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[null,"1.","Record Nr.",null,"UNINA9910132397603321"]
[null,null,"Autore",null,"Selyanin M. A (Michael A.)"]
[null,null,"Titolo",null,"Hyaluronic acid : preparation, properties, application in biology and medicine / / Mikhail A. Selyanin, Petr Ya. Boykov and Vladimir N. Khabarov ; translated from the Russian version by scientific editor Felix Polyak"]
[null,null,"Pubbl/distr/stampa",null,"Chichester, England : , : Wiley, , 2015"]
[{"$nulls":4},"©2015"]
[null,null,"ISBN",null,"1-118-69595-X"]
[{"$nulls":4},"1-118-69593-3"]
[{"$nulls":4},"1-118-69592-5"]
[null,null,"Descrizione fisica",null,"1 online resource (215 p.)"]
[null,null,"Disciplina",null,"612.015782"]
[null,null,"Soggetti",null,"Hyaluronic acid"]
[{"$nulls":4},"Organic acids"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references at the end of each chapters and index."]
[null,null,"Nota di contenuto",null,"Title Page; Copyright Page; Contents; Foreword; Introduction; Chapter 1 The History of Hyaluronic Acid Discovery, Foundational Research and Initial Use; 1.1 Discovery; 1.2 Foundational Research; 1.3 Initial Medical Applications; 1.4 Sources of Hyaluronan; 1.5 Current Medical Study and Use; 1.6 Impact and Future Directions; References; Chapter 2 The Biological Role of Hyaluronic Acid; 2.1 Hyaluronic Acid Phylogenesis; 2.1.1 Polysaccharide Structure and the Problems of Phylogenesis; 2.1.2 Physico-Chemical and Functional Differences of Polysaccharides"]
[{"$nulls":4},"2.1.3 Biochemical Features of Hyaluronic Acid and Other Glycosaminoglycans2.2 Functions of Hyaluronan in Human Ontogenesis; 2.2.1 Role of Hyaluronic Acid in Fertilization; 2.2.2 Hyaluronan and Other Glucosaminoglycans in Cell Division, Migration and Differentiation; 2.2.3 Hyaluronic Acid and Sulfated Glycosaminoglycans in Maintaining a Differentiated Status of Cells; 2.2.4 Hyaluronan and Induction of Cellular Cycles for Differentiated Cells; 2.2.5 The Source of Hyaluronic Acid's Functional Properties and the Dynamics of its Synthesis and Degradation"]
[{"$nulls":4},"2.2.6 The Rules of Biopolymer Functional Cleavage2.3 Hyaluronan Signalling Systems; 2.4 Hyaluronan Functions in the Extracellular "]
[{"$nulls":4},"Matrix; 2.4.1 Extracellular Space; 2.4.2 Composition and Functioning of the Extracellular Matrix; 2.4.3 The Role of Hyaluronan in Transportation of Substances through the Extracellular Matrix: Diffusion, Osmosis, Electro-Osmosis and Vesicular Transportation; 2.4.4 Hyaluronan in the Extracellular Matrix of Different Connective Tissues; References; Chapter 3 Methods of Hyaluronic Acid Production; 3.1 Hyaluronan Sources and Extraction"]
[{"$nulls":4},"3.1.1 Hyaluronan Production from Animal Sources: General Methods3.1.2 Hyaluronan Purification; 3.1.3 The Chemical Production of Hyaluronan from Chicken Combs; 3.1.4 HA Production for Ophthalmology; 3.2 Bacterial Methods of Hyaluronic Acid Production; 3.3 Hyaluronan Destruction during Production, Storage and Sterilization; 3.4 Enzymatic Destruction of Hyaluronan; 3.4.1 Hyaluronidase Classification; 3.4.2 Properties and Functions of Hyaluronidases; 3.5 Non-Enzymatic Destruction of Hyaluronan; 3.5.1 Acid-Base Hydrolysis of Hyaluronan; 3.5.2 Oxidation-Reduction Depolymerization of Hyaluronan"]
[{"$nulls":4},"3.6 Quality of Hyaluronan Commercial Products of Animal and Bacterial OriginReferences; Chapter 4 Molecular and Supramolecular Structure of Hyaluronic Acid; 4.1 Primary Structure of Hyaluronic Acid; 4.2 Structure of Hyaluronan in Solution; 4.3 Rheological Properties of Hyaluronic Acid; References; Chapter 5 Chemical Modifications, Solid Phase, Radio-Chemical and Enzymatic Transformations of Hyaluronic Acid; 5.1 Main Characteristics of Cross-Linked Hydrogels; 5.2 Methods of Hyaluronic Acid Cross-Linking; 5.2.1 Cross-Linking with Carbodiimides; 5.2.2 Cross-Linking with Aldehydes"]
[{"$nulls":4},"5.2.3 Cross-Linking with Divinylsulfone"]
[null,null,null,"Sommario/riassunto","Hyaluronic acid is an essential part of connective, epithelialand neural tissues, and contributes to cell proliferation andmigration. It is used as a stimulating agent for collagen synthesisand is a common ingredient in skin-care products, a multi-billiondollar industry, as it is believed to be a key factor in fightingthe aging process.  Hyaluronic Acid: Production, Properties, Application inBiology and Medicine consists of six chapters discussing thevarious issues of hyaluronic acid research. In Chapter 1, ahistorical analysis recounts the discovery and milestones of theresearch leading to t"]