LEADER 01004nam0-22002891i-450- 001 990000612490403321 005 20001010 035 $a000061249 035 $aFED01000061249 035 $a(Aleph)000061249FED01 035 $a000061249 100 $a20001010d--------km-y0itay50------ba 101 0 $aita 105 $ay-------001yy 200 1 $aRAPPRESENTAZIONE PROBABILISTICA DEI MOTI SISMICI E DEI LORO EFFETTI SUGLI EDIFICI,1966$fGRANDORI G. 210 $aMilano$cI.S.T.C.$d1966 300 $aAtti dell'Istituto di Scienza e tecnica delle Costruzioni del politecnico di Milano. 610 0 $aAtti ed estratti di Università ed Istituti Universitari Italiani. 700 1$aGrandori,$bGiuseppe$f<1921-2011>$0424729 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990000612490403321 952 $a07 U/536$b$fDINSC 959 $aDINSC 996 $aRAPPRESENTAZIONE PROBABILISTICA DEI MOTI SISMICI E DEI LORO EFFETTI SUGLI EDIFICI,1966$9317098 997 $aUNINA DB $aING01 LEADER 05461nam 2200733Ia 450 001 9910139918503321 005 20250620182501.0 010 $a9786612189050 010 $a9781282189058 010 $a1282189050 010 $a9781444313833 010 $a1444313835 010 $a9781444313826 010 $a1444313827 035 $a(CKB)1000000000794259 035 $a(EBL)454404 035 $a(OCoLC)609844402 035 $a(SSID)ssj0000354243 035 $a(PQKBManifestationID)11251807 035 $a(PQKBTitleCode)TC0000354243 035 $a(PQKBWorkID)10302579 035 $a(PQKB)10302913 035 $a(MiAaPQ)EBC454404 035 $a(Au-PeEL)EBL454404 035 $a(CaPaEBR)ebr10310593 035 $a(CaONFJC)MIL218905 035 $a(Perlego)2760847 035 $a(EXLCZ)991000000000794259 100 $a19940217d1994 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aGenetic analysis $eprinciples, scope, and objectives /$fJohn R.S. Fincham 205 $a1st ed. 210 $aOxford ;$aBoston $cBlackwell Scientific Publications$d1994 215 $a1 online resource (241 p.) 300 $aDescription based upon print version of record. 311 08$a9780632036592 311 08$a0632036591 320 $aIncludes bibliographical references and index. 327 $aGENETIC ANALYSIS; CONTENTS; PREFACE; INTRODUCTION: THE EXPANDING SCOPE OF GENETICS; 1: DISSECTING THE GENOME USING NATURAL GENETIC SYSTEMS; The eukaryotic system; Eukaryotes distinguished from prokaryotes; Mitosis and chromosome structure; Alternation of haploid and diploid phases in the sexual cycle; Meiosis and the rules of classical genetics; Meiosis; Single-factor genetic ratios and their explanation; Independent assortment of different allele-pairs; Testing data for fit to theoretical ratios; Linkage groups and the nature of crossovers; Map units and map distance 327 $aPlacing Linked genes in sequenceDistinguishing between independent assorment and distant linkage; Mapping centromeres using tetrads; Sex linkage; Segregation and linkage in human genetics; Assigning linkage groups to chromosomes; Genetic analysis of bacteria and bacteriophage; Three modes of gene transfer in bacteria; Time-of-entry mapping in E. coli; Analogy with sexual recombination and segregation; Stable partial diploids - F' plasmids; Bacteriophage lambda - a virus in the chromosome; Bacteriophage T4 - a model recombinational system; Eukaryotic organelle genetics 327 $aExceptions to the rule of equal results from reciprocal crossesChloroplast variants; Mitochondrial variants; Summary and perspective; Further reading; References; 2: FROM MUTATIONS TO GENES; Defining the gene by mutation and complementation; What is it that the markers mark?; The collection of mutants; Sorting of mutants into complementation groups; An interim definition of the gene; Mapping within the gene; The detection of recombination within genes; Mapping by reference to flanking markers; Recombination frequency; Deletion mapping; The determination by genes of protein structure 327 $aColinearity of the gene and its encoded protein productBiochemistry of polypeptide synthesis; Not all genes encode proteins; Conclusions; References; 3: THE GENE AS DNA SEQUENCE; Characterization of DNA fragments; Restriction endonucleases; Separating aod sizing DNA fragments; Probing for specific sequences; Making restriction-site maps; Cloning and cloning vectors; Making recombinant DNA molecules; Escherichia coli plasmid vectors; Yeast 2-um plasmid and shuttle vectors; Lambda (l) bacteriophage and cosmid vectors; Yeast artificial chromosomes (YACs) 327 $aScreening DNA libraries for functional genesGenomic libraries and cDNA libraries; Gene identification by complementation of mutants; Screening gene libraries with DNA probes; Designing gene-specific probes; Use of cDNA probes; Screening for gene expression; Probing across species or group boundaries; Positional cloning; Confirming the identity of cloned sequences; DNA sequence and open reading frames; Using the clone to disrupt the corresponding gene; Hybridization back to chromosomes; Simultaneous mutagenesis and gene tagging; The principle; Transposon tags; Conclusion; References 327 $a4: THE EVOLVING CONCEPT OF THE GENE 330 $aAuthored by a very eminent geneticist, this text gives students a thorough appreciation of the development and potential of analytical genetic techniques. 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