LEADER 03205nam 2200469z- 450 001 9910136797203321 005 20210211 035 $a(CKB)3710000000631150 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54469 035 $a(oapen)doab54469 035 $a(EXLCZ)993710000000631150 100 $a20202102d2016 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNeural Circuitry of Behavioral Flexibility: Dopamine and Related Systems 210 $cFrontiers Media SA$d2016 215 $a1 online resource (165 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-795-6 330 $aDecades of research have identified a role for dopamine neurotransmission in prefrontal cortical function and flexible cognition. Abnormal dopamine neurotransmission underlies many cases of cognitive dysfunction. New techniques using optogenetics have allowed for ever more precise functional segregation of areas within the prefrontal cortex, which underlie separate cognitive functions. Learning theory predictions have provided a very useful framework for interpreting the neural activity of dopamine neurons, yet even dopamine neurons present a range of responses, from salience to prediction error signaling. The functions of areas like the Lateral Habenula have been recently described, and its role, presumed to be substantial, is largely unknown. Many other neural systems interact with the dopamine system, like cortical GABAergic interneurons, making it critical to understand those systems and their interactions with dopamine in order to fully appreciate dopamine's role in flexible behavior. Advances in human clinical research, like exome sequencing, are driving experimental hypotheses which will lead to fruitful new research directions, but how do (or should?) these clinical findings inform basic research? Following new information from these techniques, we may begin to develop a fresh understanding of human disease states which will inform novel treatment possibilities. However, we need an operational framework with which to interpret these new findings. Therefore, the purpose of this Research Topic is to integrate what we know of dopamine, the prefrontal cortex and flexible behavior into a clear framework, which will illuminate clear, testable directions for future research. 517 $aNeural Circuitry of Behavioral Flexibility 606 $aNeurosciences$2bicssc 610 $aanterior cingulate cortex (ACC) 610 $aAttentional set-shifting 610 $abasal forebrain 610 $abehavioral flexibility 610 $aDopamine 610 $aendocannabinoid system 610 $alateral habenula (LHb) 610 $aLocus coeruleus (LC) 610 $amedial prefrontal cortex (mPFC) 610 $amotivational salience 615 7$aNeurosciences 700 $aMatthew R. Roesch$4auth$01326343 702 $aGregory B. Bissonette$4auth 906 $aBOOK 912 $a9910136797203321 996 $aNeural Circuitry of Behavioral Flexibility: Dopamine and Related Systems$93037356 997 $aUNINA LEADER 01442nam0 22003733i 450 001 UFI0091473 005 20251003044427.0 010 $a047151778X 010 $a0471600903 100 $a20100521d1990 ||||0itac50 ba 101 | $aeng 102 $aus 181 1$6z01$ai $bxxxe 182 1$6z01$an 200 1 $aProbability and statistics in engineering and management science$fWilliam W. Hines, Douglas C. Montgomery 205 $a3. ed 210 $aNew York [etc.]$cWiley$d1990 215 $aXIX, 732 p.$d23 cm. 606 $aProbabilità$2FIR$3CFIC002417$9E 606 $aStatistica$2FIR$3CFIC000038$9E 676 $a519.2$9Probabilità$v14 676 $a519.2$9PROBABILITA' E MATEMATICA APPLICATA. PROBABILITA'$v22 696 $aScienze statistiche 699 $aStatistica$yScienze statistiche 700 1$aHines$b, William W.$3UBOV096038$4070$0108084 701 1$aMontgomery$b, Douglas C.$3MILV020195$4070$09293 801 3$aIT$bIT-000000$c20100521 850 $aIT-BN0095 901 $bNAP 01$cRCOST $nMateriale bibliografico trasferito come da verbale del 15/07/2009 912 $aUFI0091473 950 0$aBiblioteca Centralizzata di Ateneo$b1 v.$d 01RCOST 519.2 HIN.pr$e 0102 0000076455 VMA 1 v.$fY $h20091210$i20091210 977 $a 01 996 $aProbability and statistics in engineering and management science$9103149 997 $aUNISANNIO