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[null,"1.","Record Nr.",null,"UNINA9910144010103321"]
[null,null,"Titolo",null,"Iron metabolism : inorganic biochemistry and regulatory mechanisms / / edited by Gloria C. Ferreira, José J. G. Moura, Ricardo Franco"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim, Germany : , : Wiley-VCH, , 1999"]
[{"$nulls":4},"©1999"]
[null,null,"ISBN",null,"1-281-84248-6"]
[{"$nulls":4},"9786611842482"]
[{"$nulls":4},"3-527-61370-6"]
[{"$nulls":4},"3-527-61371-4"]
[null,null,"Descrizione fisica",null,"1 online resource (412 p.)"]
[null,null,"Disciplina",null,"572.517"]
[{"$nulls":4},"572.5174"]
[{"$nulls":4},"572/.5174"]
[null,null,"Soggetti",null,"Iron - Metabolism"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Includes index."]
[null,null,"Nota di contenuto",null,"Iron Metabolism; Contents; Iron Metabolism Regulation and Iron Storage; Iron and Regulation of Heme Biosynthesis; 1 Iron-dependent regulation of bacterial heme biosynthesis; 1.1 Introduction; 1.2 Summary of heme biosynthetic pathways; 1.3 Mediators of iron-dependent regulation of iron metabolism; 1.4 Regulation of heme synthesis by iron; 2  5-Aminolevulinate synthase and mammalian heme biosynthesis; 2.1 Introduction: 5-aminolevulinate synthase and iron; 2.2 Structure and mechanism: early studies; 2.2.1 Isolation, purification and identification of the PLP cofactor"]
[{"$nulls":4},"2.2.2 Steady-state kinetics and mechanism of ALAS2.3 Structure and function: the active site of ALAS; 2.3.1 Identification of the Schiff base linkage between PLP and lysine-313; 2.3.2 Role of a glycine-rich loop as a PLP cofactor-binding site; 2.3.3 Role of aspartate-279 in enhancing the function of PLP and in ALAS catalysis; 2.3.4 Role of tyrosine-121 in the PLP cofactor binding; 2.3.5 Role of arginine-439 in substrate binding; 2.3.6 Active site intersubunit arrangement; 2.4 Conclusions; 3 Ferrochelatase: a new iron sulfur center-containing enzyme; 3.1 Introduction"]
[{"$nulls":4},"3.2 Identification, purification and characterization of ferrochelatase3.3 Steady-state kinetic properties of ferrochelatase; 3.3.1 Ferrochelatase "]
[{"$nulls":4},"reaction mechanism; 3.3.2 Reducing conditions are not essential for ferrochelatase activity; 3.3.3 Site-directed mutagenesis; 3.3.4 Iron-substrate ligands as determined by Mossbauer spectroscopy; 3.4 The [2Fe-2S] cluster of mammalian ferrochelatases; 3.4.1 Conserved cysteines and iron-sulfur cluster binding; 3.4.2 Spectroscopic characterization of the [2Fe-2S] cluster; 3.5 The three-dimensional structure of Bacillus subtilis ferrochelatase"]
[{"$nulls":4},"3.6 ConclusionsRegulation of Iron Transport and Metabolism; 4 The biochemistry and molecular biology of iron metabolism in yeast; 4.1 Introduction; 4.2 Iron transport in Saccharomyces cerevisiae; 4.2.2 Identification of FET3; 4.2.3 Fet3p is a multicopper oxidase; 4.2.4 Fet3p acts as a ferroxidase to mediate iron transport; 4.3 Oxidase-permease based iron transport systems in other species; 5 Role of redox-active metals in the regulation of the metallothionein and heme oxygenase genes by heme and hemopexin; 5.1 Introduction; 5.2 Hemopexin; 5.2.1 Structure; 5.3 Tissue expression of hemopexin"]
[{"$nulls":4},"5.3.1 Liver5.3.2 Barrier tissues; 5.4 Heme- and heme-hemopexin-mediated effects; 5.4.1 Target tissues; 5.4.2 Responses; 5.4.2.1 Interactions between the hemopexin and transferrin systems; 5.5 Biochemical and cellular consequences of heme-hemopexin: comparison with free heme; 5.5.1 Protective role of hemopexin; 5.5.2 Increased oxidation state; 5.5.3 Transcription factors; 5.5.3.1 Redox sensitive; 5.5.3.2 For metallothionein regulation; 5.5.4 Links between iron and copper in iron homeostasis; 5.5.6 Links between heme and copper and cellular homeostasis"]
[{"$nulls":4},"5.5.6.1 Role of copper in certain of the cellular and regulatory effects of hemopexin: intracellular oxidation state"]
[null,null,null,"Sommario/riassunto","Iron plays a crucial role in many biochemical processes. In recent years intensive research has led to a better understanding of the function of iron in cellular metabolism. In more than twenty articles internationally renowned experts give a thorough account of the recent developments of this fascinating field. The book focuses on the central questions, e.g. transport, storage, and utilization of iron in cells, the three-dimensional structure of iron-containing proteins, the physiological function of heme and iron sulfur-containing proteins, and the regulatory mechanisms in heme biosynthesis"]
[null,"2.","Record Nr.",null,"UNINA9910788099603321"]
[null,null,"Autore",null,"Bae-Harboe Yoon-Soo Cindy"]
[null,null,"Titolo",null,"Vascular Lesions of the Head and Neck : Diagnosis and Management / / by: Persky, Mark S., Waner, Milton, Blei, Francine, Berenstein, Alejandro"]
[null,null,"Pubbl/distr/stampa",null,"New York, New York : , : Thieme, , 2015"]
[{"$nulls":4},"©2015"]
[null,null,"ISBN",null,"1-63853-066-1"]
[{"$nulls":4},"1-62623-087-0"]
[null,null,"Descrizione fisica",null,"1 online resource (172 p.)"]
[null,null,"Disciplina",null,"616.8/1"]
[null,null,"Soggetti",null,"Diagnosis, Differential"]
[{"$nulls":4},"Hemangiomas"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references at the end of each chapters and index."]
[null,null,"Nota di contenuto",null,"Vascular Lesions of the Head and Neck: Diagnosis and Management; Title Page; Copyright; Dedication; Contents; Foreword; Preface; Acknowledgments; Contributors; 1 Classification of Vascular Anomalies; 2 Congenital Vascular Tumors; 3 Pathology of Congenital Vascular Lesions; 4 The Natural History, Physical Findings, and Evaluation of Hemangiomas; 5 Hemangioma Syndromes; 6 Radiologic Evaluation of Hemangiomas; 7 Medical Management of Hemangiomas; 8 Treatment of Infantile Hemangiomas; 9 Radiologic Evaluation of Vascular Malformations"]
[{"$nulls":4},"10 The Role of Endovascular Surgery in the Management of Vascular Lesions of the Head and Neck11 Treatment of Port-Wine Stains; 12 The Surgical Management of Vascular Malformations; 13 Evaluation and Treatment of Vascular Neoplasms; 14 Pathology of Acquired Vascular Neoplasms of the Head and Neck; Index"]
[null,null,null,"Sommario/riassunto","Vascular Lesions of the Head and Neck provides readers with an up-to-date review of the pathology, basic science, classification, radiologic features, and treatment modalities for vascular lesions of the head and neck. It covers all recent developments in medical and surgical treatment, laser technology, endovascular techniques, and appropriate radiation protocols that dramatically affect the evaluation and management of patients with vascular lesions. This book is an excellent desk reference for all otolaryngologists, plastic surgeons, vascular "]
[{"$nulls":4},"interventional radiologists, pediatricians, derm"]