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[null,"1.","Record Nr.",null,"UNINA9910140832103321"]
[null,null,"Titolo",null,"Aggregation of therapeutic proteins [[electronic resource] /] / edited by Wei Wang, Christopher J. Roberts"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, NJ, : Wiley, c2010"]
[null,null,"ISBN",null,"1-118-04358-8"]
[{"$nulls":4},"1-282-70798-1"]
[{"$nulls":4},"9786612707988"]
[{"$nulls":4},"0-470-76982-3"]
[{"$nulls":4},"0-470-76981-5"]
[null,null,"Descrizione fisica",null,"1 online resource (514 p.)"]
[null,null,"Disciplina",null,"615.5/8"]
[null,null,"Soggetti",null,"Protein drugs"]
[{"$nulls":4},"Aggregation (Chemistry)"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references  and index."]
[null,null,"Nota di contenuto",null,"AGGREGATION OF THERAPEUTIC PROTEINS; CONTENTS; PREFACE; CONTRIBUTORS; CHAPTER 1: Fundamental Structures and Behaviors of Proteins; CHAPTER 2: Protein Aggregation Pathways, Kinetics, and Thermodynamics; CHAPTER 3: Identification and Impact of Aggregation-Prone Regions in Proteins and Therapeutic Monoclonal Antibodies; CHAPTER 4: External Factors Affecting Protein Aggregation; CHAPTER 5: Experimental Detection and Characterization of Protein Aggregates; CHAPTER 6: Approaches to Control Protein Aggregation during Bulk Production"]
[{"$nulls":4},"CHAPTER 7: Protein Aggregation and Particle Formation: Effects of Formulation, Interfaces, and Drug Product Manufacturing OperationsCHAPTER 8: Approaches to Managing Protein Aggregation in Product Development; CHAPTER 9: Case Studies Involving Protein Aggregation; CHAPTER 10: Aggregation and Immunogenicity of Therapeutic Proteins; CHAPTER 11: Regulatory Perspective on Aggregates as a Product Quality Attribute; INDEX; color plate"]
[null,null,null,"Sommario/riassunto","This book gives pharmaceutical scientists an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. While significant progress has been made in the past decade, the current understanding of protein aggregation and its consequences is still immature. "]
[{"$nulls":4},"Prevention or even moderate inhibition of protein aggregation has been mostly experimental. The knowledge in this book can greatly help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this ar"]
[null,"2.","Record Nr.",null,"UNINA9910782411903321"]
[null,null,"Autore",null,"Ackerman Eugene <1920->"]
[null,null,"Titolo",null,"Mathematical models in the health sciences [[electronic resource] ] : a computer-aided approach / / Eugene Ackerman, Laël Cranmer Gatewood"]
[null,null,"Pubbl/distr/stampa",null,"Minneapolis, : University of Minnesota Press, c1979"]
[null,null,"ISBN",null,"0-8166-6826-4"]
[{"$nulls":4},"0-8166-6111-1"]
[null,null,"Descrizione fisica",null,"1 online resource (372 p.)"]
[null,null,"Disciplina",null,"610/.28/54"]
[null,null,"Soggetti",null,"Medicine - Mathematical models"]
[{"$nulls":4},"Medicine - Data processing"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographies and index."]
[null,null,"Nota di contenuto",null,"Preface; Contents; INTRODUCTION; DETERMINISTIC MODELS; TIME SERIES; INFORMATION AND SIMULATION; OVERVIEW; Index"]
[null,null,null,"Sommario/riassunto","This book, designed especially for use in graduate courses in the health sciences, will be useful also as a reference work for scientists in various disciplines. It provides an introduction to mathematical modeling through the use of selected examples from the health sciences. Where appropriate, computer techniques are discussed and illustrated with examples drawn from studies by the authors and their colleagues. An introductory chapter discusses mathematical models and their roles in biomedical research. The rest of the material is divided in three sections of four chapters each: Deterministi"]