LEADER 02120nam 2200409z- 450 001 9910346750303321 005 20210212 035 $a(CKB)4920000000094211 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/59417 035 $a(oapen)doab59417 035 $a(EXLCZ)994920000000094211 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aSingle-Domain Antibodies: Biology, Engineering and Emerging Applications 210 $cFrontiers Media SA$d2018 215 $a1 online resource (338 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-432-0 330 $aSingle-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics. 517 $aSingle-Domain Antibodies 606 $aMedicine and Nursing$2bicssc 610 $aantibody discovery 610 $aantibody engineering 610 $adiagnostic antibody 610 $asingle-domain antibody 610 $atherapeutic antibody 615 7$aMedicine and Nursing 700 $aKevin A. Henry$4auth$01279436 702 $aC. Roger MacKenzie$4auth 906 $aBOOK 912 $a9910346750303321 996 $aSingle-Domain Antibodies: Biology, Engineering and Emerging Applications$93015375 997 $aUNINA LEADER 01134nam0 22003013i 450 001 UFI0102920 005 20251003044427.0 010 $a0201523973 100 $a20101227d1990 ||||0itac50 ba 101 | $aeng 102 $aus 181 1$6z01$ai $bxxxe 182 1$6z01$an 200 1 $aInside the EISA computers$fTony Dowden 210 $aReading$cAddison Wesley Publishing Company$d1990 215 $aXVIII, 236 p.$d24 cm. 606 $aMicroelaboratori elettronici$2FIR$3CFIC003267$9I 676 $a621.39$9INGEGNERIA DEGLI ELABORATORI$v14 676 $a621.3916$9INGEGNERIA DEGLI ELEBORATORI. OPERE GENERALI SU SPECIFICI TIPI DI ELABORATORE. MICROELABORATORI$v22 700 1$aDowden$b, Tony$3UFIV081854$4070$0772073 801 3$aIT$bIT-000000$c20101227 850 $aIT-BN0095 901 $bNAP 01$cSALA DING $n$ 912 $aUFI0102920 950 0$aBiblioteca Centralizzata di Ateneo$b1 v.$c1 v.$d 01SALA DING 621.39 DOW.in$e 0102 0000004765 VMA A4 1 v.$fY $h19931020$i20101227 977 $a 01 996 $aInside the EISA computers$91575971 997 $aUNISANNIO