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[null,"1.","Record Nr.",null,"UNINA9910136401403321"]
[null,null,"Autore",null,"Tarik Issad"]
[null,null,"Titolo",null,"30 years old : O-GlcNAc reaches age of reason - regulation of cell signaling and metabolism by O-GlcNAcylation / / edited by Tony Lefebvre and Tarik Issad"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2015"]
[{"$nulls":4},"Switzerland : , : Frontiers Media SA, , 2007-2015"]
[null,null,"ISBN",null,"9782889195916 (eboook)"]
[null,null,"Descrizione fisica",null,"1 online resource (113 pages) : illustrations"]
[null,null,"Collana",null,"Frontiers Research Topics"]
[null,null,"Disciplina",null,"572/.567"]
[null,null,"Soggetti",null,"Cell signalling"]
[{"$nulls":4},"Metabolism"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,null,"Sommario/riassunto","Hundreds post-translational modifications (PTM) were characterized among which a large variety of glycosylations including O-GlcNAcylation. Since its discovery, O-GlcNAcylation has emerged as an unavoidable PTM widespread in the living beings including animal and plant cells, protists, bacteria and viruses. In opposition to N- and O-glycosylations, O-GlcNAcylation only consists in the transfer of a single N-acetylglucosamine moiety through a beta-linkage onto serine and threonine residues of proteins confined within the cytosol, the nucleus and the mitochondria. The O-GlcNAc group is provided by UDP-GlcNAc, the end-product of the hexosamine biosynthetic pathway located at the crossroad of cell metabolisms making O-GlcNAcylation a PTM which level tightly reflects nutritional status; therefore regulation of cell homeostasis should be intimately correlated to lifestyle and environment. Like phosphorylation, with which it can compete, O-GlcNAcylation is reversible. This versatility is managed by OGT (O-GlcNAc transferase) that transfers the GlcNAc group and OGA (O-GlcNAcase) that removes it. Also, like its unsweetened counterpart, O-GlcNAcylation controls fundamental processes, e.g. protein fate, chromatin topology, DNA demethylation and, as recently revealed, circadian clock. Deregulation of O-GlcNAc dynamism may be involved in the emergence of cancers, neuronal and metabolic disorders such as Alzheimer's or diabetes respectively. This Research Topic in Frontiers in "]
[{"$nulls":4},"Endocrinology is the opportunity to celebrate the thirtieth anniversary of the discovery of \"O-GlcNAc\" by Gerald W. Hart."]