.3. Quantification; 4.2. Quality Assessment; 4.2.1. Visualizing the Spotted Image; 4.2.2. Numerical Evaluation of Array Quality; 4.2.3. Spatial Problems; 4.2.4. Spatial Randomness; 4.2.5. Quality Control of Arrays"]
[{"$nulls":4},"4.2.6. Assessment of Spot Quality4.3. Adjusting for Background; 4.3.1. Estimating the Background; 4.3.2. Adjusting for the Estimated Background; 4.4. Expression Level Calculation for Two-Channel cDNA Microarrays; 4.5. Expression Level Calculation for Oligonucleotide Arrays; 4.5.1. The Average Difference; 4.5.2. A Weighted Average Difference; 4.5.3. Perfect Matches Only; 4.5.4. Background Adjustment Approach; 4.5.5. Model-Based Approach; 4.5.6. Absent-Present Calls; Supplementary Reading; Exercises; 5. Preprocessing Microarray Data; 5.1. Logarithmic Transformation"]
[{"$nulls":4},"5.2. Variance Stabilizing Transformations5.3. Sources of Bias; 5.4. Normalization; 5.5. Intensity-Dependent Normalization; 5.5.1. Smooth Function Normalization; 5.5.2. Quantile Normalization; 5.5.3. Normalization of Oligonucleotide Arrays; 5.5.4. Normalization of Two-Channel Arrays; 5.5.5. Spatial Normalization; 5.5.6. Stagewise Normalization; 5.6. Judging the Success of a Normalization; 5.7. Outlier Identification; 5.7.1 Nonresistant Rules for Outlier Identification; 5.7.2. Resistant Rules for Outlier Identification; 5.8. Assessing Replicate Array Quality; Exercises; 6. Summarization"]
[{"$nulls":4},"6.1. Replication"]
[null,null,null,"Sommario/riassunto","A cutting-edge guide to the analysis of DNA microarray data Genomics is one of the major scientific revolutions of this century, and the use of microarrays to rapidly analyze numerous DNA samples has enabled scientists to make sense of mountains of genomic data through statistical analysis. Today, microarrays are being used in biomedical research to study such vital areas as a drug's therapeutic value-or toxicity-and cancer-spreading patterns of gene activity. Exploration and Analysis of DNA Microarray and Protein Array Data answers the need for a comprehensive, cutting-edge overview of th"]
[null,"2.","Record Nr.",null,"UNINA9910788075403321"]
[null,null,"Autore",null,"Schoolman Martha"]
[null,null,"Titolo",null,"Abolitionist Geographies / / Martha Schoolman"]
[null,null,"Pubbl/distr/stampa",null,"Minneapolis, Minnesota : , : University of Minnesota Press, , 2014"]
[{"$nulls":4},"©2014"]
[null,null,"ISBN",null,"1-4529-4212-9"]
[null,null,"Descrizione fisica",null,"1 online resource (238 p.)"]
[null,null,"Disciplina",null,"326/.8097309034"]
[null,null,"Soggetti",null,"Antislavery movements - United States - History - 19th century"]
[{"$nulls":4},"Abolitionists - United States - History - 19th century"]
[{"$nulls":4},"Geography in literature"]
[{"$nulls":4},"Antislavery movements in literature"]
[{"$nulls":4},"African Americans in literature"]
[{"$nulls":4},"American literature - 19th century - History and criticism"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Cover; Contents; Introduction: What Is Abolitionist Geography?; 1. Emerson's Hemisphere; 2. August First and the Practice of Disunion; 3. William Wells Brown's Critical Cosmopolitanism; 4. Uncle Tom's Cabin's Anti-expansionism; 5. The Maroon's Moment, 1856- 1861; Acknowledgments; Notes; Index; A; B; C; D; E; F; G; H; J; K; L; M; N; O; P; R; S; T; V; W"]
[null,null,null,"Sommario/riassunto","Traditional narratives of the period leading up to the Civil War are invariably framed in geographical terms. The sectional descriptors of the North, South, and West, like the wartime categories of Union, Confederacy, and border states, mean little without reference to a map of the United States. In Abolitionist Geographies, Martha Schoolman contends that antislavery writers consistently refused those standard terms. Through the idiom Schoolman names \"abolitionist geography,\" these writers instead expressed their dissenting views about the westward extension of slavery, the intensification of"]