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[null,"1.","Record Nr.",null,"UNINA9910132190803321"]
[null,null,"Autore",null,"Ghosh Arun K."]
[null,null,"Titolo",null,"Structure-based design of drugs and other bioactive molecules : tools and strategies / / Arun K. Ghosh and Sandra Gemma"]
[null,null,"Pubbl/distr/stampa",null,"Weinheim, Germany : , : Wiley-VCH, , 2014"]
[{"$nulls":4},"©2014"]
[null,null,"ISBN",null,"3-527-66523-4"]
[{"$nulls":4},"3-527-66521-8"]
[{"$nulls":4},"3-527-66524-2"]
[null,null,"Descrizione fisica",null,"1 online resource (476 p.)"]
[null,null,"Disciplina",null,"615.190285"]
[null,null,"Soggetti",null,"Drug development - Data processing"]
[{"$nulls":4},"Bioactive compounds - Analysis"]
[{"$nulls":4},"Biopolymers"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Description based upon print version of record."]
[null,null,null,"Nota di bibliografia","Includes bibliographical references at the end of each chapters and index."]
[null,null,"Nota di contenuto",null,"Structure-based Design of Drugs and Other Bioactive Molecules: Tools and Strategies; Contents; Preface; 1 From Traditional Medicine to Modern Drugs: Historical Perspective of Structure-Based Drug Design; 1.1 Introduction; 1.2 Drug Discovery During 1928-1980; 1.3 The Beginning of Structure-Based Drug Design; 1.4 Conclusions; References; Part One: Concepts, Tools, Ligands, and Scaffolds for Structure-Based Design of Inhibitors; 2 Design of Inhibitors of Aspartic Acid Proteases; 2.1 Introduction; 2.2 Design of Peptidomimetic Inhibitors of Aspartic Acid Proteases"]
[{"$nulls":4},"2.3 Design of Statine-Based Inhibitors2.4 Design of Hydroxyethylene Isostere-Based Inhibitors; 2.5 Design of Inhibitors with Hydroxyethylamine Isosteres; 2.5.1 Synthesis of Optically Active α-Aminoalkyl Epoxide; 2.6 Design of (Hydroxyethyl)urea-Based Inhibitors; 2.7 (Hydroxyethyl)sulfonamide-Based Inhibitors; 2.8 Design of Heterocyclic/Nonpeptidomimetic Aspartic Acid Protease Inhibitors; 2.8.1 Hydroxycoumarin- and Hydroxypyrone-Based Inhibitors; 2.8.2 Design of Substituted Piperidine-Based Inhibitors; 2.8.3 Design of Diaminopyrimidine-Based Inhibitors"]
[{"$nulls":4},"2.8.4 Design of Acyl Guanidine-Based Inhibitors2.8.5 Design of Aminopyridine-Based Inhibitors; 2.8.6 Design of Aminoimidazole- and "]
[{"$nulls":4},"Aminohydantoin-Based Inhibitors; 2.9 Conclusions; References; 3 Design of Serine Protease Inhibitors; 3.1 Introduction; 3.2 Catalytic Mechanism of Serine Protease; 3.3 Types of Serine Protease Inhibitors; 3.4 Halomethyl Ketone-Based Inhibitors; 3.5 Diphenyl Phosphonate-Based Inhibitors; 3.6 Trifluoromethyl Ketone Based Inhibitors; 3.6.1 Synthesis of Trifluoromethyl Ketones; 3.7 Peptidyl Boronic Acid-Based Inhibitors"]
[{"$nulls":4},"3.7.1 Synthesis of α-Aminoalkyl Boronic Acid Derivatives3.8 Peptidyl α-Ketoamide- and α-Ketoheterocycle-Based Inhibitors; 3.8.1 Synthesis of α-Ketoamide and α-Ketoheterocyclic Templates; 3.9 Design of Serine Protease Inhibitors Based Upon Heterocycles; 3.9.1 Isocoumarin-Derived Irreversible Inhibitors; 3.9.2 β-Lactam-Derived Irreversible Inhibitors; 3.10 Reversible/Noncovalent Inhibitors; 3.11 Conclusions; References; 4 Design of Proteasome Inhibitors; 4.1 Introduction; 4.2 Catalytic Mechanism of 20S Proteasome; 4.3 Proteasome Inhibitors; 4.3.1 Development of Boronate Proteasome Inhibitors"]
[{"$nulls":4},"4.3.2 Development of β-Lactone Natural Product-Based Proteasome Inhibitors4.3.3 Development of Epoxy Ketone-Derived Inhibitors; 4.3.4 Noncovalent Proteasome Inhibitors; 4.4 Synthesis of β-Lactone Scaffold; 4.5 Synthesis of Epoxy Ketone Scaffold; 4.6 Conclusions; References; 5 Design of Cysteine Protease Inhibitors; 5.1 Introduction; 5.2 Development of Cysteine Protease Inhibitors with Michael Acceptors; 5.3 Design of Noncovalent Cysteine Protease Inhibitors; 5.4 Conclusions; References; 6 Design of Metalloprotease Inhibitors; 6.1 Introduction; 6.2 Design of Matrix Metalloprotease Inhibitors"]
[{"$nulls":4},"6.3 Design of Inhibitors of Tumor Necrosis Factor-α-Converting Enzymes"]
[null,null,null,"Sommario/riassunto","In contrast to previous texts focusing on either computational, structural or synthetic methods, this one-of-a-kind guide integrates all three skill sets for a complete picture of contemporary structure-based design.As a result, this practical book demonstrates how to develop a high-affinity ligand with drug-like properties for any given drug target for which a high-resolution structure exists. The authors, both of whom have successfully designed drug-like molecules that were later developed into marketed drugs, use numerous examples of recently developed drugs to present best practice in"]
[null,"2.","Record Nr.",null,"UNINA9910778368003321"]
[null,null,"Autore",null,"Arnon Harel <1972->"]
[null,null,"Titolo",null,"A theory of direct legislation [[electronic resource] /] / Harel Arnon"]
[null,null,"Pubbl/distr/stampa",null,"New York, : LFB Scholarly Pub. LLC, 2008"]
[null,null,"ISBN",null,"1-59332-305-0"]
[null,null,"Descrizione fisica",null,"1 online resource (298 p.)"]
[null,null,"Collana",null,"Law and society"]
[null,null,"Disciplina",null,"342.73/041"]
[null,null,"Soggetti",null,"Referendum - United States"]
[{"$nulls":4},"Legislation - United States"]
[{"$nulls":4},"Representative government and representation - United States"]
[{"$nulls":4},"Law - Philosophy"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references (p. 275-286) and index."]
[null,null,"Nota di contenuto",null,"Historical origins in America -- The debate over direct legislation -- Toward a legal theory of initiatives -- Qualified respect and statutory interpretation -- Qualified respect and judicial review -- Qualified respect in action -- Conclusions and future directions."]