{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":25,"n_cols":5,"rows_kept":25,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[3,2,3,3],[8,2,8,3],[9,2,9,3],[10,2,10,3],[11,2,11,3],[13,2,13,3],[14,2,14,3],[17,2,17,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910143748603321"]
[null,null,"Titolo",null,"Recent advances in quantitative methods for cancer and human health risk assessment [[electronic resource] /] / edited by Lutz Edler, Christos P. Kitsos"]
[null,null,"Pubbl/distr/stampa",null,"Chichester, England ; ; Hoboken, N.J., : J. Wiley, c2005"]
[null,null,"ISBN",null,"1-280-28775-6"]
[{"$nulls":4},"9786610287758"]
[{"$nulls":4},"0-470-30008-6"]
[{"$nulls":4},"0-470-85770-6"]
[{"$nulls":4},"0-470-85766-8"]
[null,null,"Descrizione fisica",null,"1 online resource (504 p.)"]
[null,null,"Collana",null,"Wiley series in probability and statistics"]
[null,null,"Disciplina",null,"616.994071015118"]
[null,null,"Soggetti",null,"Cancer - Risk factors - Mathematical models"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,"Nota di contenuto",null,"Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment; Contents; Contributors; Preface; Introduction; I CANCER AND HUMAN HEALTH RISK ASSESSMENT Introductory remarks; 1. Principles of Cancer Risk Assessment: The Risk Assessment Paradigm; 1.1 The risk assessment paradigm; 1.2 Hazard identification; 1.3 Dose-response assessment; 1.3.1 Different objectives, different data sets, different approaches; 1.3.2 Extrapolations in dose-response assessment; 1.3.3 Safety assessment; 1.3.4 Modelling to estimate risk at low doses; 1.3.5 Uncertainty and human variation"]
[{"$nulls":4},"II BIOLOGICAL ASPECTS OF CARCINOGENESIS Introductory remarks2. Molecular Epidemiology in Cancer Research; 2.1 Introduction; 2.2 From carcinogen exposure to cancer; 2.3 Biomarkers; 2.3.1 Biomarkers of exposure; 2.3.2 Biomarkers of susceptibility; 2.3.3 Biomarkers of effect; 2.4 Validation of biomarkers; 2.4.1 Study design; 2.4.2 Genetic and statistical analysis; 2.4.3 Sample size requirements; 2.4.4 Sources of potential bias; 2.5 Factors influencing cancer risk; 2.5.1 Environmental factors; 2.5.2 Genetic factors; 2.5.3 Carcinogen metabolism; 2.5.4 DNA repair; 2.5.5 Cell cycle control"]
[{"$nulls":4},"2.5.6 Immune status2.6 New tools in molecular epidemiology; 2.6.1 Microarrays and toxicogenomics; 2.6.2 Proteomics; 2.6.3 Promising "]
[{"$nulls":4},"directions for cancer diagnosis and cancer biomarker discovery; 2.7 Conclusions; 3. Genetic Polymorphisms in Metabolising Enzymes as Lung Cancer Risk Factors; 3.1 Introduction; 3.1.1 Studies investigating genetic polymorphisms as lung cancer risk factors; 3.2 Methodological aspects; 3.2.1 Planning of the study; 3.2.2 Laboratory analyses; 3.2.3 Statistical analyses; 3.3 Examples; 3.3.1 N-Acetyltransferases (NAT1 and NAT2) and lung cancer risk"]
[{"$nulls":4},"3.3.2 Glutathione-S-transferases and lung cancer risk3.3.3 Myeloperoxidase and lung cancer risk; 3.3.4 CYP3A4 and CYP3A5 and lung cancer risk; 3.4 Discussion; Acknowledgements; 4. Biological Carcinogenesis: Theories and Models; 4.1 Introduction; 4.2 Models of human carcinogenesis; 4.2.1 Prostate cancer; 4.2.2 Colorectal cancer; 4.2.3 Endometrial cancer; 4.3 The multistage mouse skin carcinogenesis model; 4.4 Epilogue; 5. Biological and Mathematical Aspects of Multistage Carcinogenesis; 5.1 Introduction; 5.2 Features of multistage carcinogenesis; 5.2.1 Colorectal cancer"]
[{"$nulls":4},"5.2.2 The role of genomic instability in colon cancer5.2.3 Barrett's esophagus; 5.2.4 Intermediate lesions; 5.3 Generalized TSCE model; 5.3.1 Model building; 5.3.2 Mathematical development and the hazard function; 5.4 Modeling cancer incidence; 5.4.1 Age-cohort-period models; 5.4.2 Age-specific incidence; 5.4.3 Colorectal cancer in the SEER registry; 5.4.4 Analysis of occupational cohort data; 5.5 Summary; 6. Risk Assessment and Chemical and Radiation Hormesis: A Short Commentary and Bibliographic Review; 6.1 Introduction; 6.2 The concept of hormesis; 6.3 Chemical hormesis"]
[{"$nulls":4},"6.3.1 The -shaped and -shaped dose-response curve"]
[null,null,null,"Sommario/riassunto","Human health risk assessment involves the measuring of risk of exposure to disease, with a view to improving disease prevention. Mathematical, biological, statistical, and computational methods play a key role in exposure assessment, hazard assessment and identification, and dose-response modelling. Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment is a comprehensive text that accounts for the wealth of new biological data as well as new biological, toxicological, and medical approaches adopted in risk assessment. It provides an authoritative compendiu"]