LEADER 01188cam1 22003131 450 001 SOBE00060177 005 20180921104110.0 100 $a20180720d1784 |||||ita|0103 ba 101 $afre 102 $aCH 200 1 $aHistoire de la littérature d'Italie, tirée de l'Italien de Mr. Tiraboschi, et abrégée par Antoine Landi ... Tome premier [-cinquieme] 210 $aBerne$d1784 215 $a5 volumi$d8° 300 $aTitolo dell'occhietto: Histoire de la littérature d'Italie 300 $aFregio xilografico sui frontespizi 463 1$1001SOBE00060178$12000 $a1 463 1$1001SOBE00060179$12000 $a2 463 1$1001SOBE00060180$12000 $a3 463 1$1001SOBE00060181$12000 $a4 463 1$1001SOBE00060183$12000 $a5 620 $dBerna$9SOBA00017885 700 1$aLandi$b, Antonio$3SOBA00017475$4070$080405 702 1$aTiraboschi, Girolamo <1731-1794>$3SOBA00017476$4730 801 0$aIT$bBEM$c20180921$gRICA 912 $aSOBE00060177 940 $aM 103 Monografia antica SBN 941 $aM 996 $aHistoire de la littérature d'Italie, tirée de l'Italien de Mr. Tiraboschi, et abrégée par Antoine Landi ... Tome premier$91727936 997 $aUNISOB LEADER 05601nam 2200733 450 001 9910132205303321 005 20200520144314.0 010 $a1-118-69789-8 010 $a1-118-69719-7 010 $a1-118-69791-X 035 $a(CKB)3710000000106462 035 $a(EBL)1683802 035 $a(SSID)ssj0001195731 035 $a(PQKBManifestationID)11703175 035 $a(PQKBTitleCode)TC0001195731 035 $a(PQKBWorkID)11161113 035 $a(PQKB)10802183 035 $a(OCoLC)867001315 035 $a(MiAaPQ)EBC1683802 035 $a(DLC) 2013051083 035 $a(Au-PeEL)EBL1683802 035 $a(CaPaEBR)ebr10867125 035 $a(CaONFJC)MIL604408 035 $a(OCoLC)879074476 035 $a(PPN)190664223 035 $a(EXLCZ)993710000000106462 100 $a20140515h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aLigand design in medicinal inorganic chemistry /$fedited by Tim Storr ; contributors Peter J. Barnard [and thirty seven others] 210 1$aChichester, England :$cWiley,$d2014. 210 4$d©2014 215 $a1 online resource (493 p.) 300 $aDescription based upon print version of record. 311 $a1-118-48852-0 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Title Page; Copyright; Contents; About the Editor; List of Contributors; Chapter 1 Introduction to Ligand Design in Medicinal Inorganic Chemistry; References; Chapter 2 Platinum-Based Anticancer Agents; 2.1 Introduction; 2.2 The advent of platinum-based anticancer agents; 2.3 Strategies for overcoming the limitations of cisplatin; 2.4 The influence of ligands on the physicochemical properties of platinum anticancer complexes; 2.4.1 Lipophilicity; 2.4.2 Reactivity; 2.4.3 Rate of reduction; 2.5 Ligands for enhancing the anticancer activity of platinum complexes 327 $a2.5.1 Ligands for improving DNA affinity2.5.2 Ligands for inhibiting enzymes; 2.6 Ligands for enhancing the tumour selectivity of platinum complexes; 2.6.1 Ligands for targeting transporters; 2.6.2 Ligands for targeting receptors; 2.6.3 Ligands for targeting the EPR effect; 2.6.4 Ligands for targeting bone cancer; 2.7 Ligands for photoactivatable platinum complexes; 2.8 Conclusions; References; Chapter 3 Coordination Chemistry and Ligand Design in the Development of Metal Based Radiopharmaceuticals; 3.1 Introduction; 3.1.1 Metals in nuclear medicine 327 $a3.1.2 The importance of coordination chemistry3.1.3 Overview; 3.2 General metal based radiopharmaceutical design; 3.2.1 Choice of radionuclide; 3.2.2 Production of the radiometal starting materials; 3.2.3 Ligand and chelate design consideration; 3.3 Survey of the coordination chemistry of radiometals applicable to nuclear medicine; 3.3.1 Technetium; 3.3.2 Rhenium; 3.3.3 Gallium; 3.3.4 Indium; 3.3.5 Yttrium and lanthanides; 3.3.6 Copper; 3.3.7 Zirconium; 3.3.8 Scandium; 3.3.9 Cobalt; 3.4 Conclusions; References; Chapter 4 Ligand Design in d-Block Optical Imaging Agents and Sensors 327 $a4.1 Summary and scope4.2 Introduction; 4.2.1 Criteria for biological imaging optical probes; 4.3 Overview of transition-metal optical probes in biomedicinal applications; 4.3.1 Common families of transition metal probes; 4.4 Ligand design for controlling photophysics; 4.4.1 Photophysical processes in transition metal optical imaging agents and sensors; 4.4.2 Photophysically active ligand families-tuning electronic levels; 4.4.3 Ligands which control photophysics through indirect effects; 4.4.4 Transition metal optical probes with carbonyl ligands; 4.5 Ligand design for controlling stability 327 $a4.6 Ligand design for controlling transport and localisation4.6.1 Passive diffusion; 4.6.2 Active transport; 4.7 Ligand design for controlling distribution; 4.7.1 Mitochondrial-targeting probes; 4.7.2 Nuclear-targeting probes; 4.7.3 Bioconjugation; 4.8 Selected examples of ligand design for important individual probes; 4.8.1 A pH-sensitive ligand to control Ir luminescence; 4.8.2 Dimeric NHC ligands for gold cyclophanes; 4.9 Transition metal probes incorporating or capable of more than one imaging mode; 4.9.1 Bimodal MRI/optical probes; 4.9.2 Bimodal radio/optical probes 327 $a4.9.3 Bimodal IR/optical probes 330 $aIncreasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated 606 $aDNA-drug interactions 606 $aLigand binding (Biochemistry) 606 $aDrugs$xDesign 606 $aPharmaceutical chemistry 615 0$aDNA-drug interactions. 615 0$aLigand binding (Biochemistry) 615 0$aDrugs$xDesign. 615 0$aPharmaceutical chemistry. 676 $a612/.01524 702 $aStorr$b Tim 702 $aBarnard$b Peter J. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910132205303321 996 $aLigand design in medicinal inorganic chemistry$92034117 997 $aUNINA LEADER 03083nam 22006735 450 001 9910794859303321 005 20230809233524.0 010 $a0-8232-7337-7 010 $a0-8232-7336-9 024 7 $a10.1515/9780823273379 035 $a(CKB)4330000000072346 035 $a(MiAaPQ)EBC4821724 035 $a(MiAaPQ)EBC4803770 035 $a(DE-B1597)555330 035 $a(DE-B1597)9780823273379 035 $a(OCoLC)965766383 035 $a(MiAaPQ)EBC4820973 035 $a(Au-PeEL)EBL4820973 035 $a(CaPaEBR)ebr11387564 035 $a(OCoLC)959274279 035 $a(EXLCZ)994330000000072346 100 $a20200723h20172017 fg 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 14$aThe Poetics of Ruins in Renaissance Literature /$fAndrew Hui 205 $aFirst edition. 210 1$aNew York, NY :$cFordham University Press,$d[2017] 210 4$d©2017 215 $a1 online resource (229 pages) $cillustrations (some color) 225 0 $aVerbal Arts: Studies in Poetics 300 $aIncludes index. 311 0 $a0-8232-7431-4 327 $tFront matter --$tContents --$tFigures and Color Plates --$tIntroduction. A Japanese Friend --$tChapter 1. The Rebirth of Poetics --$tChapter 2. The Rebirth of Ruins --$tChapter 3. Petrarch?s Vestigia and the Presence of Absence --$tChapter 4. The Hypnerotomachia Poliphili and the Erotics of Fragments --$tChapter 5. Du Bellay?s Cendre and the Formless Signifier --$tChapter 6. Spenser?s Moniment and the Allegory of Ruins --$tEpilogue. Fallen Castles and Summer Grass --$tAcknowledgments --$tNotes --$tIndex 330 $aThe Renaissance was the Ruin-naissance, the birth of the ruin as a distinct category of cultural discourse, one that inspired voluminous poetic production. For humanists, the ruin became the material sign that marked the rupture between themselves and classical antiquity. In the first full-length book to document this cultural phenomenon, Andrew Hui explains how the invention of the ruin propelled poets into creating works that were self-aware of their absorption of the past as well as their own survival in the future. 410 0$aVerbal arts--studies in poetics. 606 $aRuins in literature 606 $aEuropean literature$yRenaissance, 1450-1600$xHistory and criticism 610 $aAesthetic of Ruins. 610 $aCultural Philology. 610 $aDu Bellay. 610 $aHypnerotomachia Poliphili. 610 $aMonuments. 610 $aPetrarch. 610 $aPoetic Immortality. 610 $aRenaissance Aesthetics. 610 $aSpenser. 615 0$aRuins in literature. 615 0$aEuropean literature$xHistory and criticism. 676 $a809.02 700 $aHui$b Andrew$4aut$4http://id.loc.gov/vocabulary/relators/aut$01580012 801 0$bDE-B1597 801 1$bDE-B1597 906 $aBOOK 912 $a9910794859303321 996 $aThe Poetics of Ruins in Renaissance Literature$93860556 997 $aUNINA