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[null,"1.","Record Nr.",null,"UNINA9910144557103321"]
[null,null,"Titolo",null,"Antigen presenting cells : from mechanisms to drug development / / edited by Harald Kropshofer and Anne B. Vogt"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim, : Wiley-VCH, c2005"]
[null,null,"ISBN",null,"9786610854073"]
[{"$nulls":4},"9781280854071"]
[{"$nulls":4},"1280854073"]
[{"$nulls":4},"9783527607020"]
[{"$nulls":4},"3527607021"]
[{"$nulls":4},"9783527606986"]
[{"$nulls":4},"352760698X"]
[null,null,"Descrizione fisica",null,"1 online resource (653 p.)"]
[null,null,"Classificazione",null,"42.15"]
[null,null,"Disciplina",null,"571.9/677"]
[null,null,"Soggetti",null,"Antigen presenting cells"]
[{"$nulls":4},"Antigenen"]
[{"$nulls":4},"Celbiologie"]
[{"$nulls":4},"Farmacologie"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Antigen Presenting Cells; Contents; Preface; Acknowledgments; List of Contributors; List of Abbreviations; Color Plates; Part I Antigen Presentation in the Immune System; 1 Some Old and Some New Findings on Antigen Processing and Presentation; 1.1 Introduction; 1.2 HEL Processing; 1.3 Selection of Peptide Segments of HEL; 1.4 HEL: Conformational Isomers; 1.4.1 Biology of Type B T Cells; 1.5 Negative Selection and Peripheral Activation to HEL Peptides; 1.6 Response to HEL Immunization in the Draining Lymph Node; Part II Molecular Mechanisms of Antigen Processing"]
[{"$nulls":4},"2 Antigen Entry Routes - Where Foreign Invaders Meet Antigen Presenting Cells2.1 Introduction; 2.2 Antigen Entry via the Gastrointestinal Tract; 2.2.1 Peyer's Patches; 2.2.2 Mesenteric Lymph Node; 2.2.3 Dendritic Cells of the Lamina Propria; 2.2.4 Pathogens Target Intestinal Antigen Presenting Cells; 2.3 Antigen Entry via the Skin; 2.4 Systemic Dissemination of Antigens/Infectious Microorganisms; 2.5 Antigen Presenting Cells in the Liver; 2.5.1 "]
[{"$nulls":4},"Dendritic Cells; 2.5.2 Kupffer Cells; 2.5.3 Liver Sinusoidal Endothelial Cells; 2.6 Conclusion"]
[{"$nulls":4},"3 Antigen Processing in the Context of MHC Class I Molecules3.1 Tracing the Needle in the Haystack: The Efficiency of Antigen Processing and Presentation by MHC Class I Molecules; 3.2 The \"Classical\" Route: Loading of MHC Class I Molecules With Peptides Generated in the Cytoplasm; 3.2.1 Cytosolic Peptide Processing by Proteasomes and other Proteases; 3.2.1.1 Structure and Function of the Proteasomal Core and Interferon-induced Subunits; 3.2.1.2 Targeting Proteins for ATP-dependent Degradation by 26S Proteasomes; 3.2.1.3 Cleavage Properties of (Immuno)Proteasomes"]
[{"$nulls":4},"3.2.1.4 Peptide Processing by Nonproteasomal Cytosolic Peptidases3.3 Crossing the Border - Peptide Translocation into the ER by TAP; 3.3.1 Structure and Function of TAP; 3.3.2 Substrate Specificity of TAP; 3.3.3 TAP-independent Peptide Entry into the ER; 3.4 Fitting in the Best: TAP-associated Peptide Loading Complex Optimizes MHC-I Peptide Binding; 3.4.1 Structure of MHC-I Molecules; 3.4.2 Early Steps in the Maturation of MHC-I Molecules; 3.4.3 Structure and Molecular Interactions of Tapasin; 3.4.4 Optimization of Peptide Loading in the TAP-associated Loading Complex"]
[{"$nulls":4},"3.5 On the Way Out: MHC-I Antigen Processing along the Secretory Route3.6 Closing the Circle - Cross-presentation of Endocytosed Antigens by MHC-I Molecules; 3.6.1 Phagosome-to-cytosol Pathway of MHC-I Peptide Loading; 3.6.2 Endolysosomal Pathway of MHC-I Peptide Loading; 4 Antigen Processing for MHC Class II; 4.1 Introduction; 4.2 Types of Antigen Presenting Cells; 4.2.1 Macrophages, B Lymphocytes and DCs; 4.2.2 Tissue-resident APCs; 4.2.3 Maturation State of APCs; 4.2.3.1 Immature APCs; 4.2.3.2 Mature APCs; 4.3 Antigen Uptake by APCs; 4.3.1 Macropinocytosis; 4.3.2 Phagocytosis"]
[{"$nulls":4},"4.3.3 Receptors for Endocytosis"]
[null,null,null,"Sommario/riassunto","This novel, multidisciplinary handbook highlights recent evidence that antigen presenting cells (APCs) are not only key players in the initiation or prevention of an antigen-specific T lymphocyte-mediated adaptive immune response, but also critical regulators and integrators in the interplay between our innate and adaptive immune system.Structured in a clear way to allow access to a very broad readership, the book is written from the viewpoint of a biochemist, immunologist, and scientist with experience in drug development. It covers all cell types involved in antigen presentation, providi"]