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[null,"1.","Record Nr.",null,"UNINA9910144273603321"]
[null,null,"Titolo",null,"Fragment-based approaches in drug discovery [[electronic resource] /] / edited by Wolfgang Jahnke and Daniel A. Erlanson"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim, : Wiley-VCH"]
[{"$nulls":4},"[Chichester, : John Wiley, distributor], c2006"]
[null,null,"ISBN",null,"1-280-72281-9"]
[{"$nulls":4},"9786610722815"]
[{"$nulls":4},"3-527-60876-1"]
[{"$nulls":4},"3-527-60860-5"]
[null,null,"Descrizione fisica",null,"1 online resource (393 p.)"]
[null,null,"Collana",null,"Methods and principles in medicinal chemistry ; ; 34"]
[null,null,"Disciplina",null,"615"]
[{"$nulls":4},"615.1901"]
[null,null,"Soggetti",null,"Drug development"]
[{"$nulls":4},"Ligands (Biochemistry)"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Fragment-based Approaches in Drug Discovery; Contents; Preface; A Personal Foreword; List of Contributors; Part I: Concept and Theory; 1 The Concept of Fragment-based Drug Discovery; 1.1 Introduction; 1.2 Starting Small: Key Features of Fragment-based Ligand Design; 1.2.1 FBS Samples Higher Chemical Diversity; 1.2.2 FBS Leads to Higher Hit Rates; 1.2.3 FBS Leads to Higher Ligand Efficiency; 1.3 Historical Development; 1.4 Scope and Overview of this Book; References; 2 Multivalency in Ligand Design; 2.1 Introduction and Overview; 2.2 Definitions of Terms"]
[{"$nulls":4},"2.3 Selection of Key Experimental Studies2.3.1 Trivalency in a Structurally Simple System; 2.3.2 Cooperativity (and the Role of Enthalpy) in the \"Chelate Effect\"; 2.3.3 Oligovalency in the Design of Inhibitors to Toxins; 2.3.4 Bivalency at Well Defined Surfaces (Self-assembled Monolayers, SAMs); 2.3.5 Polyvalency at Surfaces of Viruses, Bacteria, and SAMs; 2.4 Theoretical Considerations in Multivalency; 2.4.1 Survey of Thermodynamics; 2.4.2 Additivity and Multivalency; 2.4.3 Avidity and Effective Concentration (C(eff)); 2.4.4 Cooperativity is Distinct from Multivalency"]
[{"$nulls":4},"2.4.5 Conformational Entropy of the Linker between Ligands2.4.6 "]
[{"$nulls":4},"Enthalpy/Entropy Compensation Reduces the Benefit of Multivalency; 2.5 Representative Experimental Studies; 2.5.1 Experimental Techniques Used to Examine Multivalent Systems; 2.5.1.1 Isothermal Titration Calorimetry; 2.5.1.2 Surface Plasmon Resonance Spectroscopy; 2.5.1.3 Surface Assays Using Purified Components (Cell-free Assays); 2.5.1.4 Cell-based Surface Assays; 2.5.2 Examination of Experimental Studies in the Context of Theory; 2.5.2.1 Trivalency in Structurally Simple Systems"]
[{"$nulls":4},"2.5.2.2 Cooperativity (and the Role of Enthalpy) in the \"Chelate Effect\"2.5.2.3 Oligovalency in the Design of Inhibitors of Toxins; 2.5.2.4 Bivalency in Solution and at Well Defined Surfaces (SAMs); 2.5.2.5 Polyvalency at Surfaces (Viruses, Bacteria, and SAMs); 2.6 Design Rules for Multivalent Ligands; 2.6.1 When Will Multivalency Be a Successful Strategy to Design Tight-binding Ligands?; 2.6.2 Choice of Scaffold for Multivalent Ligands; 2.6.2.1 Scaffolds for Oligovalent Ligands; 2.6.2.2 Scaffolds for Polyvalent Ligands; 2.6.3 Choice of Linker for Multivalent Ligands"]
[{"$nulls":4},"2.6.3.1 Rigid Linkers Represent a Simple Approach to Optimize Affinity2.6.3.2 Flexible Linkers Represent an Alternative Approach to Rigid Linkers to Optimize Affinity; 2.6.4 Strategy for the Synthesis of Multivalent Ligands; 2.6.4.1 Polyvalent Ligands: Polymerization of Ligand Monomers; 2.6.4.2 Polyvalent Ligands: Functionalization with Ligands after Polymerization; 2.7 Extensions of Multivalency to Lead Discovery; 2.7.1 Hetero-oligovalency Is a Broadly Applicable Concept in Ligand Design; 2.7.2 Dendrimers Present Opportunities for Multivalent Presentation of Ligands"]
[{"$nulls":4},"2.7.3 Bivalency in the Immune System"]
[null,null,null,"Sommario/riassunto","This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies."]
[null,"2.","Record Nr.",null,"UNINA9910786516203321"]
[null,null,"Autore",null,"Ó Searcaigh Cathal"]
[null,null,"Titolo",null,"Ag Tnúth leis an tSolas [[electronic resource]]"]
[null,null,"Pubbl/distr/stampa",null,"Gaillimh, : Cló lar-Chonnacht, 2000"]
[null,null,"ISBN",null,"1-909367-79-6"]
[{"$nulls":4},"1-909367-78-8"]
[null,null,"Descrizione fisica",null,"1 online resource (380 p.)"]
[null,null,"Disciplina",null,"891.6/2143"]
[null,null,"Soggetti",null,"Ireland -- Poetry"]
[{"$nulls":4},"Ireland"]
[{"$nulls":4},"Poetry"]
[{"$nulls":4},"Ireland Poetry"]
[null,null,"Lingua di pubblicazione",null,"Irlandese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,"Nota di contenuto",null,"Page Cóipcheart; Clár; Réamhrá; Miontragóid Chathrach 1975; Cinniúint; Teach; Páirc Mhéabha; Rannpháirtíocht; Sráideacha; High Street, Kensington, 6 P.M.; Cíoradh; Deoraíocht; Smaointiú; Cathair; If you're going to San Falcarragh be sure to wear your rosary beads in your hair; Miontragóid Chathrach; Gréagach; Blues na Bealtaine; Rothaí Móra an tSaoil; Glas; Mín an Leá: Tráthnóna; Searc; Tuirlingt 1978; Díle; Cor na Sióg; Mar a b'Ainmhian Liom; Seoinín Mhín an Lábáin; Amhrán na Maidine; Notturno; Amhrán na hOíche; Scríbhinní; Cumha na gCarad; Spréach; Caill; Soinéad; Amhrán an Mharcaigh"]
[{"$nulls":4},"CeachtCeacht an tSiúinéara; Súile Shuibhne 1983; Londain; Gladstone Park; Portráid den Ghabha mar Ealaíontóir Óg; Sú Talún; Aon Séasúr den Bhliain; Cor Úr; Níl Aon Ní; Maidin i Mín an Leá; Súile Shuibhne; Fiacha an tSolais; Agallamh na Seanórach; Tearmann; An Tobar; Briathra agus Bráithre; An tAngelus; I gCeann mo Thrí Bliana a Bhí Mé; Scrúdú Coinsiasa roimh Dul chun Suain; Na Píopaí Créafóige; Idir Mám an tSeantí agus Loch na mBreac Beadaí; Ádh; Trasnú; Marbhna; Séasúir; Scuaine; An Bás; Cinniúint; Dia: Nótaí Anailíse; Transubstaintiú; Taobh Thiar; Aoibh; Searmanas; Jericho; Dídean; Muirbhé"]
[{"$nulls":4},"Nuair ba Ghnách liom Luí le mo ThuismitheoiríInsomnia; Suibhne 1987; Ma Bohème; Uamhan; Maigdiléana; An tAonarán; Attic; Piccadilly: Teacht na hOíche; Cuisle an Chaoráin; Triall; Umhlaigh; Anseo ag Stáisiún Chaiseal na gCorr; Abhainn an Átha; Uchtach; Bean an tSléibhe; Caoradóir; Taispeánadh; Oícheanta Geimhridh; Cré; Sneachta; Dia Aon "]
[{"$nulls":4},"Lae; Ciúnas; Fothrach Tí i Mín na Craoibhe; Coirnéal na Sráide; Bó Bhradach; An Díbeartach; Pilleadh an Deoraí; Rothaí Móra na Bliana; Rothaí Móra na Bliana; Caoineadh; Cancer; Johnny Appleseed; Do Jack Kerouac; Súile Soir; Súile Soir; Máirtín Ó Direáin"]
[{"$nulls":4},"SoinéadCrainn; Soilse; Fios; Dúil; Ceann Dubh Dílis; Tá Mé ag Síorshiúl Sléibhe; Oíche Ghealaí i nGaililí 1993; Homecoming/An Bealach 'na Bhaile 1993; Tá mo Chéadsearc i Londain; Laoi Cumainn; Mise Charlie an Scibhí; D'Ainm; Is Glas na Cnoic; Lá de na Laethanta; Dathanna; Na Buachaillí Bána 1996; A Chavafy, a Chroí; Geasa; I gcead do Chavafy: trí dhán; Gorm; Oíche; Buachaill Bán; Súil Solais; Fios; Anghrá; Samhradh; Samhain 1976/'84/'94; Buachaill; Uaigneas; Maolú; Slán; A Mhianta m'Óige; Gort na gCnámh; Cré na Cuimhne; An Lilí Bhándearg; An Duibheagán; An Garraíodóir; Cathaoir Uillinne"]
[{"$nulls":4},"DréimireCleopatra; Ceannóga; Out in the Open 1997; Cainteoir Dúchais; Ag Faire do Shuain; Amhráin Bheaga; Spliontair; Do Narayan Shrestha; Kathmandu; Do Isaac Rosenberg; Ag Tnúth Leis an tSolas 2000; Fís na hOíche; Aistear; Do Felim Egan, ealaíontóir; Mian; Trasnú; Amhrán; Amhrán ón Albáinis; Dá bhFaighinn Bás; Craos; A Bhuachaill na Gréine; Aibiú; Sa Chisteanach; An Damhsa; An Crann ag Caint; An Fear Glas; Claochló; I nGairdín Ghleann Bheithe; Tráthnóna Samhna; An Bealach nach bhFilleann; An tEargal; Siúl Samhna; Altú"]
[null,null,null,"Sommario/riassunto","Ag Tnúth leis an tSolas is a celebration of Cathal Ó Searcaigh's work 1975-2000, including hitherto unpublished poems and a play.The original printed version of this book includes a CD which is not included in the ebook version."]