{"text_format":"2","workbook":"xls","n_sheets":1,"sheets":["report2"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":1,"defined_names":2,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900","formulas":"cached_only"}

{"sheet":"report2","index":0,"n_rows":46,"n_cols":5,"rows_kept":46,"cut":false,"hidden":false,"merged":[[0,2,0,3],[0,4,0,5],[1,2,1,3],[1,4,1,5],[2,2,2,3],[2,4,2,5],[3,2,3,3],[5,2,5,3],[8,2,8,3],[9,2,9,3],[10,2,10,3],[11,2,11,3],[12,2,12,3],[14,2,14,3],[15,2,15,3],[19,2,19,3],[27,2,27,3],[27,4,27,5],[28,2,28,3],[28,4,28,5],[29,2,29,3],[31,2,31,3],[33,2,33,3],[34,2,34,3],[35,2,35,3],[36,2,36,3],[38,2,38,3],[39,2,39,3],[43,2,43,3]],"flags":["formulas_cached_only"]}
[null,"1.","Record Nr.",null,"UNINA9910132350603321"]
[null,null,"Autore",null,"Saleh A. K. Md. Ehsanes"]
[null,null,"Titolo",null,"Statistical inference for models with multivariate t-distributed errors / / A. K. Md. Ehsanes Saleh, M. Arashi, S. M. M. Tabatabaey"]
[null,null,"Pubbl/distr/stampa",null,"Hoboken, New Jersey : , : John Wiley & Sons, , 2014"]
[{"$nulls":4},"©2014"]
[null,null,"ISBN",null,"1-118-85396-2"]
[{"$nulls":4},"1-118-85392-X"]
[{"$nulls":4},"1-118-85393-8"]
[null,null,"Edizione",null,"[1st edition]"]
[null,null,"Descrizione fisica",null,"1 online resource (275 p.)"]
[null,null,"Classificazione",null,"MAT029030MAT029010MAT029020"]
[null,null,"Disciplina",null,"519.536"]
[null,null,"Soggetti",null,"Regression analysis"]
[{"$nulls":4},"Multivariate analysis"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and indexes."]
[null,null,"Nota di contenuto",null,"Cover; Title Page; Copyright Page; CONTENTS; List of Figures; List of Tables; Preface; Glossary; List of Symbols; 1 Introduction; 1.1 Objective of the Book; 1.2 Models under Consideration; 1.2.1 Location Model; 1.2.2 Simple Linear Model; 1.2.3 ANOVA Model; 1.2.4 Parallelism Model; 1.2.5 Multiple Regression Model; 1.2.6 Ridge Regression; 1.2.7 Multivariate Model; 1.2.8 Simple Multivariate Linear Model; 1.3 Organization of the Book; 1.4 Problems; 2 Preliminaries; 2.1 Normal Distribution; 2.2 Chi-Square Distribution; 2.3 Student''s t-Distribution; 2.4 F-Distribution"]
[{"$nulls":4},"2.5 Multivariate Normal Distribution2.6 Multivariate t-Distribution; 2.6.1 Expected Values of Functions of M_t^(p)(η , σ^2V_p, γo) - Variables; 2.6.2 Sampling Distribution of Quadratic Forms; 2.6.3 Distribution of Linear Functions of t-Variables; 2.7 Problems; 3 Location Model; 3.1 Model Specification; 3.2 Unbiased Estimates of θ and σ^2 and Test of Hypothesis; 3.3 Estimators; 3.4 Bias and MSE Expressions of the Location Estimators; 3.4.1 Analysis of the Estimators of Location Parameter; 3.5 Various Estimates of Variance; 3.5.1 Bias and MSE Expressions of the Variance Estimators"]
[{"$nulls":4},"3.5.2 Analysis of the Estimators of the Variance Parameter3.6 Problems; 4 Simple Regression Model; 4.1 Introduction; 4.2 Estimation and Testing of η; 4.2.1 Estimation of η; 4.2.2 Test of Intercept Parameter; 4.2.3 Estimators of β and θ; 4.3 Properties of Intercept Parameter; 4.3.1 "]
[{"$nulls":4},"Bias Expressions of the Estimators; 4.3.2 MSE Expressions of the Estimators; 4.4 Comparison; 4.4.1 Optimum Level of Significance of θ_n^PT; 4.5 Numerical Illustration; 4.6 Problems; 5 ANOVA; 5.1 Model Specification; 5.2 Proposed Estimators and Testing; 5.3 Bias, MSE, and Risk Expressions; 5.4 Risk Analysis"]
[{"$nulls":4},"5.4.1 Comparison of θ_n and θ_n5.4.2 Comparison of θ_n_PT and θ_n(θ_n); 5.4.3 Comparison of θ_n^S, θ_n , θn, and θ_n^PT; 5.4.4 Comparison of θ_n^S and θ_n^S+; 5.5 Problems; 6 Parallelism Model; 6.1 Model Specification; 6.2 Estimation of the Parameters and Test of Parallelism; 6.2.1 Test of Parallelism; 6.3 Bias, MSE, and Risk Expressions; 6.3.1 Expressions of Bias, MSE Matrix, and Risks of β_n, Θ_n, β_n, and Θ_n; 6.3.2 Expressions of Bias, MSE Matrix, and Risks of the PTEs of β and Θ; 6.3.3 Expressions of Bias, MSE Matrix, and Risks of the SSEs of β and Θ"]
[{"$nulls":4},"6.3.4 Expressions of Bias, MSE Matrix, and Risks of the PRSEs of β and Θ6.4 Risk Analysis; 6.5 Problems; 7 Multiple Regression Model; 7.1 Model Specification; 7.2 Shrinkage Estimators and Testing; 7.3 Bias and Risk Expressions; 7.3.1 Balanced Loss Function; 7.3.2 Properties; 7.4 Comparison; 7.5 Problems; 8 Ridge Regression; 8.1 Model Specification; 8.2 Proposed Estimators; 8.3 Bias, MSE, and Risk Expressions; 8.3.1 Biases of the Estimators; 8.3.2 MSE Matrices and Risks of the Estimators; 8.4 Performance of the Estimators; 8.4.1 Comparison between β_n(k), β_n^S(k), and β_n^S+(k)"]
[{"$nulls":4},"8.4.2 Comparison between β_n (k) and β_n^PT (k)"]
[null,null,null,"Sommario/riassunto","\"This book summarizes the results of various models under normal theory with a brief review of the literature. Statistical Inference for Models with Multivariate t-Distributed Errors:  Includes a wide array of applications for the analysis of multivariate observations  Emphasizes the development of linear statistical models with applications to engineering, the physical sciences, and mathematics  Contains an up-to-date bibliography featuring the latest trends and advances in the field to provide a collective source for research on the topic  Addresses linear regression models with non-normal errors with practical real-world examples  Uniquely addresses regression models in Student's t-distributed errors and t-models  Supplemented with an Instructor's Solutions Manual, which is available via written request by the Publisher \"--"]
[null,"2.","Record Nr.",null,"UNINA9910788821103321"]
[null,null,"Titolo",null,"Animal cell biotechnology : in biologics production / / edited by Hansjörg Hauser, Roland Wagner"]
[null,null,"Pubbl/distr/stampa",null,"Berlin ; ; Boston : , : Walter de Gruyter GmbH & Company KG, , [2015]"]
[{"$nulls":4},"©2015"]
[null,null,"ISBN",null,"3-11-027896-0"]
[{"$nulls":4},"3-11-038142-7"]
[null,null,"Descrizione fisica",null,"1 online resource (718 p.)"]
[null,null,"Classificazione",null,"WX 6603"]
[null,null,"Disciplina",null,"660.6"]
[null,null,"Soggetti",null,"Animal cell biotechnology"]
[{"$nulls":4},"Pharmaceutical biotechnology"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references and index."]
[null,null,"Nota di contenuto",null,"Use and perspectives of animal cell culture / Roland Wagner, Hansjörg Hauser -- Generation of cell lines and biotechnological applications / Christoph Lipps, Tobias May, Dagmar Wirth -- Cho history, cho evolution and cho genomics : an unsolvable enigma? / Florian Wurm -- Cell lines for vaccine production / Ingo Jordan, Volker Sandig -- Molecular cytogenetics characterization / Roderick A.F. MacLeod, Hans G. Drexler -- Cross-contamination and microbiological contaminations / Wilhelm G. Dirks, Cord C. Uphoff -- Cell line evolution and engineering / Hitto Kaufmann -- Gene amplification and chromosomes / Takeshi Omasa, Kyoungho Lee -- Synthetic mammalian designer cells / David Ausländer, Martin Fussenegger -- Rational approaches for transgene expression : targeted integration and episomal maintenance / Natascha Kruse, Shawal Spencer, Dagmar Wirth -- Manipulation of cell growth, metabolism and product quality attributes / Hans Henning von Horsten, Karsten Winkler, Volker Sandig -- Control of biotherapeutics glycosylation / Sandra V. Bennun, Kelley M. Heffner, Emily Blake, Andrew Chung, Michael J. Betenbaugh -- Manufacturing of complex protein products / Lore Florin, Søren K. Rasmussen, Torben P. Frandsen, Anne B. Tolstrup -- Physiology and metabolism of animal cells for production / Venkata Tayi, Michael Butler -- Functional omics for cell lines and processes / Karina Brinkrolf, Raimund Hoffrogge, Matthias Hackl, Andreas Tauch, Martina Baumann, Thomas Noll, Alexander Goesmann, Alfred Pühler, Nicole Borth -- Nutrient media for "]
[{"$nulls":4},"cell culture technology / Claudia Altamirano, Julio Berrios, Mauricio Vergara -- Bioreactors for animal cell culture / Detlef Eisenkraetzer -- High cell density cultivation processes / Natalia Ceaglio, Mariela Bollati-Fogolín, Marcos Oggero, Marina Etcheverrigaray, Ricardo B. Kratje -- Industrial cell culture process scale-up strategies and considerations / Weiwei Hu, Kelly Wiltberger -- Extraction and purification of biologics from cell culture / Nuno Fontes, Jens Vogel -- Concepts and technologies for advanced process monitoring and control / John Paul Smelko, Thomas Ryll, Dethardt Müller -- Analytical techniques and quality control of protein therapeutics / Amy Hong Que, Yang Wang, Steven Ziyi Kan -- Process characterization for upstream and downstream development / Vijay Janakiraman, Matt Westoby, Lin Conley -- Spatiotemporally controlled delivery of biopharmaceuticals / Balder Rebmann, Peter van Hoogevest, Matias Zurbriggen, Wilfried Weber."]
[null,null,null,"Sommario/riassunto","This book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell cultures. A broad spectrum of subjects relevant to biologics production and manufacturing are reviewed, including the generation of robust cell lines, a survey of functional genomics for a better understanding of cell lines and processes, as well as advances in regulatory compliant upstream and downstream development. The book is an essential reference for all those interested in translational animal cell-based pharmaceutical biotechnology."]