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[null,"1.","Record Nr.",null,"UNINA9910346668603321"]
[null,null,"Autore",null,"Gillet Daniel"]
[null,null,"Titolo",null,"Ribosome Inactivating Toxins / Daniel Gillet, Julien Barbier"]
[null,null,"Pubbl/distr/stampa",null,"MDPI - Multidisciplinary Digital Publishing Institute, 2019"]
[{"$nulls":4},"Basel, Switzerland : , : MDPI, , 2019"]
[null,null,"ISBN",null,"9783038972495"]
[{"$nulls":4},"3038972495"]
[null,null,"Descrizione fisica",null,"1 electronic resource (329 p.)"]
[null,null,"Soggetti",null,"Medicine"]
[null,null,"Lingua di pubblicazione",null,"Inglese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Sommario/riassunto","Ribosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae and bacteria. RIP activities have also been detected in animal tissues. They target a single adenine of a ribosomal RNA, thereby blocking protein synthesis and leading intoxicated cells to apoptosis. The role of plant RIPs may be related to plant defense against predators and viruses, plant senescence or bacterial pathogenesis. Most RIPs are no threat to human or animal health. However, several bacterial RIPs are major virulence factors involved in severe epidemic diseases such as dysentery or the hemolytic uremic syndrome that may occur in patients suffering from Shiga toxin-producing entero-hemorrhagic Escherichia coli infection. Several plant RIPs such as ricin toxin, abrin or sarcin have been, or may be involved in accidental or criminal poisonings, political intimidation or bio-suicides. Health crisis, biosafety and biosecurity issues became a major concern and many efforts are made to develop treatments. Finally, RIPs can be engineered into immunotoxins to destroy cancer cells or cells chronically infected by viruses.This book presents the most recent data on all aspects of RIPs including function, diversity and evolution, mechanism, pathophysiology, medical countermeasures and engineering into anticancer drugs."]
[null,"2.","Record Nr.",null,"UNINA9910131318303321"]
[null,null,"Autore",null,"Gandoulphe Pascal"]
[null,null,"Titolo",null,"Au service du roi : institutions de gouvernement et officiers dans le royaume de Valence (1556-1624"]
[null,null,"Pubbl/distr/stampa",null,"Presses universitaires de la Méditerranée, 2005"]
[{"$nulls":4},"[Place of publication not identified], : Presses universitaires de la Méditerranée, 2005"]
[null,null,"ISBN",null,"2-36781-091-5"]
[null,null,"Descrizione fisica",null,"1 online resource (340 pages)"]
[null,null,"Collana",null,"Voix des Suds"]
[null,null,"Soggetti",null,"Government - Non-U.S"]
[{"$nulls":4},"Law, Politics & Government"]
[{"$nulls":4},"Government - Europe"]
[{"$nulls":4},"Valencia (Spain : Region) Politics and government"]
[{"$nulls":4},"Valencia (Spain : Region) History"]
[{"$nulls":4},"Valencia (Spain : Region) Officials and employees"]
[null,null,"Lingua di pubblicazione",null,"Francese"]
[null,null,"Formato",null,"Materiale a stampa"]
[null,null,null,"Livello bibliografico","Monografia"]
[null,null,null,"Note generali","Bibliographic Level Mode of Issuance: Monograph"]
[null,null,null,"Nota di bibliografia","Includes bibliographical references."]
[null,null,null,"Sommario/riassunto","Cet ouvrage éclaire d’un jour nouveau la spécificité du royaume de Valence dans l’Espagne des Habsbourgs du début du règne de Philippe II aux Cortès de 1626. Après avoir brossé le panorama des institutions valenciennes, Conseil d’Aragon, Audience, vice-roi, gouverneurs, bailes généraux, maestre racional, l’auteur étudie les carrières de l’ensemble des officiers et des agents ayant exercé leurs fonctions dans cet appareil. Il rompt ainsi avec une tradition prosoprographique qui consiste à séparer les individus d’un même corps ou d’un même groupe professionnel. Cette approche novatrice permet de procéder à une analyse comparative des modalités des carrières des officiers du royaume de Valence. En outre, l’étude des liens de parenté de ces officiers royaux met en évidence les différentes modalités d’insertion dans des réseaux de solidarité qui dépassent le cadre institutionnel valencien. Cette étude, qui ouvre des voies méthodologiques nouvelles, constitue une référence indispensable pour la nouvelle historiographie du pouvoir politique dans l’Espagne d’Ancien régime."]