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[null,"1.","Record Nr.",null,"UNINA9910140501703321"]
[null,null,"Titolo",null,"Vaccine development and manufacturing / / edited by Emily P. Wen, Ronald Ellis, Narahari S. Pujar ; Michel Chartrain [and thirty one others], contributors"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, New Jersey : , : Wiley, , 2015"]
[{"$nulls":4},"©2015"]
[null,null,"ISBN",null,"1-78684-221-1"]
[{"$nulls":4},"1-118-87090-5"]
[{"$nulls":4},"1-118-87091-3"]
[{"$nulls":4},"1-118-87092-1"]
[null,null,"Descrizione fisica",null,"1 online resource (1044 p.)"]
[null,null,"Collana",null,"Wiley Series in Biotechnology and Bioengineering"]
[null,null,"Disciplina",null,"615.3/72"]
[null,null,"Soggetti",null,"Vaccines"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references at the end of each chapters and index."]
[null,null,"Nota di contenuto",null,"Cover; Series; Title Page; Copyright; Acknowledgments; Preface; Contributors; Chapter 1: History of Vaccine Process Development; 1.1 Introduction; 1.2 Vaccines Bioprocess Evolution; 1.3 Live Attenuated and Inactivated Virus Vaccines; 1.4 Live or Whole-Killed Bacterial Vaccines; 1.5 Classical Subunit Vaccines; 1.6 Recombinant Subunit Vaccines; 1.7 Conjugate Vaccines; 1.8 Downstream Processing; 1.9 Vaccines for the Developing World: Large Volume, Low Cost, and Thermostable; 1.10 Summary; Acknowledgments; References"]
[{"$nulls":4},"Chapter 2: The Production of Plasmid DNA Vaccine in Escherichia coli: A Novel Bacterial-Based Vaccine Production Platform2.1 Introduction: E. coli in Vaccine Production; 2.2 Brief Overview of DNA Vaccines: Mechanisms and Methods of Vaccinations; 2.3 Current Status of DNA Vaccines; 2.4 Required Physical Properties of Plasmid DNA Vaccines; 2.5 Choice of E. coli Host Strain; 2.6 Factors Influencing Plasmid Stability; 2.7 Transformation, Selection of Producing Clones, and Cell Banking; 2.8 Production Process; 2.9 Requirements for Clinical Supplies; 2.10 Conclusions; References"]
[{"$nulls":4},"Chapter 3: Fungal Expression Systems for Vaccine Production3.1 Introduction; 3.2 Hepatitis B Vaccines; 3.3 Human Papillomavirus Vaccine; 3.4 Malaria Vaccine Candidates; 3.5 HIV Vaccine Candidates; "]
[{"$nulls":4},"3.6 Veterinary Vaccines; 3.7 Perspectives; 3.8 Concluding Remarks; Acknowledgments; References; Chapter 4: Novel Expression Systems for Vaccine Production; 4.1 Introduction; 4.2 Subunit Vaccines; 4.3 Expression Systems; 4.4 Novel Expression Systems; 4.5 Production of Recombinant Proteins in Plants; 4.6 Launch Vector System; 4.7 Conclusions; References; Chapter 5: Viral Vaccines Purification"]
[{"$nulls":4},"5.1 Introduction5.2 Process Tasks; 5.3 Conclusions and Outlook; Acknowledgments; Nomenclature; Abbreviations; References; Chapter 6: Protein Subunit Vaccine Purification; 6.1 Introduction; 6.2 Purification Technologies-Applications in Protein Subunit Vaccine Purification; 6.3 Purification Process Development and Scale-Up for Protein Subunit Vaccine; 6.4 Process Definition Studies; 6.5 Process Economy and Automation; 6.6 Application of Process Analytical Technology in Protein Purification; 6.7 Downstream Purification-An Outlook; References; Chapter 7: Conjugate Vaccine Production Technology"]
[{"$nulls":4},"7.1 Conjugate Vaccine Production Technology7.2 Preparation of Antigen and Carrier Protein; 7.3 Polysaccharide Size; 7.4 Activation and Coupling of Polysaccharide and Carrier Protein; 7.5 Characterization of the Conjugate; 7.6 Future Directions; References; Chapter 8: Stabilization and Formulation of Vaccines; 8.1 Introduction; 8.2 An Example of a Modern Vaccine Characterization Strategy; 8.3 A Comprehensive Approach to Vaccine Formulation in Practice; 8.4 Conclusions; References; Chapter 9: Lyophilization In Vaccine Processes; 9.1 Introduction; 9.2 Formulation; 9.3 Filling; 9.4 Lyophilization"]
[{"$nulls":4},"9.5 Equipment"]
[null,null,null,"Sommario/riassunto","Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high"]
[null,"2.","Record Nr.",null,"UNINA9910779541703321"]
[null,null,"Autore",null,"Waldman Tom <1956->"]
[null,null,"Titolo",null,"Not much left [[electronic resource] ] : the fate of liberalism in America / / Tom Waldman"]
[null,null,"Pubbl/distr/stampa",null,"Berkeley, : University of California Press, 2008"]
[null,null,"ISBN",null,"0-520-93286-2"]
[null,null,"Descrizione fisica",null,"1 online resource (286 p.)"]
[null,null,"Disciplina",null,"320.510973"]
[null,null,"Soggetti",null,"Liberalism - United States - History - 20th century"]
[{"$nulls":4},"Liberalism - United States - History - 21st century"]
[{"$nulls":4},"Presidents - United States - Election - History - 20th century"]
[{"$nulls":4},"Presidents - United States - Election - History - 21st century"]
[{"$nulls":4},"Political campaigns - United States - History - 20th century"]
[{"$nulls":4},"Political campaigns - United States - History - 21st century"]
[{"$nulls":4},"Popular culture - Political aspects - United States - History - 20th century"]
[{"$nulls":4},"Popular culture - Political aspects - United States - History - 21st century"]
[{"$nulls":4},"United States Politics and government 1945-1989"]
[{"$nulls":4},"United States Politics and government 1989-"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Front matter -- Contents -- Acknowledgments -- Introduction: Quiet Americans -- Chapter 1. In Locke's Step -- Chapter 2. Which Way Did The '60S Go? -- Chapter 3. Unhappy Together -- Chapter 4. 1968 In America -- Chapter 5. Curious About George -- Chapter 6. Modern Times -- Chapter 7. I Am Woman, Say It Loud -- Chapter 8. Sexual Positions -- Chapter 9. Out Of Time -- Chapter 10. Yesterday's Gone -- Chapter 11. Pulling To The Right -- Chapter 12. Blue Culture, Red Politics -- Chapter 13. Coming Home? -- Epilogue: Who Are You? -- Notes -- Suggested Reading -- Index"]
[null,null,null,"Sommario/riassunto","Tom Waldman's lively and sweeping assessment of the state of American liberalism begins with the political turbulence of 1968 and culminates with the 2006 takeover of Congress by the Democratic Party. Not Much Left: The Fate of Liberalism in America vividly demonstrates how the progressive and liberal wing of the Democratic Party helped end a war, won the civil rights battle, and paved the way "]
[{"$nulls":4},"for blacks, women, gays, and other minorities to achieve full citizenship. Through reportage, anecdotes, and analysis-particularly of the disastrous defeat of Democrat George McGovern in 1972-Waldman chronicles how the grand coalition that achieved so much in the 1960's began to self-destruct in the early 1970's. Citing the Republican recovery from Barry Goldwater's 1964 defeat, Waldman demonstrates how the two parties' very different reactions to electoral debacle account for recent Republican dominance and Democratic impotence. Assessing liberalism's fate through the Carter and Reagan presidencies, the defeat of Michael Dukakis in the 1988 presidential election, and the on-again, off-again liberalism of the Clinton years, Waldman then brings the discussion up to date with analysis of the 2008 presidential campaign."]