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[null,"1.","Record Nr.",null,"UNINA9910140620103321"]
[null,null,"Titolo",null,"Vanilloid receptor TRPV1 in drug discovery : targeting pain and other pathological disorders / / edited by Arthur Gomtsyan, Connie R. Faltynek"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, NJ, : Wiley, c2010"]
[null,null,"ISBN",null,"1-282-55159-0"]
[{"$nulls":4},"9786612551598"]
[{"$nulls":4},"0-470-58828-4"]
[{"$nulls":4},"0-470-58827-6"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (486 p.)"]
[null,null,"Disciplina",null,"615.783"]
[{"$nulls":4},"615/.783"]
[null,null,"Soggetti",null,"Analgesics"]
[{"$nulls":4},"Drugs - Design"]
[{"$nulls":4},"Nociceptors"]
[{"$nulls":4},"Inflammation"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"VANILLOID RECEPTOR TRPV1 IN DRUG DISCOVERY; CONTENTS; PREFACE AND ACKNOWLEDGMENTS; FOREWORD; CONTRIBUTORS; PART I INTRODUCTION TO THE TRP CHANNELS; 1 TRP Channels and Human Diseases; 2 Role of TRP Channels in Pain: An Overview; 3 Biochemical Pharmacology of TRPV1: Molecular Integrator of Pain Signals; 4 TRPV1 Genetics; PART II ROLE FOR TRPV1 IN PAIN STATES; 5 TRPV1 and Inflammatory Pain; 6 Role of TRPV1 Receptors in Osteoarthritic Pain; 7 TRPV1 and Bone Cancer Pain; 8 TRPV1 in Visceral Pain and Other Visceral Disorders; 9 TRPV1 Receptors and Migraine"]
[{"$nulls":4},"10 TRPV1 in Neuropathic Pain and Neurological and Neuropsychiatric Disorders PART III TRPV1 ANTAGONISTS AND AGONISTS AS NOVEL ANALGESIC DRUGS; 11 Aryl-Urea Class and Related TRPV1 Antagonists; 12 2-Pyridinylpiperazine Carboxamide Class and Related TRPV1 Antagonists; 13 TRPV1 Agonist Approaches for Pain Management; PART IV ROLE FOR TRPV1 IN OTHER PHYSIOLOGICAL PROCESSES BESIDES PAIN TRANSMISSION; 14 The TRPV1 Channel in Normal Thermoregulation: What Have We Learned from Experiments Using Different Tools?; 15 The Role of TRPV1 in Respiratory Diseases; 16 The Role of TRPV1 in "]
[{"$nulls":4},"Diabetes; AFTERWORD"]
[{"$nulls":4},"INDEX"]
[null,null,null,"Sommario/riassunto","Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it \"\"the holy grail\"\" of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1"]