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[null,"1.","Record Nr.",null,"UNISA996486172003316"]
[null,null,"Autore",null,"WEBSTER, James"]
[null,null,"Titolo",null,"Haydn's \"Farewell\" symphony and the idea of classical style : through-composition and cyclic integration in his instrumental music / James Webste"]
[null,null,"Pubbl/distr/stampa",null,"Cambridge [etc.], : Cambridge University Press, 1991"]
[null,null,"ISBN",null,"0-521-38520-2"]
[null,null,"Descrizione fisica",null,"Testo elettronico (PDF) (XIX, 402 p.) : mus."]
[null,null,"Collana",null,"Cambridge studies in music theory and analysis ; 1"]
[null,null,"Disciplina",null,"784.092"]
[null,null,"Soggetti",null,"Haydn, Franz Joseph Musica strumentale"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Risorsa elettronica"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Questo volume offre una nuova visione della musica strumentale di Joseph Haydn. Sostiene che molte delle opere strumentali più famose e caratteristiche di Haydn sono \"composte a fondo\", nel senso che i loro numerosi movimenti sono legati insieme in un ciclo. Questa integrazione ciclica è articolata, tra l'altro, dalla forma \"progressiva\" dei movimenti individuali, dai legami strutturali e gestuali tra i movimenti e dalle associazioni extramusicali. Al centro dello studio c'è un'analisi dettagliata e completa della Sinfonia \"Addio\", n. 45 in fa diesis minore (1772). L'analisi si distingue per l'uso sistematico di diversi metodi per chiarire la coerenza complessiva dell'opera. In un libro che mette in relazione sistematicamente i risultati dell'analisi e dell'interpretazione, Webster mette in discussione il concetto di \"stile classico\" che, secondo lui, ha distorto la nostra comprensione dello sviluppo di Haydn, e sottolinea la necessità di un maggiore apprezzamento della sua musica antica e della la sua statura come pari a Beethoven."]
[null,"2.","Record Nr.",null,"UNINA9910137205703321"]
[null,null,"Autore",null,"Chao Ma"]
[null,null,"Titolo",null,"Cancer immunotherapy & immuno-monitoring : mechanism, treatment, diagnosis, and emerging tools / / topic editors: Chao Ma, Rong Fan and Antoni Ribas"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2014"]
[{"$nulls":4},"Brazil : , : Frontiers Media SA, , 2014"]
[null,null,"ISBN",null,"9782889193806"]
[null,null,"Descrizione fisica",null,"1 online resource (97 pages) : illustrations; digital, PDF file(s)"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[null,null,"Soggetti",null,"Oncology"]
[{"$nulls":4},"Medicine"]
[{"$nulls":4},"Health & Biological Sciences"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,null,"Sommario/riassunto","In the past decade, significant progresses have taken place in the field of cancer immunotherapeutics. Tumor-targeting or adjuvant immunotherapies are being developed for most human cancers including melanoma, prostate cancer, glioblastoma, sarcoma, lung carcinoma and hepatocellular carcinoma. New immunotherapeutics, such as Ipilimumab (anti-CTLA-4), have finished human trials and are approved by the US Food and Drug Administration (FDA) for clinical treatment; cell-based immunotherapies such as adoptive cell transfer (ACT) have either been approved (i.e., sipuleucel-T) for the treatment of selected neoplastic malignancies or reached the stage of phase II/III clinical trials. Immunotherapetics has become a sophisticated field. Multimodal therapeutic regimens comprising several functional modules (up to 5 in the case of ACT) have been developed to provide more focused therapeutic responses with improved efficacy and reduced side effects. Despite the tremendous developments, a major challenge mains: the lack of effective and clinically-applicable methods. Due to the complex immunological responses of patients that involve both the organs with neoplastic lesion and the whole immune system, it is difficult to provide comprehensive assessment of therapeutic efficacy and mechanism in patients. Despite the rapid adaptation of advanced medical imaging modalities such as MRI and PET/CT scan and "]
[{"$nulls":4},"the gold standard pathological examination, there is still unmet demand in the clinic to best evaluate cancer-specific cellular immunity and functions. Flow cytometry analysis has modernized hematology and immunology, and is currently being adapted to clinical immune monitoring through a multi-center endeavour in the US. The study aims to normalize, standardize, and implement flow cytometry-based cellular immunity assay in routine clinical tests. In parallel, new technologies including single cell polyfunctional analysis and immunophenotyping microchip are being developed for rapid, informative, and longitudinal monitoring of immune response to anti-cancer treatment in the clinical settings, shedding new light to future clinical trials of cancer immunotherapies. These technologies were designed to address the major challenges caused by the complexity and functional heterogeneity of cancer biology and cellular immunity, and allow for comprehensive survey of both tumor and the immune system to identify their mechanistic interplay in response to cancer immunotherapy. In addition, new computational tools are required to integrate high dimensional data sets from comprehensive, single-cell level measurements of patient’s immune responses and render most accurate and definitive diagnostic decision facilitated by new immune monitoring tools. This new generation of informative, personalized clinical diagnostic tools will likely contribute to new understanding of therapy mechanism, pre-treatment stratification of patients, ongoing therapeutic monitoring and assessment."]
[null,"3.","Record Nr.",null,"UNINA9910404211303321"]
[null,null,"Autore",null,"David Bilchitz"]
[null,null,"Titolo",null,"Is This Seat Taken? Conversations at the Bar, the Bench and the Academy about the South African Constitution"]
[null,null,"Pubbl/distr/stampa",null,"Pretoria University Law Press (PULP), 2012"]
[null,null,"Descrizione fisica",null,"1 electronic resource (vii 446 p.)"]
[null,null,"Disciplina",null,"342.68"]
[null,null,"Soggetti",null,"Constitutional law - South Africa"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Now that economic development is starting to pick up in many countries in Africa, the question arises how such development can be balanced with the need for adequate environmental protection. This crucial issue, inherent in the notion of sustainable development, is addressed in this innovative and path-breaking volume. For the first time, academics from seventeen African countries have joined forces to analyse the way in which economic and environmental interests are balanced in their legal systems. The authors all use a common framework to improve the comparability of the country studies. The different country-related chapters do not only provide insights into the formally applicable legal rules (law in the books)., but given that the book brings together academics aware of the practice in Africa, they also describe the way in which environmental policy functions in practice (law in action). Many case studies, with conceptual analyses are provided of pollution incidents and the way in which administrative agencies or courts have on those occasions balanced the interests between the economy, society and the environment. A critical comparative analysis by the editors points at tendencies towards convergence and points of divergence between the African countries. Suggestions for policy reform are also formulated, showing African countries how they can benefit from experiences in the US and Europe.  This thought provoking volume is a must for anyone (academic, policymaker or practitioner) interested in sustainable development generally and in Africa in particular."]