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[null,"1.","Record Nr.",null,"UNINA9910131531503321"]
[null,null,"Autore",null,"Francoise Bex"]
[null,null,"Titolo",null,"Comparative studies between HTLV-1 and HTLV-2 function and pathobiology [[electronic resource] /] / topic editors Umberto Bertazzoni and Françoise Bex"]
[null,null,"Pubbl/distr/stampa",null,"Frontiers Media SA, 2015"]
[{"$nulls":4},"[Lausanne, Switzerland] : , : Frontiers Media SA, , 2015"]
[{"$nulls":4},"©2015"]
[null,null,"Descrizione fisica",null,"1 online resource (94 pages) : illustrations; digital, PDF file(s)"]
[null,null,"Collana",null,"Frontiers research topics"]
[null,null,"Soggetti",null,"Microbiology"]
[{"$nulls":4},"Microbiology & Immunology"]
[{"$nulls":4},"Biology"]
[{"$nulls":4},"Health & Biological Sciences"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,null,"Sommario/riassunto","Human T-cell leukemia viruses 1 and 2 (HTLV-1 and HTLV-2) have similar genomic structure but differ in pathogenicity. HTLV-1 is associated with ATL whereas HTLV-2 has not been linked to lymphoproliferative diseases. A comparative analysis between the two viruses is important to reach a better understanding of the difference in pathogenesis. A key role is attributed to the Tax proteins; Tax-1 function and structure has been thoroughly investigated but less is known about Tax-2. Recent studies on HTLV-1 and HTLV-2 expression strategies highlighted converging patterns as well as peculiar differences in the expression of regulatory proteins that might influence the pathobiology of these viruses. The study of interaction of regulatory proteins with cellular pathways factors has opened new avenues in understanding the mechanisms of gene transcription and deregulation. However, further investigation is needed on the role on innate immunity on HTLV-1 and HTLV-2 pathogenesis. Concerning the mechanisms of infection and related diseases and of their interaction with other co-infecting agents, the comparison between HTLV-1 and HTLV-2 needs further investigation."]