LEADER 00938nam0-22002651i-450- 001 990000137360403321 035 $a000013736 035 $aFED01000013736 035 $a(Aleph)000013736FED01 035 $a000013736 100 $a20011111d--------km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $a<>stato degli argini del Po fra Secchia e Panaro nella provincia di Mantova$econsiderazioni e proposte dedicate agliabitanti dei distretti di Revere e Sermide$fAlessandro Ferretti. 210 $aMantova$cPremiato stabilimento tipografico Mondovi$d1879 215 $a35 p.$cill.$d25 cm 700 1$aFerretti,$bAlessandro$04750 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990000137360403321 952 $a13 MISC 414 05$b8831$fFINBC 959 $aFINBC 996 $aStato degli argini del Po fra Secchia e Panaro nella provincia di Mantova$9113458 997 $aUNINA DB $aING01 LEADER 01673nam 2200385 n 450 001 996392254703316 005 20200824121844.0 035 $a(CKB)4940000000108960 035 $a(EEBO)2240902304 035 $a(UnM)99864287e 035 $a(UnM)99864287 035 $a(EXLCZ)994940000000108960 100 $a19931021d1657 uy | 101 0 $aeng 135 $aurbn||||a|bb| 200 12$aA testimony of the true Light of the world·$b[electronic resource] $eWhich is given to every man that comes into the world, and of the true measure of the gift of God, given to every one to profit withal. And a true witness, and faithful: ... /$fGiven forth for the good of all people, in pity to all souls, by him who is not known to the world, but a stranger in it, Geo. Fox 210 $aLondon $cPrinted for Giles Calvert, and sold in his shop at the black Spread-Eagle, at the west end of Pauls$d1657 215 $a50, [2] p 300 $aPreface signed: E.B., i.e. Edward Burrough. 300 $aThe last leaf is blank. 300 $aAnnotation on Thomason copy: "Jan: 24. 1656"; the 7 in the imprint date has been crossed out. 300 $aReproduction of the original in the British Library. 330 $aeebo-0018 606 $aSociety of Friends$xDoctrines$vEarly works to 1800 615 0$aSociety of Friends$xDoctrines 700 $aFox$b George$f1624-1691.$0793686 701 $aBurrough$b Edward$f1634-1662.$01001305 801 0$bCu-RivES 801 1$bCu-RivES 801 2$bCStRLIN 801 2$bWaOLN 906 $aBOOK 912 $a996392254703316 996 $aA testimony of the true Light of the world·$92417230 997 $aUNISA LEADER 00958cam0 2200265 450 001 E600200011484 005 20240222083901.0 010 $a883484663X 100 $a20050715d2005 |||||ita|0103 ba 101 $aita 102 $aIT 200 1 $aConsumatori e processo$ela tutela degli interessi collettivi dei consumatori$eatti de Convegno tenutosi a Torino il 28-29 maggio 2004$fa cura di Sergio Chiarloni e Paolo Fiorio 210 $aTorino$cGiappichelli$d2005 215 $aXIV, 255 p.$d24 cm 702 1$aChiarloni, Sergio$3AF00019891$4070 702 1$aFiorio, Paolo$3A600200031645$4070 801 0$aIT$bUNISOB$c20240222$gRICA 850 $aUNISOB 852 $aUNISOB$j340$m126502 912 $aE600200011484 940 $aM 102 Monografia moderna SBN 941 $aM 957 $a340$b005045$gSi$d126502$racquisto$1pomicino$2UNISOB$3UNISOB$420050715074150.0$520240222083901.0$6rovito 996 $aConsumatori e processo$91055694 997 $aUNISOB LEADER 10469oam 22005293 450 001 9910974791203321 005 20251116135220.0 010 $a9780470512135$b(electronic bk.) 010 $z9780470033104 035 $a(MiAaPQ)EBC326409 035 $a(Au-PeEL)EBL326409 035 $a(CaPaEBR)ebr10297481 035 $a(CaONFJC)MIL113527 035 $a(OCoLC)183426187 035 $a(MiAaPQ)EBC7103328 035 $a(CKB)17691342000041 035 $a(EXLCZ)9917691342000041 100 $a20220831d2007 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMass Spectrometry $ePrinciples and Applications 205 $a3rd ed. 210 1$aNewy York :$cJohn Wiley & Sons, Incorporated,$d2007. 210 4$dİ2013. 215 $a1 online resource (503 pages) 311 08$aPrint version: de Hoffmann, Edmond Mass Spectrometry Newy York : John Wiley & Sons, Incorporated,c2007 9780470033104 327 $aIntro -- Mass Spectrometry -- Contents -- Preface -- Introduction -- Principles -- Diagram of a Mass Spectrometer -- History -- Ion Free Path -- 1 Ion Sources -- 1.1 Electron Ionization -- 1.2 Chemical Ionization -- 1.2.1 Proton Transfer -- 1.2.2 Adduct Formation -- 1.2.3 Charge-Transfer Chemical Ionization -- 1.2.4 Reagent Gas -- 1.2.5 Negative Ion Formation -- 1.2.6 Desorption Chemical Ionization -- 1.3 Field Ionization -- 1.4 Fast Atom Bombardment and Liquid Secondary Ion Mass Spectrometry -- 1.5 Field Desorption -- 1.6 Plasma Desorption -- 1.7 Laser Desorption -- 1.8 Matrix-Assisted Laser Desorption Ionization -- 1.8.1 Principle of MALDI -- 1.8.2 Practical Considerations -- 1.8.3 Fragmentations -- 1.8.4 Atmospheric Pressure Matrix-Assisted Laser Desorption Ionization -- 1.9 Thermospray -- 1.10 Atmospheric Pressure Ionization -- 1.11 Electrospray -- 1.11.1 Multiply Charged Ions -- 1.11.2 Electrochemistry and Electric Field as Origins of Multiply Charged Ions -- 1.11.3 Sensitivity to Concentration -- 1.11.4 Limitation of Ion Current from the Source by the Electrochemical Process -- 1.11.5 Practical Considerations -- 1.12 Atmospheric Pressure Chemical Ionization -- 1.13 Atmospheric Pressure Photoionization -- 1.14 Atmospheric Pressure Secondary Ion Mass Spectrometry -- 1.14.1 Desorption Electrospray Ionization -- 1.14.2 Direct Analysis in Real Time -- 1.15 Inorganic Ionization Sources -- 1.15.1 Thermal Ionization Source -- 1.15.2 Spark Source -- 1.15.3 Glow Discharge Source -- 1.15.4 Inductively Coupled Plasma Source -- 1.15.5 Practical Considerations -- 1.16 Gas-Phase Ion-Molecule Reactions -- 1.17 Formation and Fragmentation of Ions: Basic Rules -- 1.17.1 Electron Ionization and Photoionization Under Vacuum -- 1.17.2 Ionization at Low Pressure or at Atmospheric Pressure -- 1.17.3 Proton Transfer -- 1.17.4 Adduct Formation. 327 $a1.17.5 Formation of Aggregates or Clusters -- 1.17.6 Reactions at the Interface between Source and Analyser -- 2 Mass Analysers -- 2.1 Quadrupole Analysers -- 2.1.1 Description -- 2.1.2 Equations of Motion -- 2.1.3 Ion Guide and Collision Cell -- 2.1.4 Spectrometers with Several Quadrupoles in Tandem -- 2.2 Ion Trap Analysers -- 2.2.1 The 3D Ion Trap -- 2.2.2 The 2D Ion Trap -- 2.3 The Electrostatic Trap or 'Orbitrap' -- 2.4 Time-of-Flight Analysers -- 2.4.1 Linear Time-of-Flight Mass Spectrometer -- 2.4.2 Delayed Pulsed Extraction -- 2.4.3 Reflectrons -- 2.4.4 Tandem Mass Spectrometry with Time-of-Flight Analyser -- 2.4.5 Orthogonal Acceleration Time-of-Flight Instruments -- 2.5 Magnetic and Electromagnetic Analysers -- 2.5.1 Action of the Magnetic Field -- 2.5.2 Electrostatic Field -- 2.5.3 Dispersion and Resolution -- 2.5.4 Practical Considerations -- 2.5.5 Tandem Mass Spectrometry in Electromagnetic Analysers -- 2.6 Ion Cyclotron Resonance and Fourier Transform Mass Spectrometry -- 2.6.1 General Principle -- 2.6.2 Ion Cyclotron Resonance -- 2.6.3 Fourier Transform Mass Spectrometry -- 2.6.4 MS n in ICR/FTMS Instruments -- 2.7 Hybrid Instruments -- 2.7.1 Electromagnetic Analysers Coupled to Quadrupoles or Ion Trap -- 2.7.2 Ion Trap Analyser Combined with Time-of-Flight or Ion Cyclotron Resonance -- 2.7.3 Hybrids Including Time-of-Flight with Orthogonal Acceleration -- 3 Detectors and Computers -- 3.1 Detectors -- 3.1.1 Photographic Plate -- 3.1.2 Faraday Cup -- 3.1.3 Electron Multipliers -- 3.1.4 Electro-Optical Ion Detectors -- 3.2 Computers -- 3.2.1 Functions -- 3.2.2 Instrumentation -- 3.2.3 Data Acquisition -- 3.2.4 Data Conversion -- 3.2.5 Data Reduction -- 3.2.6 Library Search -- 4 Tandem Mass Spectrometry -- 4.1 Tandem Mass Spectrometry in Space or in Time -- 4.2 Tandem Mass Spectrometry Scan Modes. 327 $a4.3 Collision-Activated Decomposition or Collision-Induced Dissociation -- 4.3.1 Collision Energy Conversion to Internal Energy -- 4.3.2 High-Energy Collision (keV) -- 4.3.3 Low-Energy Collision (between 1 and 100 eV) -- 4.4 Other Methods of Ion Activation -- 4.5 Reactions Studied in MS/MS -- 4.6 Tandem Mass Spectrometry Applications -- 4.6.1 Structure Elucidation -- 4.6.2 Selective Detection of Target Compound Class -- 4.6.3 Ion-Molecule Reaction -- 4.6.4 The Kinetic Method -- 5 Mass Spectrometry/Chromatography Coupling -- 5.1 Elution Chromatography Coupling Techniques -- 5.1.1 Gas Chromatography/mass Spectrometry -- 5.1.2 Liquid Chromatography/mass Spectrometry -- 5.1.3 Capillary Electrophoresis/mass Spectrometry -- 5.2 Chromatography Data Acquisition Modes -- 5.3 Data Recording and Treatment -- 5.3.1 Data Recording -- 5.3.2 Instrument Control and Treatment of Results -- 6 Analytical Information -- 6.1 Mass Spectrometry Spectral Collections -- 6.2 High Resolution -- 6.2.1 Information at Different Resolving Powers -- 6.2.2 Determination of the Elemental Composition -- 6.3 Isotopic Abundances -- 6.4 Low-Mass Fragments and Lost Neutrals -- 6.5 Number of Rings or Unsaturations -- 6.6 Mass and Electron Parities, Closed-Shell Ions and Open-Shell Ions -- 6.6.1 Electron Parity -- 6.6.2 Mass Parity -- 6.6.3 Relationship between Mass and Electron Parity -- 6.7 Quantitative Data -- 6.7.1 Specificity -- 6.7.2 Sensitivity and Detection Limit -- 6.7.3 External Standard Method -- 6.7.4 Sources of Error -- 6.7.5 Internal Standard Method -- 6.7.6 Isotopic Dilution Method -- 7 Fragmentation Reactions -- 7.1 Electron Ionization and Fragmentation Rates -- 7.2 Quasi-Equilibrium and RRKM Theory -- 7.3 Ionization and Appearance Energies -- 7.4 Fragmentation Reactions of Positive Ions -- 7.4.1 Fragmentation of Odd-Electron Cations or Radical Cations. 327 $a7.4.2 Fragmentation of Cations with an Even Number of Electrons (EE ) -- 7.4.3 Fragmentations Obeying the Parity Rule -- 7.4.4 Fragmentations not Obeying the Parity Rule -- 7.5 Fragmentation Reactions of Negative Ions -- 7.5.1 Fragmentation Mechanisms of Even Electron Anions (EE - ) -- 7.5.2 Fragmentation Mechanisms of Radical Anions -- 7.6 Charge Remote Fragmentation -- 7.7 Spectrum Interpretation -- 7.7.1 Typical Ions -- 7.7.2 Presence of the Molecular Ion -- 7.7.3 Typical Neutrals -- 7.7.4 A Few Examples of the Interpretation of Mass Spectra -- 8 Analysis of Biomolecules -- 8.1 Biomolecules and Mass Spectrometry -- 8.2 Proteins and Peptides -- 8.2.1 ESI and MALDI -- 8.2.2 Structure and Sequence Determination Using Fragmentation -- 8.2.3 Applications -- 8.3 Oligonucleotides -- 8.3.1 Mass Spectra of Oligonucleotides -- 8.3.2 Applications of Mass Spectrometry to Oligonucleotides -- 8.3.3 Fragmentation of Oligonucleotides -- 8.3.4 Characterization of Modified Oligonucleotides -- 8.4 Oligosaccharides -- 8.4.1 Mass Spectra of Oligosaccharides -- 8.4.2 Fragmentation of Oligosaccharides -- 8.4.3 Degradation of Oligosaccharides Coupled with Mass Spectrometry -- 8.5 Lipids -- 8.5.1 Fatty Acids -- 8.5.2 Acylglycerols -- 8.5.3 Bile Acids -- 8.6 Metabolomics -- 8.6.1 Mass Spectrometry in Metabolomics -- 8.6.2 Applications -- 9 Exercises -- Questions -- Answers -- Appendices -- 1 Nomenclature -- 1.1 Units -- 1.2 Definitions -- 1.3 Analysers -- 1.4 Detection -- 1.5 Ionization -- 1.6 Ion Types -- 1.7 Ion-Molecule Reaction -- 1.8 Fragmentation -- 2 Acronyms and Abbreviations -- 3 Fundamental Physical Constants -- 4A Table of Isotopes in Ascending Mass Order -- 4B Table of Isotopes in Alphabetical Order -- 5 Isotopic Abundances (in %) for Various Elemental Compositions CHON -- 6 Gas-Phase Ion Thermochemical Data of Molecules. 327 $a7 Gas-Phase Ion Thermochemical Data of Radicals -- 8 Literature on Mass Spectrometry -- 9 Mass Spectrometry on Internet -- Index. 330 $aThe latest edition of a highly successful textbook, Mass Spectrometry, Third Edition provides students with a complete overview of the principles, theories and key applications of modern mass spectrometry. All instrumental aspects of mass spectrometry are clearly and concisely described: sources, analysers and detectors. Tandem mass spectrometry is introduced early on and then developed in more detail in a later chapter. Emphasis is placed throughout the text on optimal utilisation conditions. Various fragmentation patterns are described together with analytical information that derives from the mass spectra. This new edition has been thoroughly revised and updated and has been redesigned to give the book a more contemporary look. As with previous editions it contains numerous examples, references and a series of exercises of increasing difficulty to encourage student understanding. Updates include: Increased coverage of MALDI and ESI, more detailed description of time of flight spectrometers, new material on isotope ratio mass spectrometry, and an expanded range of applications. Mass Spectrometry, Third Edition is an invaluable resource for all undergraduate and postgraduate students using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture, material science and food science. It is also of interest for researchers looking for an overview of the latest techniques and developments. 606 $aMass spectrometry 615 0$aMass spectrometry. 676 $a543/.0873 700 $aHoffmann$b Edmond de$0287084 701 $aStroobant$b Vincent$067142 701 $aHoffmann$b Edmond de$0287084 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 912 $a9910974791203321 996 $aMass spectrometry$9377157 997 $aUNINA