LEADER 01022cam0 22003013 450 001 SOB003382 005 20220530075956.0 010 $a8887293473 100 $a20040211d2000 |||||ita|0103 ba 101 $aita 102 $aIT 200 1 $aLezioni di diritto comunitario$fLuigi Ferrari Bravo$gEnzo Moavero Milanesi 205 $a3. ed 210 $aNapoli$cEditoriale scientifica$d2000 215 $aXII, 607 p.$d24 cm 225 2 $aManuali per l'università 410 1$1001LAEC00015927$12001 $a*Manuali per l'università 700 1$aFerrari Bravo$b, Luigi$3AF00004965$4070$0135051 702 1$aMoavero Milanesi, Enzo$3AF00006607$4070 801 0$aIT$bUNISOB$c20220530$gRICA 850 $aUNISOB 852 $aUNISOB$j340$m102387 912 $aSOB003382 940 $aM 102 Monografia moderna SBN 941 $aM 957 $a340$b000719$gSI$d102387$rACQUISTO$p75.000$1rovito$2UNISOB$3UNISOB$420220530075937.0$520220530075956.0$6rovito 996 $aLezioni di diritto comunitario$91586378 997 $aUNISOB LEADER 03958nam 22006255 450 001 9910298332803321 005 20200705153832.0 010 $a3-7091-1806-9 024 7 $a10.1007/978-3-7091-1806-1 035 $a(CKB)3710000000248978 035 $a(EBL)1966152 035 $a(OCoLC)908084961 035 $a(SSID)ssj0001353663 035 $a(PQKBManifestationID)11768648 035 $a(PQKBTitleCode)TC0001353663 035 $a(PQKBWorkID)11316872 035 $a(PQKB)10768430 035 $a(MiAaPQ)EBC1966152 035 $a(DE-He213)978-3-7091-1806-1 035 $a(PPN)181347687 035 $a(EXLCZ)993710000000248978 100 $a20140922d2014 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aRas Superfamily Small G Proteins: Biology and Mechanisms 1 $eGeneral Features, Signaling /$fedited by Alfred Wittinghofer 205 $a1st ed. 2014. 210 1$aVienna :$cSpringer Vienna :$cImprint: Springer,$d2014. 215 $a1 online resource (447 p.) 300 $aDescription based upon print version of record. 311 $a3-7091-1805-0 320 $aIncludes bibliographical references and index at the end of each chapters. 327 $aEvolution of the Ras Superfamily of GTPases -- The structure of the G domain of the Ras superfamily -- GEFs and GAPs: Mechanisms and Structures -- Bacterial protein toxins acting on small GTPases -- Posttranslational modifications of small G proteins -- Targeting the Raf-MEK-ERK Mitogen-Activates Protein Kinase Cascade for the Treatment of RAS Mutant Cancers -- RAS Genes and Cancer -- The Spatial Organization of Ras Signaling -- Ras Nanoclusters -- Mouse Models of Ras induced Tumors and Developmental Disorders -- Rap signaling -- The coordinated biology and signaling partners of Ral G-proteins -- Structure and Function of the mTOR Activator Rheb -- Classical Rho proteins: Biochemistry of molecular switch function and regulation -- Atypical Rho family members -- Molecular Structures, Cellular Functions and Physiological Roles of Rho Effectors -- Principles driving the spatial organization of Rho GTPase signaling at synapses -- Rho GTPases in Cancer. 330 $aThis first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field. 606 $aCytology 606 $aProteins 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050 615 0$aCytology. 615 0$aProteins. 615 14$aCell Biology. 615 24$aProtein Science. 615 24$aProtein Structure. 676 $a570 676 $a571.6 676 $a572.6 676 $a572633 702 $aWittinghofer$b Alfred$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298332803321 996 $aRas Superfamily Small G Proteins: Biology and Mechanisms 1$92513120 997 $aUNINA