{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":34,"n_cols":5,"rows_kept":34,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[2,4,2,5],[3,2,3,3],[4,2,4,3],[11,2,11,3],[12,2,12,3],[13,2,13,3],[16,2,16,3],[22,2,22,3],[23,2,23,3],[26,2,26,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910139751303321"]
[null,null,"Autore",null,"Masella Roberta"]
[null,null,"Titolo",null,"Glutathione and sulfur amino acids in human health and disease / / Roberta Masella and Giuseppe Mazza"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, : Wiley, c2009"]
[null,null,"ISBN",null,"9786612278525"]
[{"$nulls":4},"9781282278523"]
[{"$nulls":4},"1282278525"]
[{"$nulls":4},"9780470475973"]
[{"$nulls":4},"0470475978"]
[{"$nulls":4},"9780470475966"]
[{"$nulls":4},"047047596X"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (626 p.)"]
[null,null,"Disciplina",null,"612.015756"]
[{"$nulls":4},"612.3/98"]
[{"$nulls":4},"612.398"]
[null,null,"Soggetti",null,"Glutathione - Psychological aspects"]
[{"$nulls":4},"Sulfur amino acids - Psychological aspects"]
[{"$nulls":4},"Glutathione - Therapeutic use"]
[{"$nulls":4},"Sulfur amino acids - Therapeutic use"]
[{"$nulls":4},"Glutathione - Metabolism"]
[{"$nulls":4},"Sulfur amino acids - Metabolism"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,"Nota di contenuto",null,"GLUTATHIONE AND SULFUR AMINO ACIDS IN HUMAN HEALTH AND DISEASE; CONTENTS; PREFACE; CONTRIBUTORS; I INTRODUCTION; 1 GLUTATHIONE AND THE SULFUR-CONTAINING AMINO ACIDS: AN OVERVIEW; 1.1 Introduction; 1.2 Why Sulfur-Containing Amino Acids?; 1.3 S-Adenosylmethionine, Nature's Wonder Cofactor; 1.4 Glutathione; 1.5 Taurine-the Second Essential Sulfur-Containing Amino Acid?; 1.6 Conclusions; Acknowledgments; References; II CHEMISTRY AND METABOLISM OF GSH AND SULFUR AMINO ACIDS; 2 SULFUR AMINO ACIDS CONTENTS OF DIETARY PROTEINS: DAILY INTAKE AND REQUIREMENTS; 2.1 Introduction"]
[{"$nulls":4},"2.2 Sulfur Amino Acids (SAA) Content of Dietary Protein2.3 Sulfur Amino Acid Intake; 2.4 Nutritional Requirement for Total Sulfur Amino "]
[{"$nulls":4},"Acids; 2.5 Conclusions; References; 3 CELLULAR COMPARTMENTALIZATION OF GLUTATHIONE; 3.1 Introduction; 3.2 Glutathione Content in Cells; References; 4 INTESTINAL METABOLISM OF SULFUR AMINO ACIDS; 4.1 Introduction; 4.2 Isotopic Approaches to Study Metabolism; 4.3 Evidence of Gut Sulfur Amino Acid Metabolism; 4.4 Other Key Players in Intestinal Sulfur Amino Acid Metabolism; 4.5 Cysteine in Redox Function and Oxidant Stress in the Gut"]
[{"$nulls":4},"4.6 Pathophysiology of Sulfur Amino Acid Metabolism in the GIT4.7 Conclusions; References; 5 HEPATIC SULFUR AMINO ACID METABOLISM; 5.1 Introduction; 5.2 Dietary Relation between Methionine and Cysteine; 5.3 Metabolic Relation between Hepatic Sulfur Amino Acids, B Vitamins, and Methyl Group Metabolism; 5.4 Regulation of Sulfur Amino Acid Metabolism and Related Metabolic Pathways in the Liver; 5.5 Impact of Physiologic and Nutritional Factors on Sulfur Amino Acid Metabolism; 5.6 Conclusions; References; III ANTIOXIDANT AND DETOXIFICATION ACTIVITIES"]
[{"$nulls":4},"6 GLUTATHIONE AND SULFUR CONTAINING AMINO ACIDS: ANTIOXIDANT AND CONJUGATION ACTIVITIES6.1 Introduction; 6.2 Reactive Oxygen Species and Antioxidants; 6.3 Glutathione Redox Cycle; 6.4 Regulation of GSH and Cysteine Levels; 6.5 Biotransformation; 6.6 ROS-Mediated Cellular Signaling; 6.7 Transcription Regulation of Antioxidant and Conjugation Enzymes; 6.8 Oxidative Stress and Diseases; References; 7 GLUTAREDOXIN AND THIOREDOXIN ENZYME SYSTEMS: CATALYTIC MECHANISMS AND PHYSIOLOGICAL FUNCTIONS; 7.1 Introduction; 7.2 General Characteristics of Glutaredoxins"]
[{"$nulls":4},"7.3 General Characteristics of Thioredoxins7.4 Glutaredoxin Mechanism of Action; 7.5 Thioredoxin Mechanism of Action; 7.6 Control of Grx Expression; 7.7 Control of Trx Expression in Mammalian Systems; 7.8 Cellular Functions of Grx; 7.9 Cellular Functions of Trx; 7.10 Reversible Sulfhydryl Oxidation and Disease; 7.11 Conclusions; References; 8 METHIONINE SULFOXIDE REDUCTASES: A PROTECTIVE SYSTEM AGAINST OXIDATIVE DAMAGE; 8.1 Introduction; 8.2 History of the Msr System; 8.3 MsrA and MsrB Protein Structure and Mechanism of Action; 8.4 Msr Reducing Requirement; 8.5 Other Members of the Msr Family"]
[{"$nulls":4},"8.6 The Msr System: Both a Repair Enzyme and a Scavenger of ROS"]
[null,null,null,"Sommario/riassunto","The complex roles of glutathione and sulfur amino acids in human health Glutathione (?-L-glutamyl-L-cysteinylglycine, GSH) is a major antioxidant acting as a free radical scavenger that protects the cell from reactive oxygen species (ROS). Sulfur amino acids (SAAs), such as methionine and cysteine, play a critical role in the maintenance of health. GSH depletion as well as alterations of SAA metabolism are linked to a host of disease states including liver cirrhosis, various pulmonary diseases, myocardial ischemia and reperfusion injury, aging, Parkinson's disease, Alzheimer's disease"]