{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":41,"n_cols":5,"rows_kept":41,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[3,2,3,3],[12,2,12,3],[13,2,13,3],[14,2,14,3],[15,2,15,3],[22,2,22,3],[25,2,25,3],[34,2,34,3],[35,2,35,3],[39,2,39,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910141446103321"]
[null,null,"Titolo",null,"Protein-ligand interactions / / edited by Holger Gohlke"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim, : Wiley-VCH, 2012"]
[null,null,"ISBN",null,"9786613639820"]
[{"$nulls":4},"9783527645961"]
[{"$nulls":4},"3527645969"]
[{"$nulls":4},"9781280662898"]
[{"$nulls":4},"1280662891"]
[{"$nulls":4},"9783527645947"]
[{"$nulls":4},"3527645942"]
[{"$nulls":4},"9783527645978"]
[{"$nulls":4},"3527645977"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (361 p.)"]
[null,null,"Collana",null,"Methods and principles in medicinal chemistry ; ; v. 53"]
[null,null,"Classificazione",null,"CHE 802f"]
[{"$nulls":4},"CHE 820f"]
[{"$nulls":4},"CHE 825f"]
[{"$nulls":4},"540"]
[{"$nulls":4},"570"]
[{"$nulls":4},"610"]
[{"$nulls":4},"WD 5100"]
[null,null,"Disciplina",null,"572.6"]
[{"$nulls":4},"572/.6"]
[{"$nulls":4},"615.19"]
[null,null,"Soggetti",null,"Proteins"]
[{"$nulls":4},"Ligands (Biochemistry)"]
[{"$nulls":4},"Ligand binding (Biochemistry)"]
[{"$nulls":4},"Drugs - Structure-activity relationships"]
[{"$nulls":4},"Carrier proteins"]
[{"$nulls":4},"Ligands"]
[{"$nulls":4},"Proteins - pharmacokinetics"]
[{"$nulls":4},"Chemistry Techniques, Analytical - methods"]
[{"$nulls":4},"Carrier Proteins"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"pt. 1. Binding thermodynamics -- pt. 2. Learning from biophysical experiments -- pt. 3. Modeling protein-ligand interactions -- pt. 4. Challenges in molecular recognition."]
[null,null,null,"Sommario/riassunto","Innovative and forward-looking, this volume focuses on recent achievements in this rapidly progressing field and looks at future potential for development.The first part provides a basic understanding of the factors governing protein-ligand interaction, followed by a comparison of the four key experimental methods (calorimetry, surface plasmon resonance, NMR and X-ray crystallography) used in generating interaction data. The second half of the book is devoted to in-silico methods of modeling and predicting molecular recognition and binding. Here, as elsewhere in the book, emphasis is place"]