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[null,"1.","Record Nr.",null,"UNINA9910132205303321"]
[null,null,"Titolo",null,"Ligand design in medicinal inorganic chemistry / / edited by Tim Storr ; contributors Peter J. Barnard [and thirty seven others]"]
[null,null,"Pubbl/distr/stampa",null,"Chichester, England : , : Wiley, , 2014"]
[{"$nulls":4},"©2014"]
[null,null,"ISBN",null,"1-118-69789-8"]
[{"$nulls":4},"1-118-69719-7"]
[{"$nulls":4},"1-118-69791-X"]
[null,null,"Descrizione fisica",null,"1 online resource (493 p.)"]
[null,null,"Disciplina",null,"612/.01524"]
[null,null,"Soggetti",null,"DNA-drug interactions"]
[{"$nulls":4},"Ligand binding (Biochemistry)"]
[{"$nulls":4},"Drugs - Design"]
[{"$nulls":4},"Pharmaceutical chemistry"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references at the end of each chapters and index."]
[null,null,"Nota di contenuto",null,"Cover; Title Page; Copyright; Contents; About the Editor; List of Contributors; Chapter 1 Introduction to Ligand Design in Medicinal Inorganic Chemistry; References; Chapter 2 Platinum-Based Anticancer Agents; 2.1 Introduction; 2.2 The advent of platinum-based anticancer agents; 2.3 Strategies for overcoming the limitations of cisplatin; 2.4 The influence of ligands on the physicochemical properties of platinum anticancer complexes; 2.4.1 Lipophilicity; 2.4.2 Reactivity; 2.4.3 Rate of reduction; 2.5 Ligands for enhancing the anticancer activity of platinum complexes"]
[{"$nulls":4},"2.5.1 Ligands for improving DNA affinity2.5.2 Ligands for inhibiting enzymes; 2.6 Ligands for enhancing the tumour selectivity of platinum complexes; 2.6.1 Ligands for targeting transporters; 2.6.2 Ligands for targeting receptors; 2.6.3 Ligands for targeting the EPR effect; 2.6.4 Ligands for targeting bone cancer; 2.7 Ligands for photoactivatable platinum complexes; 2.8 Conclusions; References; Chapter 3 Coordination Chemistry and Ligand Design in the Development of Metal Based Radiopharmaceuticals; 3.1 Introduction; 3.1.1 Metals in nuclear medicine"]
[{"$nulls":4},"3.1.2 The importance of coordination chemistry3.1.3 Overview; 3.2 "]
[{"$nulls":4},"General metal based radiopharmaceutical design; 3.2.1 Choice of radionuclide; 3.2.2 Production of the radiometal starting materials; 3.2.3 Ligand and chelate design consideration; 3.3 Survey of the coordination chemistry of radiometals applicable to nuclear medicine; 3.3.1 Technetium; 3.3.2 Rhenium; 3.3.3 Gallium; 3.3.4 Indium; 3.3.5 Yttrium and lanthanides; 3.3.6 Copper; 3.3.7 Zirconium; 3.3.8 Scandium; 3.3.9 Cobalt; 3.4 Conclusions; References; Chapter 4 Ligand Design in d-Block Optical Imaging Agents and Sensors"]
[{"$nulls":4},"4.1 Summary and scope4.2 Introduction; 4.2.1 Criteria for biological imaging optical probes; 4.3 Overview of transition-metal optical probes in biomedicinal applications; 4.3.1 Common families of transition metal probes; 4.4 Ligand design for controlling photophysics; 4.4.1 Photophysical processes in transition metal optical imaging agents and sensors; 4.4.2 Photophysically active ligand families-tuning electronic levels; 4.4.3 Ligands which control photophysics through indirect effects; 4.4.4 Transition metal optical probes with carbonyl ligands; 4.5 Ligand design for controlling stability"]
[{"$nulls":4},"4.6 Ligand design for controlling transport and localisation4.6.1 Passive diffusion; 4.6.2 Active transport; 4.7 Ligand design for controlling distribution; 4.7.1 Mitochondrial-targeting probes; 4.7.2 Nuclear-targeting probes; 4.7.3 Bioconjugation; 4.8 Selected examples of ligand design for important individual probes; 4.8.1 A pH-sensitive ligand to control Ir luminescence; 4.8.2 Dimeric NHC ligands for gold cyclophanes; 4.9 Transition metal probes incorporating or capable of more than one imaging mode; 4.9.1 Bimodal MRI/optical probes; 4.9.2 Bimodal radio/optical probes"]
[{"$nulls":4},"4.9.3 Bimodal IR/optical probes"]
[null,null,null,"Sommario/riassunto","Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy.  Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated"]
[null,"2.","Record Nr.",null,"UNISA996383671703316"]
[null,null,"Autore",null,"Halley Edmond <1656-1742.>"]
[null,null,"Titolo",null,"Ephemeris ad annum a nativitate Domini 1687 [[electronic resource] ] : et ad longitudinem urbis Londinensis ex novis hypothesibus exactissime supputata et regi societati dicata"]
[null,null,"Pubbl/distr/stampa",null,"London, : Typis J. Hepinstall, impensis Guilielmi Cooper, 1687"]
[null,null,"Descrizione fisica",null,"[29] p"]
[null,null,"Soggetti",null,"Almanacs, English"]
[{"$nulls":4},"Ephemerides"]
[null,null,"Lingua di pubblicazione",null,"Latino"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Attributed to Edmond Halley.  Cf. Wing (2nd ed.)."]
[{"$nulls":4},"Filmed copy at UMI Tract Supplement reel E2 a one leaf fragment, title page only."]
[{"$nulls":4},"Reproduction of original in: British Library."]
[null,null,null,"Sommario/riassunto","eebo-0014"]