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[null,"1.","Record Nr.",null,"UNINA9910144110203321"]
[null,null,"Titolo",null,"Advanced computer-assisted techniques in drug discovery [[electronic resource] /] / edited by Han van de Waterbeemd"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim ; ; New York, : VCH, c1995"]
[null,null,"ISBN",null,"1-281-84288-5"]
[{"$nulls":4},"9786611842888"]
[{"$nulls":4},"3-527-61567-9"]
[{"$nulls":4},"3-527-61566-0"]
[null,null,"Descrizione fisica",null,"1 online resource (367 p.)"]
[null,null,"Collana",null,"Methods and principles in medicinal chemistry ; ; v. 3"]
[null,null,"Disciplina",null,"615.10285"]
[{"$nulls":4},"615.1900285"]
[null,null,"Soggetti",null,"Pharmaceutical chemistry - Data processing"]
[{"$nulls":4},"Drugs - Design - Data processing"]
[{"$nulls":4},"Drugs - Research - Data processing"]
[{"$nulls":4},"QSAR (Biochemistry)"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Advanced Computer- Assisted Techniques in Drug Discovery; Preface; A Personal Foreword; Contents; 1 Introduction; 1.1 3D QSAR; 1.2 Databases; 1.3 Progress in Multivariate Data Analysis; 1.4 Scope of this Book; References; 2 3D QSAR: The Integration of QSAR with Molecular Modeling; 2.1 Chemometrics and Molecular Modeling; 2.1.1 Introduction; 2.1.2 QSAR Methodology using Molecular Modeling and Chemometrics; 2.1.2.1 Search for the Geometric Pharmacophore; 2.1.2.2 Quantitative Correlation between Molecular Properties and Activity; 2.1.2.3 Computer Programs; 2.1.3 Illustrative Examples"]
[{"$nulls":4},"2.1.3.1 Amnesia-Reversal Compounds2.1.3.2 Non-Peptide Angiotensin II Receptor Antagonists; 2.1.3.3 HMG-CoA Reductase Inhibitors; 2.1.3.4 Antagonists at the 5-HT3 Receptor; 2.1.3.5 Polychlorinated Dibenzo-p-dioxins; 2.1.4 Conclusions; References; 2.2 3D QSAR Methods; 2.2.1 Introduction; 2.2.2 3D QSAR of a Series of Calcium Channel Agonists; 2.2.2.1 Molecular Alignment; 2.2.2.2 Charges; 2.2.2.3 Generating 3D Fields; 2.2.2.4 Compilation of GRID Maps; 2.2.2.5 Inclusion of Macroscopic Descriptors with 3D Field Data; 2.2.3 Statistical Analysis; "]
[{"$nulls":4},"2.2.3.1 Results of the Analysis"]
[{"$nulls":4},"2.2.3.2 Testing the Model2.2.4 Conclusions; References; 2.3 GOLPE Philosophy and Applications in 3D QSAR; 2.3.1 Introduction; 2.3.1.1 3D Molecular Descriptors and Chemometric Tools; 2.3.1.2 Unfolding Three-way Matrices; 2.3.2 The GOLPE Philosophy; 2.3.2.1 Variable Selection; 2.3.3 Applications; 2.3.3.1 PCA on the Target Matrix; 2.3.3.2 PCA on the Probe Matrix; 2.3.3.3 PLS Analysis on the Target Matrix; 2.3.3.4 PLS on Target Matrix as a Strategy to Ascertain the Active Conformation; 2.3.3.5 GOLPE with Different 3D Descriptors; 2.3.4 Conclusions and Perspectives; References"]
[{"$nulls":4},"3 Rational Use of Chemical and Sequence Databases3.1 Molecular Similarity Analysis: Applications in Drug Discovery; 3.1.1 Introduction; 3.1.2 Similarity-Based Compound Selection; 3.1.2.1 Similarity Measures and Neighborhoods; 3.1.2.2 Application of 2D and 3D Similarity Measures; 3.1.2.3 Application of Dissimilarity-Based Compound Selection for Broad Screening; 3.1.3 Structure-Activity Maps (SAMs); 3.1.3.1 A Visual Analogy; 3.1.3.2 Representing Inter-Structure Distances; 3.1.3.3 Structure Maps; 3.1.3.4 Coloring a Structure Map; 3.1.4 Field-Based Similarity Methods"]
[{"$nulls":4},"3.1.4.1 Field-Based Similarity Measures3.1.4.2 Field-Based Molecular Superpositions; 3.1.4.3 An Example of Field-Based Fitting: Morphine and Clonidine; 3.1.5 Conclusions; References; 3.2 Clustering of Chemical Structure Databases for Compound Selection; 3.2.1 Introduction; 3.2.2 Review of Clustering Methods; 3.2.2.1 Hierarchical Clustering Methods; 3.2.2.2 Non-Hierarchical Clustering Methods; 3.2.3 Choice of Clustering Method; 3.2.3.1 Computational Requirements; 3.2.3.2 Cluster Shapes; 3.2.3.3 Comparative Studies"]
[{"$nulls":4},"3.2.4 Examples of the Selection of Compounds from Databases by Clustering Techniques"]
[null,null,null,"Sommario/riassunto","The use of powerful computers has revolutionized molecular design and drug discovery. Thoroughly researched and well-structured, this comprehensive handbook covers highly effective and efficient techniques in 3D-QSAR and advanced statistical analysis. The emphasis is on showing users how to apply these methods and avoid costly and time-consuming methodical errors.Topics covered include* combination of statistical methods and molecular modeling tools* rational use of databases* advanced statistical techniques* neural networks and expert systems in molecular design<br"]
[null,"2.","Record Nr.",null,"UNISA996465660803316"]
[null,null,"Titolo",null,"Analytical and Stochastic Modeling Techniques and Applications [[electronic resource] ] : 17th International Conference, ASMTA 2010, Cardiff, UK, June 14-16, 2010, Proceedings / / edited by Khalid Al-Begain, Dieter Fiems, William Knottenbelt"]
[null,null,"Pubbl/distr/stampa",null,"Berlin, Heidelberg : , : Springer Berlin Heidelberg : , : Imprint : Springer, , 2010"]
[null,null,"ISBN",null,"1-280-38710-6"]
[{"$nulls":4},"9786613565020"]
[{"$nulls":4},"3-642-13568-4"]
[null,null,"Edizione",null,"[1st ed. 2010.]"]
[null,null,"Descrizione fisica",null,"1 online resource (XI, 409 p. 132 illus.)"]
[null,null,"Collana",null,"Programming and Software Engineering, , 2945-9168 ; ; 6148"]
[null,null,"Disciplina",null,"004.6015118"]
[null,null,"Soggetti",null,"Software engineering"]
[{"$nulls":4},"Computer networks"]
[{"$nulls":4},"Electronic digital computers—Evaluation"]
[{"$nulls":4},"Application software"]
[{"$nulls":4},"Computer science—Mathematics"]
[{"$nulls":4},"Mathematical statistics"]
[{"$nulls":4},"Algorithms"]
[{"$nulls":4},"Software Engineering"]
[{"$nulls":4},"Computer Communication Networks"]
[{"$nulls":4},"System Performance and Evaluation"]
[{"$nulls":4},"Computer and Information Systems Applications"]
[{"$nulls":4},"Probability and Statistics in Computer Science"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Queueing Theory I -- A Batch-Service Queueing Model with a Discrete Batch Markovian Arrival Process -- Queueing System MAP/PH/N with Propagated Failures -- Analysis of a Discrete-Time Queueing System with an NT-Policy -- Packet Loss Minimization in Load-Balancing Switch -- Queueing Theory II -- The Preemptive Repeat Hybrid Server Interruption Model -- Networks of Symmetric Multi-class Queues with Signals Changing Classes -- Product-Form Solutions for Models with Joint-State Dependent Transition Rates -- The qnetworks Toolbox: A Software Package for Queueing Networks Analysis -- Specification "]
[{"$nulls":4},"Languages and Tools -- Rewriting Logic Based Performance Estimation of Embedded Systems -- A Formal Language toward the Unification of Model Checking and Performance Evaluation -- Security Evaluation of Layered Intrusion Tolerant Systems -- Stochastic PERT and CAST Logic Approach for Computer Support of Complex Operation Planning -- Telecommunication Systems I -- Perfect Sampling of Load Sharing Policies in Large Scale Distributed Systems -- Stochastic Comparisons for Performability of Telecommunication Systems -- Model-Based Stochastic Simulation of P2P VoIP Using Graph Transformation System -- Performance Evaluation of Media Segmentation Heuristics Using Non-markovian Multi-class Arrival Processes -- Telecommmunication Systems II -- A Formal Approach to Investigate the Performance of Modern E-commerce Services -- Leader Election in Anonymous Radio Networks: Model Checking Energy Consumption -- Upper Bound on Overall Delay in Wireless Broadband Networks with Non Real-Time Traffic -- Estimation -- Robustness of the Whittle Estimator Applied to Non-Gaussian Long-Range Dependent Processes -- Service Time Estimation with a Refinement Enhanced Hybrid Clustering Algorithm -- Invariant Embedding Technique and Its Applications for Improvement or Optimization of Statistical Decisions -- Prediction -- Prediction Model Selection and Spare Parts Ordering Policy for Efficient Support of Maintenance and Repair of Equipment -- Prediction-Based Dynamic Target Interception Using Discrete Markov Chains -- Neural Networks as Surrogate Models for Measurements in Optimization Algorithms -- Stochastic Modelling -- Limit Behavior of the Hybrid Approximation of Stochastic Process Algebras -- Analysis of an Automated Auction with Concurrent Multiple Unit Acceptance Capacity -- Congestive Collapse and Its Avoidance in a Dynamic Dial-a-Ride System with Time Windows."]
[null,"3.","Record Nr.",null,"UNINA9910131546403321"]
[null,null,"Autore",null,"Legendre Bertrand"]
[null,null,"Titolo",null,"Regards sur les petits éditeurs / / Bertrand Legendre"]
[null,null,"Pubbl/distr/stampa",null,"Paris, : Département des études, de la prospective et des statistiques, 2014"]
[null,null,"ISBN",null,"2-11-139870-5"]
[null,null,"Descrizione fisica",null,"1 online resource (12 p.)"]
[null,null,"Soggetti",null,"Business"]
[{"$nulls":4},"Cultural studies"]
[{"$nulls":4},"economics of culture and Communication"]
[{"$nulls":4},"cultural businesses"]
[{"$nulls":4},"publishing"]
[{"$nulls":4},"économie de la culture et de la communication"]
[{"$nulls":4},"édition"]
[{"$nulls":4},"entreprises culturelles"]
[{"$nulls":4},"maison d'édition"]
[{"$nulls":4},"marché"]
[{"$nulls":4},"choix éditoriaux"]
[null,null,"Lingua di pubblicazione",null,"Francese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Principalement fondées sur des enquêtes de terrain, ces études examinent la situation actuelle des petits éditeurs et établissent un bilan démographique des mouvements de création et de disparition de maisons d’édition entre 1988 et 2005. Elles décrivent notamment les conditions de fonctionnement de ces maisons, la spécificité de leurs choix éditoriaux et leurs difficultés d’accès au marché, tout en replaçant dans le contexte général de la profession les perspectives et les attentes de ces petites structures éditoriales.  These studies, which are based mainly on on-the-spot surveys, examine the present situation of small publishers and provide a “demographic” record of the birth and demise of publishing houses from 1988 to 2005. The studies describe the conditions under which these publishers operate, their individual editorial policies, their difficulties in penetrating the market, and set the prospects and hopes of these small publishing concerns "]
[{"$nulls":4},"within the general context of the trade."]
[null,"4.","Record Nr.",null,"UNINA9910778064803321"]
[null,null,"Autore",null,"Amkraut Brian <1969->"]
[null,null,"Titolo",null,"Between home and homeland [[electronic resource] ] : youth aliyah from Nazi Germany / / Brian Amkraut"]
[null,null,"Pubbl/distr/stampa",null,"Tuscaloosa, : University of Alabama Press, c2006"]
[null,null,"ISBN",null,"0-8173-8162-7"]
[null,null,"Descrizione fisica",null,"1 online resource (247 p.)"]
[null,null,"Collana",null,"Judaic studies series"]
[null,null,"Disciplina",null,"940.53/183508350943"]
[null,null,"Soggetti",null,"Jews - Germany - Migrations"]
[{"$nulls":4},"Jewish children in the Holocaust"]
[{"$nulls":4},"Zionism - Germany - History - 20th century"]
[{"$nulls":4},"Jews - Germany - Politics and government"]
[{"$nulls":4},"Germany Emigration and immigration History 20th century"]
[{"$nulls":4},"Palestine Emigration and immigration History 20th century"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. [207]-226) and index."]
[null,null,"Nota di contenuto",null,"1932 : the decisive year -- Spreading the word -- Emigration or welfare movement? -- After the pogrom -- Conflicts and resolutions."]
[null,null,null,"Sommario/riassunto","The emigration of Jewish teenagers to Palestine to escape Hitler's Germany.   While the future darkened for the Jews of Germany as Hitler and his followers assumed and consolidated power in Germany, a number of efforts, at first random, uncoordinated, and often at cross-purposes with one another, were set underway both within and without German cities to facilitate the departure of Jews. Among them was the organization, \"Youth Aliyah\" (aliyah refers to the Zionist goal of a homecoming for Jews in historic Israel). To this day Youth Aliyah is considered by Israelis as"]
[null,"5.","Record Nr.",null,"UNINA9910844901403321"]
[null,null,"Titolo",null,"Commentario al Codice dei contratti pubblici 2023 / a cura di Francesco Russo"]
[null,null,"Pubbl/distr/stampa",null,"Roma, : Legis Giuridica, c2023"]
[null,null,"ISBN",null,"9791255860020"]
[null,null,"Descrizione fisica",null,"912 p. ; 21 cm"]
[null,null,"Disciplina",null,"346.4502302638"]
[null,null,"Locazione",null,"FGBC"]
[null,null,"Collocazione",null,"VI Z 314"]
[null,null,"Lingua di pubblicazione",null,"Italiano"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","In cop.: Aggiornato alla Riforma 2023 D. Leg.vo 31/03/2023, n.36"]
[null,"6.","Record Nr.",null,"UNINA9910380744903321"]
[null,null,"Autore",null,"Koźmiński Andrzej K."]
[null,null,"Titolo",null,"The Balanced Development Index for Europe’s OECD countries, 1999–2017 / / by Andrzej K. Koźmiński, Adam Noga, Katarzyna Piotrowska, Krzysztof Zagórski"]
[null,null,"Pubbl/distr/stampa",null,"Cham : , : Springer International Publishing : , : Imprint : Springer, , 2020"]
[null,null,"ISBN",null,"3-030-39240-6"]
[null,null,"Edizione",null,"[1st ed. 2020.]"]
[null,null,"Descrizione fisica",null,"1 online resource (123 pages)"]
[null,null,"Collana",null,"SpringerBriefs in Economics, , 2191-5504"]
[null,null,"Disciplina",null,"338.94"]
[null,null,"Soggetti",null,"Development economics"]
[{"$nulls":4},"Europe—Economic conditions"]
[{"$nulls":4},"Economic policy"]
[{"$nulls":4},"Economics"]
[{"$nulls":4},"Development Economics"]
[{"$nulls":4},"European Economics"]
[{"$nulls":4},"Political Economy/Economic Systems"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,"Nota di contenuto",null,"Chapter 1: Introduction -- Chapter 2: GDP Shortcomings and a Brief History of Creating General Measures of Socio-Economic Development -- Chapter 3: Conceptual and Theoretical Basis of Balanced Development Index (BDI) -- Chapter 4: To Weight or Not to Weight? -- Chapter 5: Four Domains of Socio-Economic Development and their Indicators as BDI Components -- Chapter 6: International Differences in the Level and Pace of Socio-Economic Development -- Chapter 7: Chainges in BDI, its Four Components and GDP -- Chapter 8: BDI, Other Composite Measures of Socio-Economic Conditions and Happiness -- Chapter 9: Case Study: Poland -- Chapter 10: Emotional and Rational Countries -- Chapter 11: Development and Socio-Economic Balance -- Chapter 12: Conclusions."]
[null,null,null,"Sommario/riassunto","This book presents the Balanced Development Index (BDI), measuring socioeconomic development in twenty-two European OECD member countries in a period 1999-2017. Compared to other composite measures of development, BDI looks beyond traditional development indicators, such as GDP, to create an index which gives equal weight to social, economic, objective, and subjective aspects of development. The "]
[{"$nulls":4},"BDI aggregates forty-two detailed indicators into four composite middle-level indexes: external economic (characterizing functioning of national economies in their international surroundings), internal economic (characterizing various aspects of domestic economic conditions), social expectations (public hopes and fears concerning economic, political and social conditions), and current social condition (including both objective and subjective social indicators)—which are, in turn, aggregated into the general BDI index."]
[null,"7.","Record Nr.",null,"UNINA9910131790803321"]
[null,null,"Titolo",null,"The American journal of gastroenterology"]
[null,null,"Pubbl/distr/stampa",null,"[Amsterdam] ; [New York], : Elsevier"]
[{"$nulls":4},"[Malden, MA], : Blackwell"]
[{"$nulls":4},"[London], : Nature Pub. Group"]
[{"$nulls":4},"Nrew York, : Nature Pub. Group"]
[null,null,"ISSN",null,"1572-0241"]
[null,null,"Descrizione fisica",null,"1 online resource"]
[null,null,"Disciplina",null,"616.33"]
[null,null,"Soggetti",null,"Stomach - Diseases"]
[{"$nulls":4},"Intestines - Diseases"]
[{"$nulls":4},"Gastrointestinal system - Diseases"]
[{"$nulls":4},"Digestive organs"]
[{"$nulls":4},"Gastroenterology"]
[{"$nulls":4},"Gastrointestinal Diseases"]
[{"$nulls":4},"Intestins - Maladies"]
[{"$nulls":4},"Appareil digestif"]
[{"$nulls":4},"Estomac - Maladies"]
[{"$nulls":4},"Tractus gastro-intestinal - Maladies"]
[{"$nulls":4},"Gastro-enterologie"]
[{"$nulls":4},"Periodical"]
[{"$nulls":4},"periodicals."]
[{"$nulls":4},"Periodicals."]
[{"$nulls":4},"Périodiques."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Periodico"]
[null,null,null,"Note generali","Refereed/Peer-reviewed"]
[null,"8.","Record Nr.",null,"UNINA9910155288903321"]
[null,null,"Titolo",null,"Integrins and ICMA-1 in immune responses"]
[null,null,"Pubbl/distr/stampa",null,"[Place of publication not identified], : Karger, 1991"]
[null,null,"ISBN",null,"9783318018202"]
[{"$nulls":4},"3318018201"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (VIII + 168 pages) : :   21 figures, 11 tables"]
[null,null,"Collana",null,"Issn Series"]
[null,null,"Soggetti",null,"Immune System"]
[{"$nulls":4},"Disease"]
[{"$nulls":4},"Antigens, Surface"]
[{"$nulls":4},"Blood Cells"]
[{"$nulls":4},"Membrane Glycoproteins"]
[{"$nulls":4},"Receptors, Immunologic"]
[{"$nulls":4},"Glycoproteins"]
[{"$nulls":4},"Antigens"]
[{"$nulls":4},"Blood"]
[{"$nulls":4},"Membrane Proteins"]
[{"$nulls":4},"Hemic and Immune Systems"]
[{"$nulls":4},"Cells"]
[{"$nulls":4},"Receptors, Cell Surface"]
[{"$nulls":4},"Anatomy"]
[{"$nulls":4},"Proteins"]
[{"$nulls":4},"Biological Factors"]
[{"$nulls":4},"Amino Acids, Peptides, and Proteins"]
[{"$nulls":4},"Chemicals and Drugs"]
[{"$nulls":4},"Leukocytes"]
[{"$nulls":4},"Cell Adhesion Molecules"]
[{"$nulls":4},"Integrins"]
[{"$nulls":4},"Neoplasms"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,"Nota di contenuto",null,"CIA199105000I.PDF.pdf -- CIA1991050001 -- CIA1991050013 -- CIA1991050034 -- CIA1991050055 -- CIA1991050075 -- "]
[{"$nulls":4},"CIA1991050089 -- CIA1991050098 -- CIA1991050116 -- CIA1991050135 -- CIA1991050143 -- CIA1991050165."]