{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":1,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":19,"n_cols":5,"rows_kept":19,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[3,2,3,3],[8,2,8,3],[9,2,9,3],[10,2,10,3],[12,2,12,3],[13,2,13,3],[17,2,17,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910139690003321"]
[null,null,"Titolo",null,"Therapeutic proteins [[electronic resource] ] : strategies to modulate their plasma half-lives / / edited by Roland Kontermann"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim, Germany, : Wiley-Blackwell, 2012"]
[null,null,"ISBN",null,"3-527-64478-4"]
[{"$nulls":4},"1-283-45422-X"]
[{"$nulls":4},"9786613454225"]
[{"$nulls":4},"3-527-64482-2"]
[{"$nulls":4},"3-527-64479-2"]
[null,null,"Descrizione fisica",null,"1 online resource (374 p.)"]
[null,null,"Disciplina",null,"615.3"]
[null,null,"Soggetti",null,"Protein drugs - Design"]
[{"$nulls":4},"Proteins - Therapeutic use"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"pt. 1. General information -- pt. 2. Half-life extension through chemical and post-translational modifications -- pt. 3. Half-life modulation involving recycling by the neonatal Fc receptor -- pt. 4. Half-life extension with pharmaceutical formulations."]
[null,null,null,"Sommario/riassunto","For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals."]