LEADER 00853cam2 22002531 450 001 SOBE00079590 005 20240325101448.0 100 $a20240325d1979 |||||ita|0103 ba 101 $aita 102 $aIT 200 1 $a<<2: La >>contabilita dello Stato$fSalvatore Buscema 210 $aMilano$cGiuffrè$d1979 215 $aXXIII, 1320 p.$d24 cm 461 1$1001E600200027700$12001 $aTrattato di contabilità pubblica / Salvatore Buscema 700 1$aBuscema$b, Salvatore$3AF00004427$4070$036158 801 0$aIT$bUNISOB$c20240325$gRICA 850 $aUNISOB 852 $aUNISOB$j340$m123352 912 $aSOBE00079590 940 $aM 102 Monografia moderna SBN 941 $aM 957 $a340$b005758$i-2$gSI$d123352$1rovito$2UNISOB$3UNISOB$420240325101427.0$520240325101448.0$6rovito 996 $aContabilità dello Stato$91181010 997 $aUNISOB LEADER 04185nam 22006855 450 001 9910506401703321 005 20251113211601.0 010 $a981-16-4521-3 024 7 $a10.1007/978-981-16-4521-1 035 $a(CKB)4950000000280385 035 $a(MiAaPQ)EBC6788058 035 $a(Au-PeEL)EBL6788058 035 $a(OCoLC)1280276097 035 $a(DE-He213)978-981-16-4521-1 035 $a(PPN)258302542 035 $a(EXLCZ)994950000000280385 100 $a20211020d2021 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aHereditary Breast and Ovarian Cancer $eMolecular Mechanism and Clinical Practice /$fedited by Seigo Nakamura, Daisuke Aoki, Yoshio Miki 205 $a1st ed. 2021. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2021. 215 $a1 online resource (324 pages) $cillustrations 311 08$a981-16-4520-5 327 $a1 History, Advancements, and Future Strategies -- 2 Molecular basis of BRCA1 and BRCA2 - Homologous recombination deficiency and tissue-specific carcinogenesis -- 3 Genetic Testing -- 4 Variants of uncertain significances in hereditary breast and ovarian cancer -- 5 Genetic counseling in Hereditary Breast and Ovarian Cancer -- 6 Hereditary Breast Cancer -- 7 Hereditary Ovarian Cancer -- 8 Risk-Based Breast Cancer Screening -- 9 Chemoprevention for Breast Cancer -- 10 Chemoprevention for Ovarian Cancer -- 11 Risk-Reducing Mastectomy (RRM) -- 12 Risk-reducing salpingo-oophorectomy (RRSO) -- 13 Panel Testing -- 14 Germline Findings through Precision Oncology for Ovarian Cancer -- 15 Germline Findings from Genetic Testing for Breast Cancer -- 16 Hereditary Breast and Ovarian Cancer (HBOC) Database -- 17 Ethical Issues: Overview in Genomic analysis and Clinical Context -- 18 PARP Inhibitors-Mechanism of action -- 19 PARPi - Efficacy in Hereditary Breast Cancer -- 20 Efficacy of Poly ADP-Ribose Polymerase Inhibitors for Hereditary Ovarian Cancer. 330 $aThis highly informative and clearly written book presents the basic science and the latest data on hereditary breast and ovarian cancer (HBOC) to provide an up-to-date and holistic overview of the disease. It starts off by presenting the molecular mechanisms, genetic testing and counseling, and variants of unknown significance (VUS) to help readers understand the contemporary interpretation of the disease. Further chapters focus on the surveillance, diagnosis and treatment, including chemoprevention, risk reduction and drug development based on molecular mechanisms. It also includes a chapter on the latest findings from the HBOC database, ethical issues and the parp inhibitors, and discusses innovative thinking to manage and understand the disease. Hereditary Breast and Ovarian Cancer - Molecular Mechanism and Clinical Practice offers breast surgeons, medical oncologists, gynecological oncologists and genetic counselors a comprehensive overview of the disease.Providing insights into recent scientific findings and further avenues for investigation, it is also a thought-provoking and informative read for researchers and scholars. 606 $aInternal medicine 606 $aSurgery 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aMedical genetics 606 $aInternal Medicine 606 $aSurgery 606 $aBiomedical Research 606 $aMedical Genetics 606 $aBiomedical Research 615 0$aInternal medicine. 615 0$aSurgery. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aMedical genetics. 615 14$aInternal Medicine. 615 24$aSurgery. 615 24$aBiomedical Research. 615 24$aMedical Genetics. 615 24$aBiomedical Research. 676 $a616.99449042 702 $aAoki$b Daisuke 702 $aMiki$b Yoshio 702 $aNakamura$b Seigo 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910506401703321 996 $aHereditary breast and ovarian cancer$92567415 997 $aUNINA