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[null,"1.","Record Nr.",null,"UNINA9910298333503321"]
[null,null,"Titolo",null,"The genetics of obesity / / Struan F.A. Grant, editor"]
[null,null,"Pubbl/distr/stampa",null,"New York : , : Springer, , 2014"]
[null,null,"ISBN",null,"1-4614-8642-4"]
[null,null,"Edizione",null,"[1st ed. 2014.]"]
[null,null,"Descrizione fisica",null,"1 online resource (viii, 128 pages) : color illustrations"]
[null,null,"Collana",null,"Gale eBooks"]
[null,null,"Disciplina",null,"599.935"]
[{"$nulls":4},"599935"]
[{"$nulls":4},"610"]
[{"$nulls":4},"611.01816"]
[null,null,"Soggetti",null,"Obesity - Genetic aspects"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Genetic Variation and Obesity Prior to the Era of Genome-Wide Association Studies -- Genetic Obesity Syndromes -- Genome-Wide Association Studies of Obesity -- Copy Number Variants and their Contribution to the Risk of Obesity -- Genetics of Childhood Obesity -- Genetic Pleiotropies of Obesity -- Functional Follow-up of Genetic Variants Using FTO as the Prime Example -- Index."]
[null,null,null,"Sommario/riassunto","In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity, but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO),  has been more robustly observed by others. Studies from both FTO knock out and FTO over expression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity.   Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book provides a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). The Genetics of Obesity covers this state of the art technology and its "]
[{"$nulls":4},"application to obesity in great detail. Topics include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants."]
[null,"2.","Record Nr.",null,"UNINA9910139604903321"]
[null,null,"Titolo",null,"Royal courts in dynastic states and empires : a global perspective / / edited by Jeroen Duindam, Tulay Artan, Metin Kunt"]
[null,null,"Pubbl/distr/stampa",null,"Leiden ; ; Boston, : Brill, c2011"]
[null,null,"ISBN",null,"1-283-16177-X"]
[{"$nulls":4},"9786613161772"]
[{"$nulls":4},"90-04-20623-X"]
[null,null,"Edizione",null,"[1st ed.]"]
[null,null,"Descrizione fisica",null,"1 online resource (xvi, 444 pages) : illustrations, maps"]
[null,null,"Collana",null,"Rulers & elites : comparative studies in governance ; ; v.1"]
[null,null,"Disciplina",null,"395.09"]
[null,null,"Soggetti",null,"Courts and courtiers - History"]
[{"$nulls":4},"Royal houses - History"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Includes index."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Preliminary Material / J. Duindam , T. Artan and M. Kunt -- Royal Courts In Dynastic States And Empires / Jeroen Duindam -- Pride, Pomp And Circumstance: Palace, Court And Household In Assyria 879–612 BCE / Gojko Barjamovic -- Hellenistic Court Society: The Seleukid Imperial Court Under Antiochos The Great, 223–187 BCE / Rolf Strootman -- The Roman Imperial Court: Seen And Unseen In The Performance Of Power / Andrew Wallace-Hadrill -- Court And State In The Roman Empire—Domestication And Tradition In Comparative Perspective / Peter Fibiger Bang -- Court And Capital In Byzantium / Paul Magdalino -- A King On The Move: The Place Of An Itinerant Court In Charlemagne’s Government / Rosamond McKitterick -- Court Historiography In Early Tang China: Assigning A Place To History And Historians At The Palace / Isenbike Togan -- To Be A Prince In The Fourth/Tenth-Century Abbasid Court / Nadia Maria El Cheikh -- Ceremonies And The City: The Court In Fourteenth-Century Constantinople / Ruth Macrides -- The Pope’s Household And Court In The Early Modern Age / Maria Antonietta Visceglia -- The Monarch And Inner-Outer Court Dualism In Late Imperial China / Sabine Dabringhaus -- Turks in the Ottoman Imperial Palace / O. Metin Kunt -- The Mughal Audience Hall: A Solomonic Revival Of Persepolis In The Form Of A Mosque / Ebba Koch -- Royal Weddings And The Grand Vezirate: Institutional And Symbolic Change In The Early Eighteenth Century / Tülay Artan -- Versailles, Vienna And Beyond: Changing Views Of "]
[{"$nulls":4},"Household And Government In Early Modern Europe / Jeroen Duindam -- Index / J. Duindam , T. Artan and M. Kunt."]
[null,null,null,"Sommario/riassunto","In recent decades the history of premodern states and empires has undergone major revision. At the heart of this process stood the court, encompassing the household as well as government institutions. This volume for the first time brings together the fruits of research on royal courts from antiquity to the modern world, from Asia to Europe. The authors are acknowledged specialists in their own fields, but they address themes relevant for all courts: the inner and outer dimensions of court architecture as well as staff organizations; the connections between court, capital, and realm; the relationship of the ruler with relatives and other elites. This volume pioneers comparative history combining a rich empirical orientation with a critical assessment of theoretical perspectives. This title is available online in its entirety in Open Access Contributors: Tülay Artan, Gojko Barjamovic, Peter Fibiger Bang, Jeroen Duindam, Sabine Dabringhaus, Nadia Maria El Cheikh, Ebba Koch, Metin Kunt, Paul Magdalino, Rosamond McKitterick, Ruth Macrides, Rolf Strootman, Isenbike Togan, Maria Antonietta Visceglia, and Andrew Wallace-Hadrill."]