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[null,"1.","Record Nr.",null,"UNINA9910139607903321"]
[null,null,"Autore",null,"Boverhof Darrell R"]
[null,null,"Titolo",null,"Applications of Toxicogenomics in Safety Evaluation and Risk Assessment [[electronic resource]]"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, : Wiley, 2011"]
[null,null,"ISBN",null,"1-283-23966-3"]
[{"$nulls":4},"9786613239662"]
[{"$nulls":4},"1-118-00104-4"]
[{"$nulls":4},"1-118-00103-6"]
[null,null,"Descrizione fisica",null,"1 online resource (402 p.)"]
[null,null,"Disciplina",null,"616.042"]
[{"$nulls":4},"616/.042"]
[null,null,"Soggetti",null,"Genetic toxicology"]
[{"$nulls":4},"Health risk assessment"]
[{"$nulls":4},"Risk Assessment"]
[{"$nulls":4},"Toxicity testing"]
[{"$nulls":4},"Toxicogenetics"]
[{"$nulls":4},"Toxicology"]
[{"$nulls":4},"Pharmacogenetics"]
[{"$nulls":4},"Risk"]
[{"$nulls":4},"Risk Management"]
[{"$nulls":4},"Epidemiologic Measurements"]
[{"$nulls":4},"Organization and Administration"]
[{"$nulls":4},"Pharmacology"]
[{"$nulls":4},"Probability"]
[{"$nulls":4},"Genetics"]
[{"$nulls":4},"Public Health"]
[{"$nulls":4},"Health Occupations"]
[{"$nulls":4},"Statistics as Topic"]
[{"$nulls":4},"Biological Science Disciplines"]
[{"$nulls":4},"Biology"]
[{"$nulls":4},"Health Services Administration"]
[{"$nulls":4},"Environment and Public Health"]
[{"$nulls":4},"Natural Science Disciplines"]
[{"$nulls":4},"Health Care"]
[{"$nulls":4},"Health Care Evaluation Mechanisms"]
[{"$nulls":4},"Epidemiologic Methods"]
[{"$nulls":4},"Quality of Health Care"]
[{"$nulls":4},"Investigative Techniques"]
[{"$nulls":4},"Health Care Quality, Access, and Evaluation"]
[{"$nulls":4},"Health & Biological Sciences"]
[{"$nulls":4},"Toxicology & Public Health"]
[{"$nulls":4},"Electronic books."]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,"Nota di contenuto",null,"Contents; Preface; Contributors; 1 Toxicology, \"\"Omics\"\" Technologies, and Toxicogenomics: A Primer; 2 Introduction to Human Health Risk Assessment; 3 Practical Considerations for the Application of Toxicogenomics to Risk Assessment: Early Experience, Current Drivers, and a Path Forward; 4 Approaches and Practical Considerations for the Analysis of Toxicogenomics Data; 5 Genomics in Identifying Mutagenic Mode of Action in Carcinogenesis; 6 Application of Genomics for Predicting and Understanding the Mode of Action for Nongenotoxic Carcinogens; 7 Genomics in Characterizing Endocrine Toxicity"]
[{"$nulls":4},"8 Studying Organ-Specific Toxicity Using Gene-Expression Profiling9 Toxicogenomic Studies in Human Populations; 10 Toxicogenomics Applied to Ecological Risk Assessment; 11 Analysis of Transcriptomic Dose-Response Data for Toxicology and Risk Assessment; 12 Toxicogenomics as a Tool for Validating Animal to Human Extrapolations in Chemical Risk Assessment: Concepts, Applications, and Challenges; 13 Toxicogenomics and Animal Alternatives; 14 Toxicogenomics and the Regulatory Framework; 15 Standardization of Gene-Expression Information for the Safety Evaluation: Activities in Japan"]
[{"$nulls":4},"16 Applying Transcriptional Profiling in Drug Safety Evaluation17 Reframing the Risk Assessment Paradigm: Toward a Systems Biology Approach; Index"]
[null,null,null,"Sommario/riassunto","This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process - including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how tox"]